• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Cho, Yoon Shin
Chen, Chien-Hsiun
Hu, Cheng
Long, Jirong
Ong, Rick Twee Hee
Sim, Xueling
Takeuchi, Fumihiko
Wu, Ying
Go, Min Jin
Yamauchi, Toshimasa
Chang, Yi-Cheng
Kwak, Soo Heon
Ma, Ronald C W
Yamamoto, Ken
Adair, Linda S
Aung, Tin
Cai, Qiuyin
Chang, Li-Ching
Chen, Yuan-Tsong
Gao, Yutang
Hu, Frank B
Kim, Hyung-Lae
Kim, Sangsoo
Kim, Young Jin
Lee, Jeannette Jen-Mai
Lee, Nanette R
Li, Yun
Liu, Jian Jun
Lu, Wei
Nakamura, Jiro
Nakashima, Eitaro
Ng, Daniel Peng-Keat
Tay, Wan Ting
Tsai, Fuu-Jen
Wong, Tien Yin
Yokota, Mitsuhiro
Zheng, Wei
Zhang, Rong
Wang, Congrong
So, Wing Yee
Ohnaka, Keizo
Ikegami, Hiroshi
Hara, Kazuo
Cho, Young Min
Cho, Nam H
Chang, Tien-Jyun
Bao, Yuqian
Hedman, Åsa K
Morris, Andrew P
McCarthy, Mark I
Takayanagi, Ryoichi
Park, Kyong Soo
Jia, Weiping
Chuang, Lee-Ming
Chan, Juliana C N
Maeda, Shiro
Kadowaki, Takashi
Lee, Jong-Young
Wu, Jer-Yuarn
Teo, Yik Ying
Tai, E Shyong
Shu, Xiao Ou
Mohlke, Karen L
Kato, Norihiro
Han, Bok-Ghee
Seielstad, Mark
Show allShow less
Issue Date
2012-01

Metadata
Show full item record
Citation
Nat. Genet. 2012, 44 (1):67-72
Abstract
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links
http://dx.doi.org/10.1038/ng.1019
Rights
Archived with thanks to Nature genetics
ae974a485f413a2113503eed53cd6c53
10.1038/ng.1019
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
  • Authors: Muller YL, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ
  • Issue date: 2017 May
  • Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population.
  • Authors: Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S
  • Issue date: 2013
  • East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population.
  • Authors: Zhang S, Jamaspishvili E, Tong H, Chen Y, Zhou Z, Sun L, Kazakova E, Hong Q
  • Issue date: 2019 May 30
  • Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
  • Authors: Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, Been LF, Chia KS, Dimas AS, Hassanali N, Jafar T, Jowett JB, Li X, Radha V, Rees SD, Takeuchi F, Young R, Aung T, Basit A, Chidambaram M, Das D, Grundberg E, Hedman AK, Hydrie ZI, Islam M, Khor CC, Kowlessur S, Kristensen MM, Liju S, Lim WY, Matthews DR, Liu J, Morris AP, Nica AC, Pinidiyapathirage JM, Prokopenko I, Rasheed A, Samuel M, Shah N, Shera AS, Small KS, Suo C, Wickremasinghe AR, Wong TY, Yang M, Zhang F, DIAGRAM., MuTHER., Abecasis GR, Barnett AH, Caulfield M, Deloukas P, Frayling TM, Froguel P, Kato N, Katulanda P, Kelly MA, Liang J, Mohan V, Sanghera DK, Scott J, Seielstad M, Zimmet PZ, Elliott P, Teo YY, McCarthy MI, Danesh J, Tai ES, Chambers JC
  • Issue date: 2011 Aug 28
  • A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
  • Authors: Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X, DIAGRAM Consortium., AGEN-T2D Consortium., Zhang X, Qi L, Loos RJ, Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y, Lin X
  • Issue date: 2013 Jan

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.