The prevalence of chronic obstructive pulmonary disease in Uppsala, Sweden--the Burden of Obstructive Lung Disease (BOLD) study: cross-sectional population-based study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Ólafsdóttir, Inga Sif
MetadataShow full item record
CitationClin Respir J 2012, 6(2):120-7
AbstractTo estimate chronic obstructive pulmonary disease (COPD) prevalence in Uppsala and the impact of risk factors on disease prevalence using the standardised methods of the Burden of Obstructive Lung Disease (BOLD) study initiative. Randomly selected participants, aged 40 years or more (n = 548) responded to a questionnaire regarding smoking habits, respiratory symptoms, medical history, and exposure to airway irritants. Spirometry, with a post-bronchodilator test, was performed and COPD defined as post-bronchodilatory forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) < 0.70 or FEV(1)/FVC < lower limit of normality (LLN). Circulatory inflammatory markers were measured. COPD prevalence was 16.2%, which was the fourth lowest prevalence of COPD, compared with 12 other BOLD centres. Main risk factors for COPD were increasing age [odds ratio (OR) = 2.08 per 10 years] and smoking (OR = 1.33 per 10 pack years). Higher education was protective (OR = 0.70 per 5 years). Previous tuberculosis was an almost significant risk factor for COPD (P = 0.08). Subjects with COPD reported more respiratory symptoms but only 29% had previous doctor diagnosed COPD, asthma, chronic bronchitis or emphysema. Participants with COPD had higher levels of C-reactive protein (P = 0.01), but no difference was observed in interleukin 6 (IL-6) levels. Using LLN instead of the fixed FEV(1) /FVC ratio reduced the prevalence of COPD to 10%. COPD prevalence in Uppsala was similar to other BOLD centres in high-income countries. Apart from known COPD risk factors (age, smoking, lower educational level), a history of tuberculosis may be associated with COPD even in high-income countries. COPD remains under-diagnosed, as only 29% of subjects with COPD had a previously diagnosed lung disorder.
RightsArchived with thanks to The clinical respiratory journal
- The prevalence of chronic obstructive pulmonary disease in Maastricht, the Netherlands.
- Authors: Vanfleteren LE, Franssen FM, Wesseling G, Wouters EF
- Issue date: 2012 Jun
- Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey.
- Authors: Zhong N, Wang C, Yao W, Chen P, Kang J, Huang S, Chen B, Wang C, Ni D, Zhou Y, Liu S, Wang X, Wang D, Lu J, Zheng J, Ran P
- Issue date: 2007 Oct 15
- Comparison of the prevalence of chronic obstructive pulmonary disease diagnosed by lower limit of normal and fixed ratio criteria.
- Authors: Hwang YI, Kim CH, Kang HR, Shin T, Park SM, Jang SH, Park YB, Kim CH, Kim DG, Lee MG, Hyun IG, Jung KS
- Issue date: 2009 Aug
- Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study.
- Authors: Toelle BG, Xuan W, Bird TE, Abramson MJ, Atkinson DN, Burton DL, James AL, Jenkins CR, Johns DP, Maguire GP, Musk AW, Walters EH, Wood-Baker R, Hunter ML, Graham BJ, Southwell PJ, Vollmer WM, Buist AS, Marks GB
- Issue date: 2013 Feb 18
- Worldwide burden of COPD in high- and low-income countries. Part I. The burden of obstructive lung disease (BOLD) initiative.
- Authors: Buist AS, Vollmer WM, McBurnie MA
- Issue date: 2008 Jul