Comparative long-term adverse effects elicited by invasive group B and C meningococcal infections.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Reynisson, Ingi K
Ingvarsson, Ragnar F
Nardini, Martina V
Sigurdsson, Jon F
Robbins, John B
Miller, Mark A
MetadataShow full item record
CitationClin. Infect. Dis. 2011, 53(9):e117-24
AbstractBACKGROUND: Given the identity between Neisseria meningitidis serogroup B (MenB) capsular polysaccharide (polysialic acid; PSA) and PSA found on neural cell adhesion molecules, it has been proposed that infection with MenB or vaccination with PSA may be associated with subsequent autoimmune or neurological disease. METHODS: We conducted 2 studies. The first was a retrospective nationwide study of invasive meningococcal disease (IMD) in Iceland (with 541 subjects) during the period 1975-2004, and we cross referenced this cohort with databases with respect to subsequent diagnosis of autoimmune disorders. A follow-up study involving 120 survivors of IMD was performed. The study included 70 patients with a history of MenB and 50 patients with N. meningitidis serogroup C (MenC) infection, who served as control subjects. Participants answered standardized questionnaires (Beck's Depression Inventory [BDI] II, Depression Anxiety Stress Scales [DASS], and Patient Health Questionnaire [PHQ]), and serum levels of immunoglobulin (Ig) G against MenB and MenC capsular polysaccharides were measured. RESULTS: The nationwide cohort had 9166 patient-years of follow up. No evidence of increased autoimmunity was found to be associated with MenB, compared with MenC. In the follow-up study, patients were evaluated 16.6 years after the infection, representing 2022 patient-years of observation. Comparable rates of most complications were recorded, but MenC infections were associated with arthritis (P = .008) and migraine headaches (P = .01) more frequently than were MenB infections. No difference was observed with respect to scores on BDI-II, DASS, or PHQ. IgG anti-MenB and anti-MenC capsular polysaccharide levels were not related to patient complaints. CONCLUSIONS: This study does not support the hypothesis that MenB infection may predispose to autoimmunity. MenC infections are associated with a higher prevalence of arthritis and migraine headaches. No evidence of antibody-associated pathology was detected at long-term follow-up.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Epidemiology of invasive meningococcal B disease in Australia, 1999-2015: priority populations for vaccination.
- Authors: Archer BN, Chiu CK, Jayasinghe SH, Richmond PC, McVernon J, Lahra MM, Andrews RM, McIntyre PB, Australian Technical Advisory Group on Immunisation (ATAGI) Meningococcal Working Party.
- Issue date: 2017 Nov 6
- Kinetics of the long-term antibody response after meningococcal C vaccination in patients with juvenile idiopathic arthritis: a retrospective cohort study.
- Authors: Stoof SP, Heijstek MW, Sijssens KM, van der Klis F, Sanders EA, Teunis PF, Wulffraat NM, Berbers GA
- Issue date: 2014 Apr
- Antibody responses to the capsular polysaccharide of Neisseria meningitidis serogroup B in patients with meningococcal disease.
- Authors: Granoff DM, Kelsey SK, Bijlmer HA, Van Alphen L, Dankert J, Mandrell RE, Azmi FH, Scholten RJ
- Issue date: 1995 Sep
- Lack of association between group B meningococcal disease and autoimmune disease.
- Authors: Howitz M, Krause TG, Simonsen JB, Hoffmann S, Frisch M, Nielsen NM, Robbins J, Schneerson R, Mølbak K, Miller MA
- Issue date: 2007 Nov 15
- Characterization of invasive Neisseria meningitidis strains from Québec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets.
- Authors: Law DK, Lefebvre B, Gilca R, Deng S, Zhou J, De Wals P, Tsang RS
- Issue date: 2015 Jul 25