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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

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Authors
Ehret, Georg B
Munroe, Patricia B
Rice, Kenneth M
Bochud, Murielle
Johnson, Andrew D
Chasman, Daniel I
Smith, Albert V
Tobin, Martin D
Verwoert, Germaine C
Hwang, Shih-Jen
Pihur, Vasyl
Vollenweider, Peter
O'Reilly, Paul F
Amin, Najaf
Bragg-Gresham, Jennifer L
Teumer, Alexander
Glazer, Nicole L
Launer, Lenore
Zhao, Jing Hua
Aulchenko, Yurii
Heath, Simon
Sõber, Siim
Parsa, Afshin
Luan, Jian'an
Arora, Pankaj
Dehghan, Abbas
Zhang, Feng
Lucas, Gavin
Hicks, Andrew A
Jackson, Anne U
Peden, John F
Tanaka, Toshiko
Wild, Sarah H
Rudan, Igor
Igl, Wilmar
Milaneschi, Yuri
Parker, Alex N
Fava, Cristiano
Chambers, John C
Fox, Ervin R
Kumari, Meena
Go, Min Jin
van der Harst, Pim
Kao, Wen Hong Linda
Sjögren, Marketa
Vinay, D G
Alexander, Myriam
Tabara, Yasuharu
Shaw-Hawkins, Sue
Whincup, Peter H
Liu, Yongmei
Shi, Gang
Kuusisto, Johanna
Tayo, Bamidele
Seielstad, Mark
Sim, Xueling
Nguyen, Khanh-Dung Hoang
Lehtimäki, Terho
Matullo, Giuseppe
Wu, Ying
Gaunt, Tom R
Onland-Moret, N Charlotte
Cooper, Matthew N
Platou, Carl G P
Org, Elin
Hardy, Rebecca
Dahgam, Santosh
Palmen, Jutta
Vitart, Veronique
Braund, Peter S
Kuznetsova, Tatiana
Uiterwaal, Cuno S P M
Adeyemo, Adebowale
Palmas, Walter
Campbell, Harry
Ludwig, Barbara
Tomaszewski, Maciej
Tzoulaki, Ioanna
Palmer, Nicholette D
Aspelund, Thor
Garcia, Melissa
Chang, Yen-Pei C
O'Connell, Jeffrey R
Steinle, Nanette I
Grobbee, Diederick E
Arking, Dan E
Kardia, Sharon L
Morrison, Alanna C
Hernandez, Dena
Najjar, Samer
McArdle, Wendy L
Hadley, David
Brown, Morris J
Connell, John M
Hingorani, Aroon D
Day, Ian N M
Lawlor, Debbie A
Beilby, John P
Lawrence, Robert W
Clarke, Robert
Hopewell, Jemma C
Ongen, Halit
Dreisbach, Albert W
Li, Yali
Young, J Hunter
Bis, Joshua C
Kähönen, Mika
Viikari, Jorma
Adair, Linda S
Lee, Nanette R
Chen, Ming-Huei
Olden, Matthias
Pattaro, Cristian
Bolton, Judith A Hoffman
Köttgen, Anna
Bergmann, Sven
Mooser, Vincent
Chaturvedi, Nish
Frayling, Timothy M
Islam, Muhammad
Jafar, Tazeen H
Erdmann, Jeanette
Kulkarni, Smita R
Bornstein, Stefan R
Grässler, Jürgen
Groop, Leif
Voight, Benjamin F
Kettunen, Johannes
Howard, Philip
Taylor, Andrew
Guarrera, Simonetta
Ricceri, Fulvio
Emilsson, Valur
Plump, Andrew
Barroso, Inês
Khaw, Kay-Tee
Weder, Alan B
Hunt, Steven C
Sun, Yan V
Bergman, Richard N
Collins, Francis S
Bonnycastle, Lori L
Scott, Laura J
Stringham, Heather M
Peltonen, Leena
Perola, Markus
Vartiainen, Erkki
Brand, Stefan-Martin
Staessen, Jan A
Wang, Thomas J
Burton, Paul R
Artigas, Maria Soler
Dong, Yanbin
Snieder, Harold
Wang, Xiaoling
Zhu, Haidong
Lohman, Kurt K
Rudock, Megan E
Heckbert, Susan R
Smith, Nicholas L
Wiggins, Kerri L
Doumatey, Ayo
Shriner, Daniel
Veldre, Gudrun
Viigimaa, Margus
Kinra, Sanjay
Prabhakaran, Dorairaj
Tripathy, Vikal
Langefeld, Carl D
Rosengren, Annika
Thelle, Dag S
Corsi, Anna Maria
Singleton, Andrew
Forrester, Terrence
Hilton, Gina
McKenzie, Colin A
Salako, Tunde
Iwai, Naoharu
Kita, Yoshikuni
Ogihara, Toshio
Ohkubo, Takayoshi
Okamura, Tomonori
Ueshima, Hirotsugu
Umemura, Satoshi
Eyheramendy, Susana
Meitinger, Thomas
Wichmann, H-Erich
Cho, Yoon Shin
Kim, Hyung-Lae
Lee, Jong-Young
Scott, James
Sehmi, Joban S
Zhang, Weihua
Hedblad, Bo
Nilsson, Peter
Smith, George Davey
Wong, Andrew
Narisu, Narisu
Stančáková, Alena
Raffel, Leslie J
Yao, Jie
Kathiresan, Sekar
O'Donnell, Christopher J
Schwartz, Stephen M
Ikram, M Arfan
Longstreth, W T
Mosley, Thomas H
Seshadri, Sudha
Shrine, Nick R G
Wain, Louise V
Morken, Mario A
Swift, Amy J
Laitinen, Jaana
Prokopenko, Inga
Zitting, Paavo
Cooper, Jackie A
Humphries, Steve E
Danesh, John
Rasheed, Asif
Goel, Anuj
Hamsten, Anders
Watkins, Hugh
Bakker, Stephan J L
van Gilst, Wiek H
Janipalli, Charles S
Mani, K Radha
Yajnik, Chittaranjan S
Hofman, Albert
Mattace-Raso, Francesco U S
Oostra, Ben A
Demirkan, Ayse
Isaacs, Aaron
Rivadeneira, Fernando
Lakatta, Edward G
Orru, Marco
Scuteri, Angelo
Ala-Korpela, Mika
Kangas, Antti J
Lyytikäinen, Leo-Pekka
Soininen, Pasi
Tukiainen, Taru
Würtz, Peter
Ong, Rick Twee-Hee
Dörr, Marcus
Kroemer, Heyo K
Völker, Uwe
Völzke, Henry
Galan, Pilar
Hercberg, Serge
Lathrop, Mark
Zelenika, Diana
Deloukas, Panos
Mangino, Massimo
Spector, Tim D
Zhai, Guangju
Meschia, James F
Nalls, Michael A
Sharma, Pankaj
Terzic, Janos
Kumar, M V Kranthi
Denniff, Matthew
Zukowska-Szczechowska, Ewa
Wagenknecht, Lynne E
Fowkes, F Gerald R
Charchar, Fadi J
Schwarz, Peter E H
Hayward, Caroline
Guo, Xiuqing
Rotimi, Charles
Bots, Michiel L
Brand, Eva
Samani, Nilesh J
Polasek, Ozren
Talmud, Philippa J
Nyberg, Fredrik
Kuh, Diana
Laan, Maris
Hveem, Kristian
Palmer, Lyle J
van der Schouw, Yvonne T
Casas, Juan P
Mohlke, Karen L
Vineis, Paolo
Raitakari, Olli
Ganesh, Santhi K
Wong, Tien Y
Tai, E Shyong
Cooper, Richard S
Laakso, Markku
Rao, Dabeeru C
Harris, Tamara B
Morris, Richard W
Dominiczak, Anna F
Kivimaki, Mika
Marmot, Michael G
Miki, Tetsuro
Saleheen, Danish
Chandak, Giriraj R
Coresh, Josef
Navis, Gerjan
Salomaa, Veikko
Han, Bok-Ghee
Zhu, Xiaofeng
Kooner, Jaspal S
Melander, Olle
Ridker, Paul M
Bandinelli, Stefania
Gyllensten, Ulf B
Wright, Alan F
Wilson, James F
Ferrucci, Luigi
Farrall, Martin
Tuomilehto, Jaakko
Pramstaller, Peter P
Elosua, Roberto
Soranzo, Nicole
Sijbrands, Eric J G
Altshuler, David
Loos, Ruth J F
Shuldiner, Alan R
Gieger, Christian
Meneton, Pierre
Uitterlinden, Andre G
Wareham, Nicholas J
Gudnason, Vilmundur
Rotter, Jerome I
Rettig, Rainer
Uda, Manuela
Strachan, David P
Witteman, Jacqueline C M
Hartikainen, Anna-Liisa
Beckmann, Jacques S
Boerwinkle, Eric
Vasan, Ramachandran S
Boehnke, Michael
Larson, Martin G
Järvelin, Marjo-Riitta
Psaty, Bruce M
Abecasis, Gonçalo R
Chakravarti, Aravinda
Elliott, Paul
van Duijn, Cornelia M
Newton-Cheh, Christopher
Levy, Daniel
Caulfield, Mark J
Johnson, Toby
Thorgeirsson, G
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Issue Date
2011-10-06

Metadata
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Citation
Nature 2011, 478(7367):103-9
Abstract
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
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To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340926/?tool=pubmed
Rights
Archived with thanks to Nature
ae974a485f413a2113503eed53cd6c53
10.1038/nature10405
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English Journal Articles (Peer Reviewed)

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