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dc.contributor.authorSchunkert, Heribert
dc.contributor.authorKönig, Inke R
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorReilly, Muredach P
dc.contributor.authorAssimes, Themistocles L
dc.contributor.authorHolm, Hilma
dc.contributor.authorPreuss, Michael
dc.contributor.authorStewart, Alexandre F R
dc.contributor.authorBarbalic, Maja
dc.contributor.authorGieger, Christian
dc.contributor.authorAbsher, Devin
dc.contributor.authorAherrahrou, Zouhair
dc.contributor.authorAllayee, Hooman
dc.contributor.authorAltshuler, David
dc.contributor.authorAnand, Sonia S
dc.contributor.authorAndersen, Karl
dc.contributor.authorAnderson, Jeffrey L
dc.contributor.authorArdissino, Diego
dc.contributor.authorBall, Stephen G
dc.contributor.authorBalmforth, Anthony J
dc.contributor.authorBarnes, Timothy A
dc.contributor.authorBecker, Diane M
dc.contributor.authorBecker, Lewis C
dc.contributor.authorBerger, Klaus
dc.contributor.authorBis, Joshua C
dc.contributor.authorBoekholdt, S Matthijs
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBraund, Peter S
dc.contributor.authorBrown, Morris J
dc.contributor.authorBurnett, Mary Susan
dc.contributor.authorBuysschaert, Ian
dc.contributor.authorCarlquist, John F
dc.contributor.authorChen, Li
dc.contributor.authorCichon, Sven
dc.contributor.authorCodd, Veryan
dc.contributor.authorDavies, Robert W
dc.contributor.authorDedoussis, George
dc.contributor.authorDehghan, Abbas
dc.contributor.authorDemissie, Serkalem
dc.contributor.authorDevaney, Joseph M
dc.contributor.authorDiemert, Patrick
dc.contributor.authorDo, Ron
dc.contributor.authorDoering, Angela
dc.contributor.authorEifert, Sandra
dc.contributor.authorMokhtari, Nour Eddine El
dc.contributor.authorEllis, Stephen G
dc.contributor.authorElosua, Roberto
dc.contributor.authorEngert, James C
dc.contributor.authorEpstein, Stephen E
dc.contributor.authorde Faire, Ulf
dc.contributor.authorFischer, Marcus
dc.contributor.authorFolsom, Aaron R
dc.contributor.authorFreyer, Jennifer
dc.contributor.authorGigante, Bruna
dc.contributor.authorGirelli, Domenico
dc.contributor.authorGretarsdottir, Solveig
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorGulcher, Jeffrey R
dc.contributor.authorHalperin, Eran
dc.contributor.authorHammond, Naomi
dc.contributor.authorHazen, Stanley L
dc.contributor.authorHofman, Albert
dc.contributor.authorHorne, Benjamin D
dc.contributor.authorIllig, Thomas
dc.contributor.authorIribarren, Carlos
dc.contributor.authorJones, Gregory T
dc.contributor.authorJukema, J Wouter
dc.contributor.authorKaiser, Michael A
dc.contributor.authorKaplan, Lee M
dc.contributor.authorKastelein, John J P
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKnowles, Joshua W
dc.contributor.authorKolovou, Genovefa
dc.contributor.authorKong, Augustine
dc.contributor.authorLaaksonen, Reijo
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLeander, Karin
dc.contributor.authorLettre, Guillaume
dc.contributor.authorLi, Mingyao
dc.contributor.authorLieb, Wolfgang
dc.contributor.authorLoley, Christina
dc.contributor.authorLotery, Andrew J
dc.contributor.authorMannucci, Pier M
dc.contributor.authorMaouche, Seraya
dc.contributor.authorMartinelli, Nicola
dc.contributor.authorMcKeown, Pascal P
dc.contributor.authorMeisinger, Christa
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMelander, Olle
dc.contributor.authorMerlini, Pier Angelica
dc.contributor.authorMooser, Vincent
dc.contributor.authorMorgan, Thomas
dc.contributor.authorMühleisen, Thomas W
dc.contributor.authorMuhlestein, Joseph B
dc.contributor.authorMünzel, Thomas
dc.contributor.authorMusunuru, Kiran
dc.contributor.authorNahrstaedt, Janja
dc.contributor.authorNelson, Christopher P
dc.contributor.authorNöthen, Markus M
dc.contributor.authorOlivieri, Oliviero
dc.contributor.authorPatel, Riyaz S
dc.contributor.authorPatterson, Chris C
dc.contributor.authorPeters, Annette
dc.contributor.authorPeyvandi, Flora
dc.contributor.authorQu, Liming
dc.contributor.authorQuyyumi, Arshed A
dc.contributor.authorRader, Daniel J
dc.contributor.authorRallidis, Loukianos S
dc.contributor.authorRice, Catherine
dc.contributor.authorRosendaal, Frits R
dc.contributor.authorRubin, Diana
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSampietro, M Lourdes
dc.contributor.authorSandhu, Manj S
dc.contributor.authorSchadt, Eric
dc.contributor.authorSchäfer, Arne
dc.contributor.authorSchillert, Arne
dc.contributor.authorSchreiber, Stefan
dc.contributor.authorSchrezenmeir, Jürgen
dc.contributor.authorSchwartz, Stephen M
dc.contributor.authorSiscovick, David S
dc.contributor.authorSivananthan, Mohan
dc.contributor.authorSivapalaratnam, Suthesh
dc.contributor.authorSmith, Albert
dc.contributor.authorSmith, Tamara B
dc.contributor.authorSnoep, Jaapjan D
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorSpertus, John A
dc.contributor.authorStark, Klaus
dc.contributor.authorStirrups, Kathy
dc.contributor.authorStoll, Monika
dc.contributor.authorTang, W H Wilson
dc.contributor.authorTennstedt, Stephanie
dc.contributor.authorThorgeirsson, Gudmundur
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorTomaszewski, Maciej
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorvan Rij, Andre M
dc.contributor.authorVoight, Benjamin F
dc.contributor.authorWareham, Nick J
dc.contributor.authorWells, George A
dc.contributor.authorWichmann, H-Erich
dc.contributor.authorWild, Philipp S
dc.contributor.authorWillenborg, Christina
dc.contributor.authorWitteman, Jaqueline C M
dc.contributor.authorWright, Benjamin J
dc.contributor.authorYe, Shu
dc.contributor.authorZeller, Tanja
dc.contributor.authorZiegler, Andreas
dc.contributor.authorCambien, Francois
dc.contributor.authorGoodall, Alison H
dc.contributor.authorCupples, L Adrienne
dc.contributor.authorQuertermous, Thomas
dc.contributor.authorMärz, Winfried
dc.contributor.authorHengstenberg, Christian
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorOuwehand, Willem H
dc.contributor.authorHall, Alistair S
dc.contributor.authorDeloukas, Panos
dc.contributor.authorThompson, John R
dc.contributor.authorStefansson, Kari
dc.contributor.authorRoberts, Robert
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorO'Donnell, Christopher J
dc.contributor.authorMcPherson, Ruth
dc.contributor.authorErdmann, Jeanette
dc.contributor.authorSamani, Nilesh J
dc.date.accessioned2012-06-07T11:21:05Z
dc.date.available2012-06-07T11:21:05Z
dc.date.issued2011-04
dc.date.submitted2012-06-07
dc.identifier.citationNat. Genet. 2011, 43(4):333-8en_GB
dc.identifier.issn1546-1718
dc.identifier.pmid21378990
dc.identifier.doi10.1038/ng.784
dc.identifier.urihttp://hdl.handle.net/2336/227800
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractWe performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
dc.language.isoenen
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://dx.doi.org/10.1038/ng.784en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119261/?tool=pubmeden_GB
dc.rightsArchived with thanks to Nature geneticsen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAllelesen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCoronary Artery Diseaseen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGene Frequencyen_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshGenome-Wide Association Studyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPolymorphism, Single Nucleotideen_GB
dc.subject.meshRisk Factorsen_GB
dc.titleLarge-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.en
dc.typeArticleen
dc.contributor.departmentUniversität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.en_GB
dc.identifier.journalNature geneticsen_GB
html.description.abstractWe performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.


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