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Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study.

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Authors
Knevel, Rachel
Gröndal, Gerður
Huizinga, Tom W J
Visser, A Willemien
Jónsson, Helgi
Víkingsson, Arnór
Geirsson, Arni Jón
Steinsson, Kristján
van der Helm-van Mil, Annette H M
Issue Date
2012-05

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Ann. Rheum. Dis. 2012, 71(5):707-9
Abstract
The susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable. Iceland has an unique comprehensive genealogy database covering today's population and stretching back to ≥1000 years ago, as well as genome-wide single nucleotide polymorphism data for a large part of the population. Hand and feet x-rays of 325 Icelandic patients with RA were scored according to the Sharp-van der Heijde method. The degree of relatedness between patients was estimated in two ways: (1) kinship coefficients (KC) on the genealogical data were expressed; and (2) the identical-by-descent (IBD) was estimated applying long-range phasing of the genetic profile of the patients. The degree of relatedness was tested against the similarity in joint destruction rates by linear regression analysis and the heritability of joint destruction was calculated. Significant associations between degree of relatedness and similarity in joint destruction rates were observed for both methods of determining relatedness (p(KC)=0.018, p(IBD)=0.003). The estimated heritability was 45% using KC and 58% using the estimated IBD data. The severity of joint destruction in RA is influenced by genetic factors.
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http://dx.doi.org/10.1136/annrheumdis-2011-200627
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Archived with thanks to Annals of the rheumatic diseases
ae974a485f413a2113503eed53cd6c53
10.1136/annrheumdis-2011-200627
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