SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsHanly, J G
Urowitz, M B
Bae, S C
Wallace, D J
Merrill, J T
Fortin, P R
Gladman, D D
Bruce, I N
Alarcón, G S
Dooley, M A
Van Vollenhoven, R
MetadataShow full item record
CitationAnn. Rheum. Dis. 2011, 70(6):961-7
AbstractOBJECTIVE: To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). METHODS: An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. RESULTS: 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3 ± 2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p<0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were +1.73 (0.71) and -0.62 (1.58) (p<0.05), respectively. Changes in SF-36 subscales were in the same direction (p<0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. CONCLUSION: Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to Annals of the rheumatic diseases
- Outcomes of neuropsychiatric events in systemic lupus erythematosus based on clinical phenotypes; prospective data from the Leiden NP SLE cohort.
- Authors: Magro-Checa C, Beaart-van de Voorde LJ, Middelkoop HA, Dane ML, van der Wee NJ, van Buchem MA, Huizinga TW, Steup-Beekman GM
- Issue date: 2017 Apr
- Long-term outcome of early neuropsychiatric events due to active disease in systemic lupus erythematosus.
- Authors: Wang M, Gladman DD, Ibañez D, Urowitz MB
- Issue date: 2012 Jun
- Prospective study of neuropsychiatric events in systemic lupus erythematosus.
- Authors: Hanly JG, Su L, Farewell V, McCurdy G, Fougere L, Thompson K
- Issue date: 2009 Jul
- Neuropsychiatric events in systemic lupus erythematosus: attribution and clinical significance.
- Authors: Hanly JG, McCurdy G, Fougere L, Douglas JA, Thompson K
- Issue date: 2004 Nov
- Neuropsychiatric symptoms in systemic lupus erythematosus: impact on quality of life.
- Authors: Monahan RC, Beaart-van de Voorde LJJ, Steup-Beekman GM, Magro-Checa C, Huizinga TWJ, Hoekman J, Kaptein AA
- Issue date: 2017 Oct