Show simple item record

dc.contributor.authorBaldursdottir, Theodora R
dc.contributor.authorBergmann, Ottar M
dc.contributor.authorJonasson, Jon G
dc.contributor.authorLudviksson, Björn R
dc.contributor.authorAxelsson, Tomas A
dc.contributor.authorBjörnsson, Einar S
dc.date.accessioned2013-07-02T14:23:49Z
dc.date.available2013-07-02T14:23:49Z
dc.date.issued2012-07
dc.date.submitted2013-07-02
dc.identifier.citationEur J Gastroenterol Hepatol 2012, 24(7):824-30en_GB
dc.identifier.issn1473-5687
dc.identifier.pmid22562114
dc.identifier.doi10.1097/MEG.0b013e328353753d
dc.identifier.urihttp://hdl.handle.net/2336/295051
dc.description.abstractVery few population-based studies exist on the epidemiology of primary biliary cirrhosis (PBC), and none have been conducted in the last decade. We aimed to determine the epidemiology and prognosis of PBC over the past two decades. Patients were identified by multiple case finding strategies, covering the total population of Iceland. A search was conducted in the centralized database of antimitochondrial antibody (AMA) measurements and computerized diagnosis and pathological registries. All AMA measurements taken in Iceland between 1991 and 2010 were analyzed. Relevant clinical information was gathered from medical records, pathology reports, and death certificates. Incidence was compared between two periods, 1991-2000 versus 2001-2010. A total of 168 patients were identified, of which 138 were female (82%), with a median age 62 years (range 13-92). Prevalence at the end of the study period was 38.3 cases per 100 000 person-years. Age-standardized incidence for female patients during the first period was 3.4 versus 4.1 during the second (NS) and that for male patients was 0.6 during the first period versus 1.0 per 100 000 during the second (NS). Overall incidence in the first period was 2.0 and that in the second was 2.5 per 100 000 (NS). Stage III-IV liver fibrosis was present in 28% of patients at diagnosis with no significant differences between the two decades. Median survival after diagnosis was 15 years. Five patients underwent liver transplantation. The incidence and prevalence figures of PBC in Iceland are among the highest reported and have been stable over the last two decades. The prognosis of patients in this population-based cohort is better than that previously reported.
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1097/MEG.0b013e328353753den_GB
dc.rightsArchived with thanks to European journal of gastroenterology & hepatologyen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Distributionen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshCholagogues and Cholereticsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshIncidenceen_GB
dc.subject.meshLiver Cirrhosis, Biliaryen_GB
dc.subject.meshLiver Transplantationen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshPrognosisen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshSeverity of Illness Indexen_GB
dc.subject.meshUrsodeoxycholic Aciden_GB
dc.subject.meshYoung Adulten_GB
dc.titleThe epidemiology and natural history of primary biliary cirrhosis: a nationwide population-based study.en
dc.typeArticleen
dc.contributor.departmentDepartment of aGastroenterology and Hepatology, Landspitali The National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland.en_GB
dc.identifier.journalEuropean journal of gastroenterology & hepatologyen_GB
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractVery few population-based studies exist on the epidemiology of primary biliary cirrhosis (PBC), and none have been conducted in the last decade. We aimed to determine the epidemiology and prognosis of PBC over the past two decades. Patients were identified by multiple case finding strategies, covering the total population of Iceland. A search was conducted in the centralized database of antimitochondrial antibody (AMA) measurements and computerized diagnosis and pathological registries. All AMA measurements taken in Iceland between 1991 and 2010 were analyzed. Relevant clinical information was gathered from medical records, pathology reports, and death certificates. Incidence was compared between two periods, 1991-2000 versus 2001-2010. A total of 168 patients were identified, of which 138 were female (82%), with a median age 62 years (range 13-92). Prevalence at the end of the study period was 38.3 cases per 100 000 person-years. Age-standardized incidence for female patients during the first period was 3.4 versus 4.1 during the second (NS) and that for male patients was 0.6 during the first period versus 1.0 per 100 000 during the second (NS). Overall incidence in the first period was 2.0 and that in the second was 2.5 per 100 000 (NS). Stage III-IV liver fibrosis was present in 28% of patients at diagnosis with no significant differences between the two decades. Median survival after diagnosis was 15 years. Five patients underwent liver transplantation. The incidence and prevalence figures of PBC in Iceland are among the highest reported and have been stable over the last two decades. The prognosis of patients in this population-based cohort is better than that previously reported.


This item appears in the following Collection(s)

Show simple item record