Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Magnusdottir, Bergrun Tinna
MetadataShow full item record
CitationPLoS. ONE. 2010, 5(11):e13957
AbstractBACKGROUND: Coronary heart disease (CHD) mortality rates have been decreasing in Iceland since the 1980s. We examined how much of the decrease between 1981 and 2006 could be attributed to medical and surgical treatments and how much to changes in cardiovascular risk factors. METHODOLOGY: The previously validated IMPACT CHD mortality model was applied to the Icelandic population. The data sources were official statistics, national quality registers, published trials and meta-analyses, clinical audits and a series of national population surveys. PRINCIPAL FINDINGS: Between 1981 and 2006, CHD mortality rates in Iceland decreased by 80% in men and women aged 25 to 74 years, which resulted in 295 fewer deaths in 2006 than if the 1981 rates had persisted. Incidence of myocardial infarction (MI) decreased by 66% and resulted in some 500 fewer incident MI cases per year, which is a major determinant of possible deaths from MI. Based on the IMPACT model approximately 73% (lower and upper bound estimates: 54%-93%) of the mortality decrease was attributable to risk factor reductions: cholesterol 32%; smoking 22%; systolic blood pressure 22%, and physical inactivity 5% with adverse trends for diabetes (-5%), and obesity (-4%). Approximately 25% (lower and upper bound estimates: 8%-40%) of the mortality decrease was attributable to treatments in individuals: secondary prevention 8%; heart failure treatments 6%; acute coronary syndrome treatments 5%; revascularisation 3%; hypertension treatments 2%, and statins 0.5%. CONCLUSIONS: Almost three quarters of the large CHD mortality decrease in Iceland between 1981 and 2006 was attributable to reductions in major cardiovascular risk factors in the population. These findings emphasize the value of a comprehensive prevention strategy that promotes tobacco control and a healthier diet to reduce incidence of MI and highlights the potential importance of effective, evidence based medical treatments.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to PloS one
- Explaining the decline in coronary heart disease mortality rates in the Slovak Republic between 1993-2008.
- Authors: Psota M, Bandosz P, Gonçalvesová E, Avdičová M, Bucek Pšenková M, Studenčan M, Pekarčíková J, Capewell S, O'Flaherty M
- Issue date: 2018
- Explaining the decline in coronary heart disease mortality in Turkey between 1995 and 2008.
- Authors: Unal B, Sözmen K, Arık H, Gerçeklioğlu G, Altun DU, Şimşek H, Doganay S, Demiral Y, Aslan Ö, Bennett K, O'Flaherty M, Capewell S, Critchley J
- Issue date: 2013 Dec 5
- Modelling coronary heart disease mortality in Northern Ireland between 1987 and 2007: broader lessons for prevention.
- Authors: Hughes J, Kee F, O'Flaherty M, Critchley J, Cupples M, Capewell S, Bennett K
- Issue date: 2013 Apr
- Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002.
- Authors: Björck L, Rosengren A, Bennett K, Lappas G, Capewell S
- Issue date: 2009 May
- Explaining the decline in coronary heart disease mortality in England and Wales between 1981 and 2000.
- Authors: Unal B, Critchley JA, Capewell S
- Issue date: 2004 Mar 9