• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Serúlóplasmín og járn. Tengsl við Alzheimersjúkdóm og Parkinsonsjúkdóm

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
L2012-10-531-F3.pdf
Size:
269.3Kb
Format:
PDF
Download
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Þorkell Jóhannesson
Jakob Kristinsson
Guðlaug Þórsdóttir
Jón Snædal
Issue Date
2012-10

Metadata
Show full item record
Other Titles
Ceruloplasmin (Cp) and iron in connection with Parkinson's disease (PD) and Alzheimer's disease (AD)
Citation
Læknablaðið 2012, 98(10):531-7
Abstract
Ceruloplasmin, a multi-copper oxidase with four active copper atoms, oxidizes Fe2+ to Fe3+ and concomittantly fully reduces oxygen to water. The oxygenation of iron is a requisite for transferrin transport of iron and keeping noxious Fe2+ low. In the central nervous system (CNS) Cp is mostly localized in end feet of astrocytes surrounding capillaries and attached by a glycosylphosphatidylinositol-anchor. In aceruloplasminaemia, a rare recessive hereditary disease, complete loss of Cp is accompanied by disorders of iron metabolism and lesions in CNS and outside. In PD Cp concentration and oxidative activity in serum are significantly lowered with iron deposits and lesions in substantia nigra and basal ganglia. Changes in Cp-genes might be causative in these disorders. By inducing neuromelanin synthesis Cp may protect neurons in substantia nigra. In AD Cp activity in serum, but not concentration, is significantly lowered. Changes in Cp-genes have not been verified in AD. Total amounts of iron are not increased in AD brains although iron deposits and cortical lesions are numerous. Total copper is significantly lowered in AD brains. This may result in defective synthesis of Cp and other copper enzymes. - In conclusion, the defective Cp activity, associated with iron disorders, is seemingly of importance in PD and also in AD with other copper enzyme defects possibly involved.
Serúlóplasmín (Cp) er svokallaður multi-kopar oxídasi, sem in vivo oxar Fe2+ í Fe3+ og afoxar jafnframt súrefni að fullu í vatn. Cp tryggir að Fe3+ geti bundist transferríni og að magn hvarfgjarns Fe2+ haldist í lágmarki. Í miðtaugakerfinu er það einkum bundið örmum stirnufrumna með glýkósýlfosfatidýlinósítól-tengi í námunda við æðar. Í Cp eru fjögur virk koparatóm og er festing þeirra óskylt ferli myndunar próteinhluta ensímsins. Í Cp-þurrð í blóði (aserúlóplasmínemía) er alger vöntun á Cp og áberandi járnraskanir í miðtaugakerfinu og utan þess. Í Parkinsonsjúkdómi (PD) er bæði Cp-þéttni og oxunarvirkni í sermi minnkuð, samfara áberandi járnsöfnun í svartsviðið í miðheila. Cp gæti hamlað uppkomu PD með því að binda járn í neurómelaníni og varna oxunarskemmdum í orkukornum taugunga í svartsviði. Ríkur erfðaþáttur er í PD og breytingar í Cp-genum gætu tengst erfðamynstrinu. Í Alzheimersjúkdómi (AD) er oxunarvirkni Cp minnkuð í sermi, en ekki þéttni þess. Breytingar í Cp-genum virðast ekki tengjast AD. Við AD eru bæði járnraskanir og vöntun á kopar í heilanum. Koparskortur gæti valdið truflun á myndun virks Cp auk annarra koparensíma í heila. Ætla má að trufluð Cp-virkni, og þar með raskaður járnbúskapur, skipti máli við PD og við AD ásamt hugsanlega truflunum á öðrum koparensímum.
Description
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Allur texti - Full text
Additional Links
http://www.laeknabladid.is
Rights
Archived with thanks to Læknablađiđ
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: a synopsis of recent studies.
  • Authors: Kristinsson J, Snaedal J, Tórsdóttir G, Jóhannesson T
  • Issue date: 2012
  • Looking for a partner: ceruloplasmin in protein-protein interactions.
  • Authors: Vasilyev VB
  • Issue date: 2019 Apr
  • Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.
  • Authors: Zhao YS, Zhang LH, Yu PP, Gou YJ, Zhao J, You LH, Wang ZY, Zheng X, Yan LJ, Yu P, Chang YZ
  • Issue date: 2018 May 10
  • Aceruloplasminemia.
  • Authors: Kono S
  • Issue date: 2012 Aug
  • Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.
  • Authors: Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S
  • Issue date: 2002 Aug 1

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.