Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2008-05-01
Metadata
Show full item recordCitation
Paediatr Anaesth. 2008, 18(5):435-8Abstract
We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta. Labetalol, both alpha and beta adrenergic blocking agent was used for treating postoperative hypertension. By mistake, the patient was given an extremely high dose of labetalol intravenously (17.2 mg.kg(-1)). Remarkably, the medication error had a surprisingly limited clinical effect on the infant who survived the incident. We discuss the pharmacokinetic, pharmocodynamic and possible explanations for this fortunate turn of events.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldae974a485f413a2113503eed53cd6c53
10.1111/j.1460-9592.2008.02501.x
Scopus Count
Collections
Related articles
- Severe hypertension in pregnancy: hydralazine or labetalol. A randomized clinical trial.
- Authors: Vigil-De Gracia P, Lasso M, Ruiz E, Vega-Malek JC, de Mena FT, López JC, or the HYLA treatment study.
- Issue date: 2006 Sep-Oct
- Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta.
- Authors: Bojar RM, Weiner B, Cleveland RJ
- Issue date: 1988 Sep
- Labetalol and esmolol in the control of hypertension after intracranial surgery.
- Authors: Muzzi DA, Black S, Losasso TJ, Cucchiara RF
- Issue date: 1990 Jan
- The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial.
- Authors: Tabbutt S, Nicolson SC, Adamson PC, Zhang X, Hoffman ML, Wells W, Backer CL, McGowan FX, Tweddell JS, Bokesch P, Schreiner M
- Issue date: 2008 Aug
- Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small children.
- Authors: Thomas CA, Moffett BS, Wagner JL, Mott AR, Feig DI
- Issue date: 2011 Jan