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Risk factors of autistic symptoms in children with ADHD.

dc.contributor.authorKröger, Anne
dc.contributor.authorHänig, Susann
dc.contributor.authorSeitz, Christiane
dc.contributor.authorPalmason, Haukur
dc.contributor.authorMeyer, Jobst
dc.contributor.authorFreitag, Christine M
dc.date.accessioned2012-06-04T10:59:12Z
dc.date.available2012-06-04T10:59:12Z
dc.date.issued2011-12
dc.date.submitted2012-06-04
dc.identifier.citationEur. Child Adolesc. Psychiatry 2011, 20(11-12):561-70en_GB
dc.identifier.issn1435-165X
dc.identifier.pmid22002011
dc.identifier.doi10.1007/s00787-011-0221-1
dc.identifier.urihttp://hdl.handle.net/2336/227412
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractAutistic symptoms are frequently observed in children with attention-deficit/hyperactivity disorder (ADHD), but their etiology remains unclear. The main aim of this study was to describe risk factors for increased autistic symptoms in children with ADHD without an autism or autism-spectrum diagnosis. Comorbid psychiatric disorders, developmental delay, current medication, prenatal biological and postnatal psychosocial risk factors as well as parental autistic traits were assessed in 205 children with ADHD. Linear regression models identified maternal autistic traits, current familial risk factors and hyperactive symptoms as predictors of autistic symptoms in children with ADHD. Findings are indicative of possible genetic as well as environmental risk factors mediating autistic symptoms in children with ADHD. An additional validity analysis by ROC, area under the curve (AUC), suggested a cut-off of 11 to differentiate between ADHD and high-functioning ASD by the Social Communication Questionnaire (SCQ).
dc.description.sponsorshipDeutsche Forschungsgemeinschaft ME 1923/5-1 ME 1923/5-3 GRK 1389/1 Saarland University T6 03 10 00 - 45en_GB
dc.language.isoenen
dc.publisherDr. Dietrich Steinkopff Verlagen_GB
dc.relation.urlhttp://dx.doi.org/10.1007/s00787-011-0221-1en_GB
dc.rightsArchived with thanks to European child & adolescent psychiatryen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshArea Under Curveen_GB
dc.subject.meshAttention Deficit Disorder with Hyperactivityen_GB
dc.subject.meshAutistic Disorderen_GB
dc.subject.meshChilden_GB
dc.subject.meshChild Development Disorders, Pervasiveen_GB
dc.subject.meshComorbidityen_GB
dc.subject.meshDiagnosis, Differentialen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMothersen_GB
dc.subject.meshParentsen_GB
dc.subject.meshPsychiatric Status Rating Scalesen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshROC Curveen_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshRisk Factorsen_GB
dc.titleRisk factors of autistic symptoms in children with ADHD.en
dc.typeArticleen
dc.contributor.departmentDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Frankfurt/Main, Germany. AKroeger@med.uni-frankfurt.deen_GB
dc.identifier.journalEuropean child & adolescent psychiatryen_GB
html.description.abstractAutistic symptoms are frequently observed in children with attention-deficit/hyperactivity disorder (ADHD), but their etiology remains unclear. The main aim of this study was to describe risk factors for increased autistic symptoms in children with ADHD without an autism or autism-spectrum diagnosis. Comorbid psychiatric disorders, developmental delay, current medication, prenatal biological and postnatal psychosocial risk factors as well as parental autistic traits were assessed in 205 children with ADHD. Linear regression models identified maternal autistic traits, current familial risk factors and hyperactive symptoms as predictors of autistic symptoms in children with ADHD. Findings are indicative of possible genetic as well as environmental risk factors mediating autistic symptoms in children with ADHD. An additional validity analysis by ROC, area under the curve (AUC), suggested a cut-off of 11 to differentiate between ADHD and high-functioning ASD by the Social Communication Questionnaire (SCQ).


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