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dc.contributor.authorTomassen, P
dc.contributor.authorNewson, R B
dc.contributor.authorHoffmans, R
dc.contributor.authorLötvall, J
dc.contributor.authorCardell, L O
dc.contributor.authorGunnbjörnsdóttir, M
dc.contributor.authorThilsing, T
dc.contributor.authorMatricardi, P
dc.contributor.authorKrämer, U
dc.contributor.authorMakowska, J S
dc.contributor.authorBrozek, G
dc.contributor.authorGjomarkaj, M
dc.contributor.authorHowarth, P
dc.contributor.authorLoureiro, C
dc.contributor.authorToskala, E
dc.contributor.authorFokkens, W
dc.contributor.authorBachert, C
dc.contributor.authorBurney, P
dc.contributor.authorJarvis, D
dc.date.accessioned2012-05-29T11:26:21Z
dc.date.available2012-05-29T11:26:21Z
dc.date.issued2011-04
dc.date.submitted2012-05-22
dc.identifier.citationAllergy 2011, 66(4):556-61en_GB
dc.identifier.issn1398-9995
dc.identifier.pmid21083566
dc.identifier.doi10.1111/j.1398-9995.2010.02503.x
dc.identifier.urihttp://hdl.handle.net/2336/226398
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractBACKGROUND: The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic, endoscopic, and radiologic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies, the definition is based on symptoms only. We aimed to assess the reliability and validity of a symptom-based definition of CRS using data from the GA(2) LEN European survey. METHODS: On two separate occasions, 1700 subjects from 11 centers provided information on symptoms of CRS, allergic rhinitis, and asthma. CRS was defined by the epidemiological EP3OS symptom criteria. The difference in prevalence of CRS between two study points, the standardized absolute repeatability, and the chance-corrected repeatability (kappa) were determined. In two centers, 342 participants underwent nasal endoscopy. The association of symptom-based CRS with endoscopy and self-reported doctor-diagnosed CRS was assessed. RESULTS: There was a decrease in prevalence of CRS between the two study phases, and this was consistent across all centers (-3.0%, 95% CI: -5.0 to -1.0%, I(2) = 0). There was fair to moderate agreement between the two occasions (kappa = 39.6). Symptom-based CRS was significantly associated with positive endoscopy in nonallergic subjects, and with self-reported doctor-diagnosed CRS in all subjects, irrespective of the presence of allergic rhinitis. CONCLUSION: Our findings suggest that a symptom-based definition of CRS, according to the epidemiological part of the EP3OS criteria, has a moderate reliability over time, is stable between study centers, is not influenced by the presence of allergic rhinitis, and is suitable for the assessment of geographic variation in prevalence of CRS.
dc.description.sponsorshipSixth European Union Framework program for research FOOD-CT-2004-506378en_GB
dc.language.isoenen
dc.publisherWileyen_GB
dc.relation.urlhttp://dx.doi.org/10.1111/j.1398-9995.2010.02503.xen_GB
dc.rightsArchived with thanks to Allergyen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshChronic Diseaseen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshEndoscopyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshRhinitis, Allergic, Perennialen_GB
dc.subject.meshSinusitisen_GB
dc.subject.meshYoung Adulten_GB
dc.titleReliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis--a GA² LEN study.en
dc.typeArticleen
dc.contributor.departmentUpper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic-Audiologic Science, Ghent University, Gent, Belgium. peter.tomassen@ugent.been_GB
dc.identifier.journalAllergyen_GB
html.description.abstractBACKGROUND: The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic, endoscopic, and radiologic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies, the definition is based on symptoms only. We aimed to assess the reliability and validity of a symptom-based definition of CRS using data from the GA(2) LEN European survey. METHODS: On two separate occasions, 1700 subjects from 11 centers provided information on symptoms of CRS, allergic rhinitis, and asthma. CRS was defined by the epidemiological EP3OS symptom criteria. The difference in prevalence of CRS between two study points, the standardized absolute repeatability, and the chance-corrected repeatability (kappa) were determined. In two centers, 342 participants underwent nasal endoscopy. The association of symptom-based CRS with endoscopy and self-reported doctor-diagnosed CRS was assessed. RESULTS: There was a decrease in prevalence of CRS between the two study phases, and this was consistent across all centers (-3.0%, 95% CI: -5.0 to -1.0%, I(2) = 0). There was fair to moderate agreement between the two occasions (kappa = 39.6). Symptom-based CRS was significantly associated with positive endoscopy in nonallergic subjects, and with self-reported doctor-diagnosed CRS in all subjects, irrespective of the presence of allergic rhinitis. CONCLUSION: Our findings suggest that a symptom-based definition of CRS, according to the epidemiological part of the EP3OS criteria, has a moderate reliability over time, is stable between study centers, is not influenced by the presence of allergic rhinitis, and is suitable for the assessment of geographic variation in prevalence of CRS.


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