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dc.contributor.authorBenito de Valle, Maria
dc.contributor.authorRahman, Monira
dc.contributor.authorLindkvist, Björn
dc.contributor.authorBjörnsson, Einar
dc.contributor.authorChapman, Roger
dc.contributor.authorKalaitzakis, Evangelos
dc.date.accessioned2013-07-04T11:45:35Z
dc.date.available2013-07-04T11:45:35Z
dc.date.issued2012-07
dc.date.submitted2013-07-04
dc.identifier.citationClin Gastroenterol Hepatol 2012, 10(7):769-775.e2en_GB
dc.identifier.issn1542-7714
dc.identifier.pmid22343690
dc.identifier.doi10.1016/j.cgh.2012.01.025
dc.identifier.urihttp://hdl.handle.net/2336/295198
dc.description.abstractHealth-related quality of life (HRQL) is frequently reduced in patients with chronic liver disease, but there are limited data from patients with primary sclerosing cholangitis (PSC). We aimed to evaluate HRQL and its potential determinants in 2 population-based cohorts of patients with PSC and to study the prevalence of fatigue among these patients. Validated questionnaires were used to measure quality of life (the Short-Form 36 [SF-36] and the chronic liver disease questionnaire), fatigue (the fatigue impact scale), and psychological distress (the hospital anxiety and depression scale) in 182 PSC patients residing in Sweden or England. Results were compared with those from the general population (controls). Regression analysis was performed to identify factors independently associated with HRQL. Patients with PSC had significantly lower scores from several areas of the SF-36, compared with controls (P < .05). Age (β = -0.62 to -0.21, P < .05) and systemic symptoms (β = 3.84-15.94, P < .05) such as pruritus were associated with lower scores from specific areas of the SF-36; serum level of alkaline phosphatase (β =-1.12 to -0.75, P < .05), and large-duct PSC (β = -15.35 to -10.05, P < .05) were associated with lower scores on mental health questionnaires. The proportion of patients with significant fatigue, depression, or anxiety did not differ between patients and controls (P > .05). Quality of life is impaired in unselected patients with PSC. Fatigue does not seem to be a specific symptom of PSC. Older age, large-duct disease, and systemic symptoms seem to reduce HRQL in patients with PSC.
dc.description.sponsorshipMedical Research Council of Vastra Gotaland in Sweden ALF-22101en_GB
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1016/j.cgh.2012.01.025en_GB
dc.rightsArchived with thanks to Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Associationen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCholangitis, Sclerosingen_GB
dc.subject.meshDepressionen_GB
dc.subject.meshEnglanden_GB
dc.subject.meshFatigueen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshQuality of Lifeen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshSwedenen_GB
dc.subject.meshYoung Adulten_GB
dc.titleFactors that reduce health-related quality of life in patients with primary sclerosing cholangitis.en
dc.typeArticleen
dc.contributor.departmentInstitute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.en_GB
dc.identifier.journalClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Associationen_GB
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractHealth-related quality of life (HRQL) is frequently reduced in patients with chronic liver disease, but there are limited data from patients with primary sclerosing cholangitis (PSC). We aimed to evaluate HRQL and its potential determinants in 2 population-based cohorts of patients with PSC and to study the prevalence of fatigue among these patients. Validated questionnaires were used to measure quality of life (the Short-Form 36 [SF-36] and the chronic liver disease questionnaire), fatigue (the fatigue impact scale), and psychological distress (the hospital anxiety and depression scale) in 182 PSC patients residing in Sweden or England. Results were compared with those from the general population (controls). Regression analysis was performed to identify factors independently associated with HRQL. Patients with PSC had significantly lower scores from several areas of the SF-36, compared with controls (P < .05). Age (β = -0.62 to -0.21, P < .05) and systemic symptoms (β = 3.84-15.94, P < .05) such as pruritus were associated with lower scores from specific areas of the SF-36; serum level of alkaline phosphatase (β =-1.12 to -0.75, P < .05), and large-duct PSC (β = -15.35 to -10.05, P < .05) were associated with lower scores on mental health questionnaires. The proportion of patients with significant fatigue, depression, or anxiety did not differ between patients and controls (P > .05). Quality of life is impaired in unselected patients with PSC. Fatigue does not seem to be a specific symptom of PSC. Older age, large-duct disease, and systemic symptoms seem to reduce HRQL in patients with PSC.


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