The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Sigurdardottir, Sigrun LThorleifsdottir, Ragna H
Guzman, Andrew M
Gudmundsson, Gudmundur H
Valdimarsson, Helgi
Johnston, Andrew
Issue Date
2012-02
Metadata
Show full item recordCitation
Clin. Immunol. 2012, 142(2):139-49Abstract
Antimicrobial peptides are essential elements of epithelial defense against invading micro-organisms. The palatine tonsils are positioned at the entry of the airway and the gut and as such are ideally situated to act as immune sentinels in the pharynx protecting against microbial invasion. Tonsils express a number of antimicrobial peptides including hCAP18/LL-37. Here we clearly define the expression of hCAP18/LL-37 in the tonsils showing unequivocally that hCAP18/LL-37 is mainly expressed by infiltrating neutrophils and follicular CD11c+CD13+HLA-DR+ dendritic cells, rarely by macrophages, and never by the epithelium itself. To explore possible functions for follicle-derived LL-37, we stimulated tonsil mononuclear cells with LL-37 in vitro and observed the secretion of the proinflammatory cytokines CCL5 and CXCL9, expression of IFN-γ and MX-1 and down-regulation of chemokine receptors CCR4 and CCR6 which are involved in tissue-selective T cell trafficking. Taken together, these data illustrate new potential immunoregulatory functions for hCAP18/LL-37 in the tonsils.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://dx.doi.org/10.1016/j.clim.2011.09.013Rights
Archived with thanks to Clinical immunology (Orlando, Fla.)ae974a485f413a2113503eed53cd6c53
10.1016/j.clim.2011.09.013
Scopus Count
Collections
Related articles
- Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells.
- Authors: Lowry MB, Guo C, Borregaard N, Gombart AF
- Issue date: 2014 Sep
- The host defense peptide LL-37 is detected in human parotid and submandibular/sublingual saliva and expressed in glandular neutrophils.
- Authors: Svensson D, Aidoukovitch A, Anders E, Agerberth B, Andersson F, Ekblad E, Ericson D, Nebel D, Voss U, Nilsson BO
- Issue date: 2018 Apr
- Expression and immunolocalisation of antimicrobial peptides within human palatine tonsils.
- Authors: Ball SL, Siou GP, Wilson JA, Howard A, Hirst BH, Hall J
- Issue date: 2007 Oct
- LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.
- Authors: De Yang, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O
- Issue date: 2000 Oct 2
- Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium.
- Authors: Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF
- Issue date: 2002 Feb