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dc.contributor.authorThjodleifsson, B
dc.contributor.authorOlafsson, I
dc.contributor.authorGislason, D
dc.contributor.authorGislason, T
dc.contributor.authorJögi, R
dc.contributor.authorJanson, C
dc.date.accessioned2008-06-04T09:42:04Z
dc.date.available2008-06-04T09:42:04Z
dc.date.issued2008-05-01
dc.date.submitted2008-06-04
dc.identifier.citationScand J Infect Dis. 2008, 40(5):381-86en
dc.identifier.issn0036-5548
dc.identifier.pmid17943636
dc.identifier.doi10.1080/00365540701708293
dc.identifier.urihttp://hdl.handle.net/2336/29457
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractViral infections have been associated with the aetiology of obesity in animal models. This study investigates the association between 7 serological markers of infections and body mass index (BMI) in a population based sample. Individuals (n=985, mean age 42+/-7 (28-55) y, mean BMI 25.5+/-4.2) from Iceland, Sweden and Estonia underwent a structured interview and blood sampling. IgG antibodies were measured against Helicobacter pylori and the cagA protein, hepatitis A virus, Toxoplasma gondii, herpes simplex virus 1, Chlamydia pneumoniae, Epstein-Barr virus and cytomegalovirus. High-sensitive C-reactive protein (CRP) was measured as a marker of systemic inflammation. A significant positive association between being overweight (BMI>25 kg/m(2)) and IgG antibodies was found for Helicobacter pylori (OR 1.86, CI 1.34-2.60) and Chlamydia pneumoniae (OR 1.39, CI 1.03-1.88) and combined seropositivity had synergistic effect (OR 2.54 (1.62-3.97)). CRP was positively related to BMI (p<0.0001), whereas no significant association was found between CRP and IgG antibodies against Helicobacter pylori and/or Chlamydia pneumoniae and CRP. The results suggest that infections with Chlamydia pneumoniae and Helicobacter pylori are both significantly and synergistically associated with overweight and this association is not related to indicators of systemic inflammation.
dc.languageENG
dc.language.ison/aen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.informaworld.com/10.1080/00365540701708293en
dc.titleInfections and obesity: A multinational epidemiological studyn/a
dc.typeArticleen
dc.contributor.departmentFrom the Medical Department, Landspitali University Hospital, Iceland.en
dc.identifier.journalScandinavian journal of infectious diseasesen
html.description.abstractViral infections have been associated with the aetiology of obesity in animal models. This study investigates the association between 7 serological markers of infections and body mass index (BMI) in a population based sample. Individuals (n=985, mean age 42+/-7 (28-55) y, mean BMI 25.5+/-4.2) from Iceland, Sweden and Estonia underwent a structured interview and blood sampling. IgG antibodies were measured against Helicobacter pylori and the cagA protein, hepatitis A virus, Toxoplasma gondii, herpes simplex virus 1, Chlamydia pneumoniae, Epstein-Barr virus and cytomegalovirus. High-sensitive C-reactive protein (CRP) was measured as a marker of systemic inflammation. A significant positive association between being overweight (BMI>25 kg/m(2)) and IgG antibodies was found for Helicobacter pylori (OR 1.86, CI 1.34-2.60) and Chlamydia pneumoniae (OR 1.39, CI 1.03-1.88) and combined seropositivity had synergistic effect (OR 2.54 (1.62-3.97)). CRP was positively related to BMI (p<0.0001), whereas no significant association was found between CRP and IgG antibodies against Helicobacter pylori and/or Chlamydia pneumoniae and CRP. The results suggest that infections with Chlamydia pneumoniae and Helicobacter pylori are both significantly and synergistically associated with overweight and this association is not related to indicators of systemic inflammation.


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