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dc.contributor.authorHastan, D
dc.contributor.authorFokkens, W J
dc.contributor.authorBachert, C
dc.contributor.authorNewson, R B
dc.contributor.authorBislimovska, J
dc.contributor.authorBockelbrink, A
dc.contributor.authorBousquet, P J
dc.contributor.authorBrozek, G
dc.contributor.authorBruno, A
dc.contributor.authorDahlén, S E
dc.contributor.authorForsberg, B
dc.contributor.authorGunnbjörnsdóttir, M
dc.contributor.authorKasper, L
dc.contributor.authorKrämer, U
dc.contributor.authorKowalski, M L
dc.contributor.authorLange, B
dc.contributor.authorLundbäck, B
dc.contributor.authorSalagean, E
dc.contributor.authorTodo-Bom, A
dc.contributor.authorTomassen, P
dc.contributor.authorToskala, E
dc.contributor.authorvan Drunen, C M
dc.contributor.authorBousquet, J
dc.contributor.authorZuberbier, T
dc.contributor.authorJarvis, D
dc.contributor.authorBurney, P
dc.date.accessioned2012-05-22T14:22:04Z
dc.date.available2012-05-22T14:22:04Z
dc.date.issued2011-09
dc.date.submitted2012-05-22
dc.identifier.citationAllergy 2011, 66(9):1216-23en_GB
dc.identifier.issn1398-9995
dc.identifier.pmid21605125
dc.identifier.doi10.1111/j.1398-9995.2011.02646.x
dc.identifier.urihttp://hdl.handle.net/2336/225297
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractBACKGROUND: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this study, conducted by the GA²LEN network of excellence, the European Position Paper on Rhinosinusitis and nasal Polyps (EP³OS) diagnostic criteria are applied to estimate variation in the prevalence of Chronic rhinosinusitis (CRS) for Europe. METHOD: A postal questionnaire was sent to a random sample of adults aged 15-75 years in 19 centres in Europe. Participants reported symptoms of CRS, and doctor diagnosed CRS, allergic rhinitis, age, gender and smoking history. Definition of CRS was based on the EP³OS diagnostic criteria: the presence of more than two of the symptoms: (i) nasal blockage, (ii) nasal discharge, (iii) facial pain/pressure or (iv) reduction in sense of smell, for >12 weeks in the past year--with at least one symptom being nasal blockage or discharge. RESULTS: Information was obtained from 57,128 responders living in 19 centres in 12 countries. The overall prevalence of CRS by EP³OS criteria was 10.9% (range 6.9-27.1). CRS was more common in smokers than in nonsmokers (OR 1.7: 95% CI 1.6-1.9). The prevalence of self-reported physician-diagnosed CRS within centres was highly correlated with the prevalence of EP³OS-diagnosed CRS. CONCLUSION: This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe.
dc.description.sponsorshipEuropean Union FOOD-CT-2004-506378en_GB
dc.language.isoenen
dc.publisherWiley-Blackwellen_GB
dc.relation.urlhttp://dx.doi.org/10.1111/j.1398-9995.2011.02646.xen_GB
dc.rightsArchived with thanks to Allergyen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshChronic Diseaseen_GB
dc.subject.meshEuropeen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNasal Polypsen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshRhinitisen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSinusitisen_GB
dc.subject.meshYoung Adulten_GB
dc.titleChronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.en_GB
dc.identifier.journalAllergyen_GB
html.description.abstractBACKGROUND: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this study, conducted by the GA²LEN network of excellence, the European Position Paper on Rhinosinusitis and nasal Polyps (EP³OS) diagnostic criteria are applied to estimate variation in the prevalence of Chronic rhinosinusitis (CRS) for Europe. METHOD: A postal questionnaire was sent to a random sample of adults aged 15-75 years in 19 centres in Europe. Participants reported symptoms of CRS, and doctor diagnosed CRS, allergic rhinitis, age, gender and smoking history. Definition of CRS was based on the EP³OS diagnostic criteria: the presence of more than two of the symptoms: (i) nasal blockage, (ii) nasal discharge, (iii) facial pain/pressure or (iv) reduction in sense of smell, for >12 weeks in the past year--with at least one symptom being nasal blockage or discharge. RESULTS: Information was obtained from 57,128 responders living in 19 centres in 12 countries. The overall prevalence of CRS by EP³OS criteria was 10.9% (range 6.9-27.1). CRS was more common in smokers than in nonsmokers (OR 1.7: 95% CI 1.6-1.9). The prevalence of self-reported physician-diagnosed CRS within centres was highly correlated with the prevalence of EP³OS-diagnosed CRS. CONCLUSION: This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe.


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