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Authors
Hemminki, KScélo, G
Boffetta, P
Mellemkjaer, L
Tracey, E
Andersen, A
Brewster, D H
Pukkala, E
McBride, M
Kliewer, E V
Chia, K-S
Pompe-Kirn, V
Martos, C
Jonasson, J G
Li, X
Brennan, P
Issue Date
2005-04-11
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Br. J. Cancer 2005, 92(7):1288-92Abstract
An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Link fieldAdditional Links
http://dx.doi.org/10.1038/sj.bjc.6602505ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6602505
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