The advantage of mucosal immunization for polysaccharide-specific memory responses in early life
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBjarnarson, Stefania P
Del Giudice, Giuseppe
MetadataShow full item record
CitationEur. J. Immunol. 2005, 35(4):1037-45
AbstractThe aim of vaccination is to rapidly elicit protective immunity and generate memory for sustained protection. We studied the induction and persistence of polysaccharide (PS)-specific memory in neonatal and infant mice primed with pneumococcal conjugate (Pnc1-TT) by assessing the response to native pneumococcal PS (PPS-1), the kinetics of the PPS-1-specific IgG response to a second Pnc1-TT dose and affinity maturation. A subcutaneous (s.c.) Pnc1-TT booster induced a rapid increase in PPS-1-specific IgG, indicating efficient priming for memory by a single dose of Pnc1-TT already at 1 week of age. High levels were maintained for >12 weeks. However, a PPS-1 booster induced no response in neonatal or infant mice. The adjuvant LT-K63 significantly enhanced the IgG response and affinity to Pnc1-TT by both the s.c. and the intranasal (i.n.) route in all age groups. In neonatal and infant mice, PPS-1 and LT-K63 induced a booster response only when given i.n. following either s.c. or i.n. priming with Pnc1-TT and LT-K63. In contrast, PPS-1 with or without LT-K63 administered s.c. compromised the ongoing PPS-1-specific response elicited in neonatal mice by either s.c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice.
- Authors: Jakobsen H, Bjarnarson S, Del Giudice G, Moreau M, Siegrist CA, Jonsdottir I
- Issue date: 2002 Mar
- Protective levels of polysaccharide-specific maternal antibodies may enhance the immune response elicited by pneumococcal conjugates in neonatal and infant mice.
- Authors: Richter MY, Jakobsen H, Haeuw JF, Power UF, Jonsdottir I
- Issue date: 2005 Feb
- Effects of LT-K63 and CpG2006 on phenotype and function of murine neonatal lymphoid cells.
- Authors: Olafsdottir TA, Hannesdottir SG, Giudice GD, Trannoy E, Jonsdottir I
- Issue date: 2007 Oct
- Neonatal immune response and serum bactericidal activity induced by a meningococcal conjugate vaccine is enhanced by LT-K63 and CpG2006.
- Authors: Brynjolfsson SF, Bjarnarson SP, Mori E, Del Giudice G, Jonsdottir I
- Issue date: 2008 Aug 18
- The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide-specific antibody-secreting cells in neonatal mice.
- Authors: Bjarnarson SP, Adarna BC, Benonisson H, Del Giudice G, Jonsdottir I
- Issue date: 2012 Aug 1