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dc.contributor.authorOlafsdottir, Olof Birna
dc.contributor.authorHardarson, Sveinn Hakon
dc.contributor.authorGottfredsdottir, Maria Soffia
dc.contributor.authorHarris, Alon
dc.contributor.authorStefánsson, Einar
dc.date.accessioned2012-06-05T14:26:24Z
dc.date.available2012-06-05T14:26:24Z
dc.date.issued2011-08
dc.date.submitted2012-06-05
dc.identifier.citationInvest. Ophthalmol. Vis. Sci. 2011, 52(9):6409-13en_GB
dc.identifier.issn1552-5783
dc.identifier.pmid21715353
dc.identifier.doi10.1167/iovs.10-6985
dc.identifier.urihttp://hdl.handle.net/2336/227572
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractPURPOSE. To determine whether retinal vessel oxygen saturation is affected in primary open-angle glaucoma (POAG) patients. METHODS. Retinal oxygen saturation in patients with POAG was measured in retinal vessels with a spectrophotometric retinal oximeter in darkness, and visual fields were obtained. Oxygen tension (Po(2)) was calculated from oxygen saturation values. Statistical analysis was performed using Pearson's correlation and Student's t-test. RESULTS. Mean oxygen saturation in venules was higher in persons with poor visual fields (68% ± 4%, mean ± SD) than in those with good visual fields (62% ± 3%; P = 0.0018). The mean arteriovenous difference in oxygen saturation was lower in persons with poor visual fields (30% ± 4%, n = 9) than in those with good visual fields (37% ± 4%; P = 0.0003; n = 12). No correlation was found between saturation in retinal arterioles and visual field mean defect (n = 31; r = -0.16; P = 0.38). Oxygen saturation in retinal venules correlated positively with worsening visual field mean defect (r = 0.43; P = 0.015). Arteriovenous difference in oxygen saturation decreased significantly as the visual field mean defect worsened (r = -0.55; P = 0.0013). Mean Po(2) in venules was 38 ± 3 mm Hg. It was significantly higher in persons with poor visual field fields (40 ± 3 mm Hg) than in those with good visual fields (36 ± 2 mm Hg; P = 0.0016). CONCLUSIONS. Deeper glaucomatous visual field defects are associated with increased oxygen saturation in venules and decreased arteriovenous difference in retinal oxygen saturation. The data suggest that oxygen metabolism is affected in the glaucomatous retina, possibly related to tissue atrophy.
dc.description.sponsorshipIcelandic Centre for Research (Rannis) Icelandic Fund for Prevention of Blindness Landspitali-University Hospitalen_GB
dc.language.isoenen
dc.publisherAssociation For Research In Vision And Ophthalmology (Arvo)en_GB
dc.relation.urlhttp://dx.doi.org/10.1167/iovs.10-6985en_GB
dc.rightsArchived with thanks to Investigative ophthalmology & visual scienceen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAntihypertensive Agentsen_GB
dc.subject.meshArteriolesen_GB
dc.subject.meshBlood Pressureen_GB
dc.subject.meshDark Adaptationen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGlaucoma, Open-Angleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIntraocular Pressureen_GB
dc.subject.meshMaleen_GB
dc.subject.meshOximetryen_GB
dc.subject.meshOxygenen_GB
dc.subject.meshOxygen Consumptionen_GB
dc.subject.meshPartial Pressureen_GB
dc.subject.meshRetinal Vesselsen_GB
dc.subject.meshVenulesen_GB
dc.subject.meshVision Disordersen_GB
dc.subject.meshVisual Fieldsen_GB
dc.titleRetinal oximetry in primary open-angle glaucoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, University of Iceland, Reykjavik.en_GB
dc.identifier.journalInvestigative ophthalmology & visual scienceen_GB
html.description.abstractPURPOSE. To determine whether retinal vessel oxygen saturation is affected in primary open-angle glaucoma (POAG) patients. METHODS. Retinal oxygen saturation in patients with POAG was measured in retinal vessels with a spectrophotometric retinal oximeter in darkness, and visual fields were obtained. Oxygen tension (Po(2)) was calculated from oxygen saturation values. Statistical analysis was performed using Pearson's correlation and Student's t-test. RESULTS. Mean oxygen saturation in venules was higher in persons with poor visual fields (68% ± 4%, mean ± SD) than in those with good visual fields (62% ± 3%; P = 0.0018). The mean arteriovenous difference in oxygen saturation was lower in persons with poor visual fields (30% ± 4%, n = 9) than in those with good visual fields (37% ± 4%; P = 0.0003; n = 12). No correlation was found between saturation in retinal arterioles and visual field mean defect (n = 31; r = -0.16; P = 0.38). Oxygen saturation in retinal venules correlated positively with worsening visual field mean defect (r = 0.43; P = 0.015). Arteriovenous difference in oxygen saturation decreased significantly as the visual field mean defect worsened (r = -0.55; P = 0.0013). Mean Po(2) in venules was 38 ± 3 mm Hg. It was significantly higher in persons with poor visual field fields (40 ± 3 mm Hg) than in those with good visual fields (36 ± 2 mm Hg; P = 0.0016). CONCLUSIONS. Deeper glaucomatous visual field defects are associated with increased oxygen saturation in venules and decreased arteriovenous difference in retinal oxygen saturation. The data suggest that oxygen metabolism is affected in the glaucomatous retina, possibly related to tissue atrophy.


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