• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Karason, Ari
Gudjonsson, Johann E
Jonsson, Hjortur H
Hauksson, Valdimar B
Runarsdottir, E Hjaltey
Stefansson, Kari
Valdimarsson, Helgi
Gulcher, Jeffrey R
Issue Date
2005

Metadata
Show full item record
Citation
J. Invest. Dermatol. 2005, 124(6):1177-85
Abstract
Psoriasis is a chronic inflammatory skin disease with overlapping subphenotypes. It has a strong complex genetic component, but has been problematic to identifying significant loci. We evaluated 1000 patients with chronic plaque psoriasis and documented several subphenotypes. Here we report results of genome-wide linkage scans for psoriasis genes in 238 Icelandic families with 874 patients. MHC linkage was confirmed with LOD score of 10.9. When the entire cohort was analyzed, two other loci with LOD scores of 2.5 and 1.5 were observed on 16q and 4q, respectively. Stratification into subphenotypes revealed additional loci with LOD scores exceeding or approaching significance. A LOD score of 5.7 appeared on 16q in PsA patients with analysis conditioned on parental inheritance. A LOD score of 3.6 on 4q was detected when disease occurred at or older than 17 y, our median cohort age. This locus was defined by a marker near one reportedly displaying significant linkage in a Chinese psoriasis population and near suggestive linkage in a Caucasian population. A LOD of 3.0 was observed on 10q when disease onset occurred in the scalp. Furthermore, clinical stratification either revealed or increased LOD scores when compared to unstratified analysis and some coincided with previous reports.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://www.nature.com/jid/journal/v124/n6/full/5602846a.html
ae974a485f413a2113503eed53cd6c53
10.1111/j.0022-202X.2005.23703.x
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p.
  • Authors: Burden AD, Javed S, Bailey M, Hodgins M, Connor M, Tillman D
  • Issue date: 1998 Jun
  • Evidence for a major psoriasis susceptibility locus at 6p21(PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans.
  • Authors: Zhang XJ, He PP, Wang ZX, Zhang J, Li YB, Wang HY, Wei SC, Chen SY, Xu SJ, Jin L, Yang S, Huang W
  • Issue date: 2002 Dec
  • Evidence for a novel psoriasis susceptibility locus at 9q33-9q34 in Chinese Hans.
  • Authors: Sun LD, Li W, Yang S, Fan X, Yan KL, Liang YH, Gao M, Cui Y, Xiao FL, Du WH, Zhang KY, Huang W, Liu JJ, Zhang XJ
  • Issue date: 2007 May
  • A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting.
  • Authors: Karason A, Gudjonsson JE, Upmanyu R, Antonsdottir AA, Hauksson VB, Runasdottir EH, Jonsson HH, Gudbjartsson DF, Frigge ML, Kong A, Stefansson K, Valdimarsson H, Gulcher JR
  • Issue date: 2003 Jan
  • Evidence that a locus for familial psoriasis maps to chromosome 4q.
  • Authors: Matthews D, Fry L, Powles A, Weber J, McCarthy M, Fisher E, Davies K, Williamson R
  • Issue date: 1996 Oct

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.