• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Exploring the link between MORF4L1 and risk of breast cancer.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Martrat, Griselda
Maxwell, Christopher M
Tominaga, Emiko
Porta-de-la-Riva, Montserrat
Bonifaci, Núria
Gómez-Baldó, Laia
Bogliolo, Massimo
Lázaro, Conxi
Blanco, Ignacio
Brunet, Joan
Aguilar, Helena
Fernández-Rodríguez, Juana
Seal, Sheila
Renwick, Anthony
Rahman, Nazneen
Kühl, Julia
Neveling, Kornelia
Schindler, Detlev
Ramírez, María J
Castellà, María
Hernández, Gonzalo
Easton, Douglas F
Peock, Susan
Cook, Margaret
Oliver, Clare T
Frost, Debra
Platte, Radka
Evans, D Gareth
Lalloo, Fiona
Eeles, Rosalind
Izatt, Louise
Chu, Carol
Davidson, Rosemarie
Ong, Kai-Ren
Cook, Jackie
Douglas, Fiona
Hodgson, Shirley
Brewer, Carole
Morrison, Patrick J
Porteous, Mary
Peterlongo, Paolo
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Roversi, Gaia
Barile, Monica
Viel, Alessandra
Pasini, Barbara
Ottini, Laura
Putignano, Anna Laura
Savarese, Antonella
Bernard, Loris
Radice, Paolo
Healey, Sue
Spurdle, Amanda
Chen, Xiaoqing
Beesley, Jonathan
Rookus, Matti A
Verhoef, Senno
Tilanus-Linthorst, Madeleine A
Vreeswijk, Maaike P
Asperen, Christi J
Bodmer, Danielle
Ausems, Margreet G E M
van Os, Theo A
Blok, Marinus J
Meijers-Heijboer, Hanne E J
Hogervorst, Frans B L
Goldgar, David E
Buys, Saundra
John, Esther M
Miron, Alexander
Southey, Melissa
Daly, Mary B
Harbst, Katja
Borg, Ake
Rantala, Johanna
Barbany-Bustinza, Gisela
Ehrencrona, Hans
Stenmark-Askmalm, Marie
Kaufman, Bella
Laitman, Yael
Milgrom, Roni
Friedman, Eitan
Domchek, Susan M
Nathanson, Katherine L
Rebbeck, Timothy R
Johannsson, Oskar Thor
Couch, Fergus J
Wang, Xianshu
Fredericksen, Zachary
Cuadras, Daniel
Moreno, Víctor
Pientka, Friederike K
Depping, Reinhard
Caldés, Trinidad
Osorio, Ana
Benítez, Javier
Bueren, Juan
Heikkinen, Tuomas
Nevanlinna, Heli
Hamann, Ute
Torres, Diana
Caligo, Maria Adelaide
Godwin, Andrew K
Imyanitov, Evgeny N
Janavicius, Ramunas
Sinilnikova, Olga M
Stoppa-Lyonnet, Dominique
Mazoyer, Sylvie
Verny-Pierre, Carole
Castera, Laurent
de Pauw, Antoine
Bignon, Yves-Jean
Uhrhammer, Nancy
Peyrat, Jean-Philippe
Vennin, Philippe
Ferrer, Sandra Fert
Collonge-Rame, Marie-Agnès
Mortemousque, Isabelle
McGuffog, Lesley
Chenevix-Trench, Georgia
Pereira-Smith, Olivia M
Antoniou, Antonis C
Cerón, Julián
Tominaga, Kaoru
Surrallés, Jordi
Pujana, Miguel Angel
Show allShow less
Issue Date
2011

Metadata
Show full item record
Citation
Breast Cancer Res. 2011, 13(2):R40
Abstract
INTRODUCTION: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. METHODS: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. RESULTS: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to γ-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively. CONCLUSIONS: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links
http://dx.doi.org/10.1186/bcr2862
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219203/?tool=pubmed
Rights
Archived with thanks to Breast cancer research : BCR
ae974a485f413a2113503eed53cd6c53
10.1186/bcr2862
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
  • Authors: Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR
  • Issue date: 2010 Apr 1
  • Breast cancer and Fanconi anemia: what are the connections?
  • Authors: Zdzienicka MZ, Arwert F
  • Issue date: 2002 Oct
  • Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
  • Authors: Park JY, Singh TR, Nassar N, Zhang F, Freund M, Hanenberg H, Meetei AR, Andreassen PR
  • Issue date: 2014 Oct 2
  • Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
  • Authors: Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM
  • Issue date: 2013 May 21
  • Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.
  • Authors: Kuusisto KM, Bebel A, Vihinen M, Schleutker J, Sallinen SL
  • Issue date: 2011 Feb 28

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.