Obesity and the risk of psoriatic arthritis: a population-based study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsLove, Thorvardur Jon
Gelfand, Joel M
Choi, Hyon K
MetadataShow full item record
CitationAnn. Rheum. Dis. 2012, 71(8):1273-7
ÚtdrátturObesity is associated with an increased risk of psoriasis; however, its potential impact on the risk of psoriatic arthritis (PsA) remains unclear. To evaluate the association between body mass index (BMI) and the risk of PsA among patients with psoriasis from the general population. The authors conducted a cohort study using data from The Health Improvement Network, an electronic medical records database representative of the UK general population, collected between 1995 and 2010. The exposure of interest was the first BMI measured after psoriasis diagnosis and endpoints were incident cases of physician-diagnosed PsA. The authors estimated the RR of PsA after adjusting for age, sex, and histories of trauma, smoking and alcohol consumption. Among 75,395 individuals with psoriasis (43% male, mean follow-up of 5 years, and mean age of 52 years), 976 developed PsA (incidence rate, 26.5 per 10,000 person-years). The PsA incidence rates increased with increasing BMI. Compared with psoriasis patients with BMI <25 kg/m(2), the RRs for developing PsA were 1.09 (0.93-1.28) for BMIs from 25.0 to 29.9, 1.22 (1.02-1.47) for BMIs from 30.0 to 34.9 and 1.48 (1.20-1.81) for BMIs ≥35.0. In our secondary analysis among all individuals, regardless of psoriasis (~2 million), the corresponding multivariate RRs tended to be stronger (1.0, 1.17, 1.57, 1.96; p for trend <0.001). This general population study suggests that obesity is associated with an increased risk of incident PsA and supports the importance of weight reduction among psoriasis patients who often suffer from the metabolic syndrome and obesity.
Lu00FDsingTo access full text version of this article. Please click on the hyperlink "View/open" at the bottom of this page
RightsArchived with thanks to Annals of the rheumatic diseases
- Diabetes incidence in psoriatic arthritis, psoriasis and rheumatoid arthritis: a UK population-based cohort study.
- Authors: Dubreuil M, Rho YH, Man A, Zhu Y, Zhang Y, Love TJ, Ogdie A, Gelfand JM, Choi HK
- Issue date: 2014 Feb
- Obesity and risk of incident psoriatic arthritis in US women.
- Authors: Li W, Han J, Qureshi AA
- Issue date: 2012 Aug
- Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis.
- Authors: Green A, Shaddick G, Charlton R, Snowball J, Nightingale A, Smith C, Tillett W, McHugh N, PROMPT study group.
- Issue date: 2020 Mar
- Obesity in early adulthood as a risk factor for psoriatic arthritis.
- Authors: Soltani-Arabshahi R, Wong B, Feng BJ, Goldgar DE, Duffin KC, Krueger GG
- Issue date: 2010 Jul
- Differences in body mass index among individuals with PsA, psoriasis, RA and the general population.
- Authors: Bhole VM, Choi HK, Burns LC, Vera Kellet C, Lacaille DV, Gladman DD, Dutz JP
- Issue date: 2012 Mar