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dc.contributor.authorAndersen, Mette K
dc.contributor.authorAutio, Kirsi
dc.contributor.authorBarbany, Gisela
dc.contributor.authorBorgström, Georg
dc.contributor.authorCavelier, Lucia
dc.contributor.authorGolovleva, Irina
dc.contributor.authorHeim, Sverre
dc.contributor.authorHeinonen, Kristina
dc.contributor.authorHovland, Randi
dc.contributor.authorJohannsson, Johann H
dc.contributor.authorJohansson, Bertil
dc.contributor.authorKjeldsen, Eigil
dc.contributor.authorNordgren, Ann
dc.contributor.authorPalmqvist, Lars
dc.contributor.authorForestier, Erik
dc.date.accessioned2012-05-11T09:39:18Z
dc.date.available2012-05-11T09:39:18Z
dc.date.issued2011-10
dc.date.submitted2012-05-11
dc.identifier.citationBr. J. Haematol. 2011, 155(2):235-43en_GB
dc.identifier.issn1365-2141
dc.identifier.pmid21902680
dc.identifier.doi10.1111/j.1365-2141.2011.08824.x
dc.identifier.urihttp://hdl.handle.net/2336/223192
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractThe translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols between 1992 and 2007 and have reviewed the clinical and cytogenetic characteristics of these cases, comprising 1·8% of all cases. The translocation was balanced in 15 cases (32%) and unbalanced in 29 cases (62%). The most common additional chromosome abnormalities were del(9p), i(9q), del(6q), and del(13q). The median age was 7 years, the median white blood cell (WBC) count was 16 × 10(9)/l, and the female/male ratio was 1·2. The predicted event-free survival (EFS) at 5 and 10 years was 0·79, whereas the predicted overall survival (OS) at 5 and 10 years was 0·85 and 0·82, respectively. Nine patients had a bone marrow relapse after a median of 23 months; no patient had a central nervous system relapse. Additional cytogenetic abnormalities, age, gender, WBC count or whether the t(1;19) was balanced or unbalanced did not influence EFS or OS. Compared to cases with t(12,21) and high hyperdiploidy, EFS was similar, but overall survival was worse in patients with t(1;19)/der(19)t(1;19) (P = 0·004).
dc.language.isoenen
dc.publisherWiley-Blackwellen_GB
dc.relation.urlhttp://dx.doi.org/10.1111/j.1365-2141.2011.08824.xen_GB
dc.rightsArchived with thanks to British journal of haematologyen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAneuploidyen_GB
dc.subject.meshAntineoplastic Combined Chemotherapy Protocolsen_GB
dc.subject.meshChilden_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshChromosomes, Human, Pair 1en_GB
dc.subject.meshChromosomes, Human, Pair 12en_GB
dc.subject.meshChromosomes, Human, Pair 19en_GB
dc.subject.meshChromosomes, Human, Pair 21en_GB
dc.subject.meshDisease-Free Survivalen_GB
dc.subject.meshFinlanden_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshInfanten_GB
dc.subject.meshKaplan-Meier Estimateen_GB
dc.subject.meshOncogene Proteins, Fusionen_GB
dc.subject.meshPrecursor B-Cell Lymphoblastic Leukemia-Lymphomaen_GB
dc.subject.meshPrognosisen_GB
dc.subject.meshRecurrenceen_GB
dc.subject.meshScandinaviaen_GB
dc.subject.meshTranslocation, Geneticen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titlePaediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark. mette.klarskov.andersen@rh.regionh.dken_GB
dc.identifier.journalBritish journal of haematologyen_GB
html.description.abstractThe translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols between 1992 and 2007 and have reviewed the clinical and cytogenetic characteristics of these cases, comprising 1·8% of all cases. The translocation was balanced in 15 cases (32%) and unbalanced in 29 cases (62%). The most common additional chromosome abnormalities were del(9p), i(9q), del(6q), and del(13q). The median age was 7 years, the median white blood cell (WBC) count was 16 × 10(9)/l, and the female/male ratio was 1·2. The predicted event-free survival (EFS) at 5 and 10 years was 0·79, whereas the predicted overall survival (OS) at 5 and 10 years was 0·85 and 0·82, respectively. Nine patients had a bone marrow relapse after a median of 23 months; no patient had a central nervous system relapse. Additional cytogenetic abnormalities, age, gender, WBC count or whether the t(1;19) was balanced or unbalanced did not influence EFS or OS. Compared to cases with t(12,21) and high hyperdiploidy, EFS was similar, but overall survival was worse in patients with t(1;19)/der(19)t(1;19) (P = 0·004).


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