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Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.

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Authors
Shi, Yongyong
Li, Zhiqiang
Xu, Qi
Wang, Ti
Li, Tao
Shen, Jiawei
Zhang, Fengyu
Chen, Jianhua
Zhou, Guoquan
Ji, Weidong
Li, Baojie
Xu, Yifeng
Liu, Dengtang
Wang, Peng
Yang, Ping
Liu, Benxiu
Sun, Wensheng
Wan, Chunling
Qin, Shengying
He, Guang
Steinberg, Stacy
Cichon, Sven
Werge, Thomas
Sigurdsson, Engilbert
Tosato, Sarah
Palotie, Aarno
Nöthen, Markus M
Rietschel, Marcella
Ophoff, Roel A
Collier, David A
Rujescu, Dan
Clair, David St
Stefansson, Hreinn
Stefansson, Kari
Ji, Jue
Wang, Qingzhong
Li, Wenjin
Zheng, Linqing
Zhang, Hairong
Feng, Guoyin
He, Lin
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Issue Date
2011-12

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Citation
Nat. Genet. 2011, 43(12):1224-7
Abstract
Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.
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http://dx.doi.org/10.1038/ng.980
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Archived with thanks to Nature genetics
ae974a485f413a2113503eed53cd6c53
10.1038/ng.980
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English Journal Articles (Peer Reviewed)

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