Childhood levels of immunoglobulins and mannan-binding lectin in relation to infections and allergy
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsThorarinsdottir, H K
Ludviksson, B R
Leopoldsdottir, M O
Arason, G J
MetadataShow full item record
CitationScand. J. Immunol. 2005, 61(5):466-74
AbstractRespiratory tract infections, allergies and otitis media are common problems in early childhood. Our aim was to evaluate in a longitudinal community-based cohort study the association between maturation of immunoglobulin (Ig) and mannan-binding lectin (MBL) responses and disease manifestations in the first 4 years of life. Sustained low levels of IgA proved the strongest single indicator of susceptibility for recurrent otitis media (P = 0.008) and respiratory tract infections (P = 0.02), and this condition was also associated with low production of IgG subclasses. About 7% of the cohort had sustained low levels of MBL (<0.4 mg/l). Low MBL did not predispose to any ailments studied, but children with low IgA and recurrent otitis media had relatively low MBL at birth, which failed to increase during the study period and was significantly reduced at the age of 4 years (P = 0.04). MBL levels increased from birth to 2 years (P < 0.0001) and were higher in children than in adults (P = 0.001). The increase was 1.9-fold in children with no recorded clinical events and 1.7-fold in children with asthma or infections, but significantly lower, 1.2-fold, in children with recurrent otitis media. Low levels of IgA within the normal range may reveal disease susceptibility not detected by conventional criteria. Slow maturation of Ig appears to be the main factor of susceptibility during childhood, but a strong corollary role for MBL is indicated by the high levels produced during childhood as well as the precipitation of disease in children with low levels of MBL and Ig.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link field
- Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media.
- Authors: Wiertsema SP, Herpers BL, Veenhoven RH, Salimans MM, Ruven HJ, Sanders EA, Rijkers GT
- Issue date: 2006 Jun
- Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates.
- Authors: Swierzko AS, Atkinson AP, Cedzynski M, Macdonald SL, Szala A, Domzalska-Popadiuk I, Borkowska-Klos M, Jopek A, Szczapa J, Matsushita M, Szemraj J, Turner ML, Kilpatrick DC
- Issue date: 2009 Feb
- Genetic polymorphisms and serum levels of mannose-binding lectin in Chinese pediatric patients with common infectious diseases.
- Authors: Tao R, Hua CZ, Hu YZ, Shang SQ
- Issue date: 2012 May
- Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study.
- Authors: Lúdvíksson BR, Arason GJ, Thorarensen O, Ardal B, Valdimarsson H
- Issue date: 2005 Jan
- [Acute respiratory tract infections and mannose-binding lectin insufficiency in small children].
- Authors: Koch A, Melbye M, Sørensen P, Homøe P, Madsen HO, Mølbak K, Hansen CH, Andersen LH, Hahn GW, Garred P
- Issue date: 2002 Nov 25