Increased cancer risks among arthroplasty patients: 30 year follow-up of the Swedish Knee Arthroplasty Register.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationEur. J. Cancer 2011, 47(7):1061-71
ÚtdrátturBACKGROUND: An increasing number of young patients are undergoing knee arthroplasties. Thus, the long-term risks of having a knee prosthesis must be evaluated. This study focuses on the potential carcinogenic effects of the prosthesis; it is a long-term follow-up of all patients in Sweden between 1975 and 2006. METHODS: The incidence of cancer in a total population of operated individuals was compared to the overall national cancer incidence in Sweden by means of standardised incidence ratios. Analysis of cancer latency period was performed to identify potential aetiological factors. RESULTS: For male and female patients with rheumatoid arthritis (RA) or osteoarthritis (OA), the overall cancer risks were elevated, ranging from 1.10 (95% confidence interval (CI): 1.03-1.18) for men with OA to 1.26 (1.23-1.29) for men with RA. The greatest increases in risk were observed for the leukaemia subtypes, myelodysplastic syndromes (MDS) and essential thrombocytosis (ET), ranging from 3.31 (1.24-8.83) for ET in men with OA to 7.38 (1.85-29.51) for ET in women with RA. Increases in risk were also observed for breast cancer, prostate cancer and melanoma. The latency analysis revealed elevated risks late in the study period for both solid and haematopoietic cancers. However, only increases in MDS and possibly prostate cancer and melanoma rates appeared to be connected to the operation. CONCLUSION: This study showed that OA and RA arthroplasty patients have a significantly higher risk of cancer than the general population. Elevated risks of MDS and possibly prostate cancer and melanoma indicated a potential connection to exposure to metals in the implant. The observed excessive incidence of ET was likely associated with the inflammatory disease.
Lu00FDsingTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to European journal of cancer (Oxford, England : 1990)
- Incidence of cancer among patients with knee implants in Sweden, 1980-1994.
- Authors: Fryzek JP, Ye W, Signorello LB, Lipworth L, Blot WJ, McLaughlin JK, Nyren O
- Issue date: 2002 Jun 1
- Do rheumatoid arthritis and lymphoma share risk factors?: a comparison of lymphoma and cancer risks before and after diagnosis of rheumatoid arthritis.
- Authors: Hellgren K, Smedby KE, Feltelius N, Baecklund E, Askling J
- Issue date: 2010 May
- Occupation and cancer - follow-up of 15 million people in five Nordic countries.
- Authors: Pukkala E, Martinsen JI, Lynge E, Gunnarsdottir HK, Sparén P, Tryggvadottir L, Weiderpass E, Kjaerheim K
- Issue date: 2009
- Survival of the AGC total knee arthroplasty is similar for arthrosis and rheumatoid arthritis. Finnish Arthroplasty Register report on 8,467 operations carried out between 1985 and 1999.
- Authors: Himanen AK, Belt E, Nevalainen J, Hämäläinen M, Lehto MU
- Issue date: 2005 Feb
- Evaluation of bias in familial risk estimates: a study of common cancers using Swedish population-based registers.
- Authors: Leu M, Reilly M, Czene K
- Issue date: 2008 Sep 17