Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsEmilsson, Ossur Ingi
MetadataShow full item record
CitationRespir Med 2012, 106(3):459-66
AbstractNocturnal gastroesophageal reflux (nGER) has received increasing interest as a predisposing factor for respiratory diseases and sleep disturbances. The possible role of obstructive sleep apnea (OSA) contributing to nGER is of special interest. The aim of this study was to explore the association between nGER and respiratory diseases, lung function and symptoms of OSA. Participants in the Burden of Obstructive Lung Disease (BOLD) initiative in Iceland and Sweden, a random sample from the general population of 1325 adults aged 40+ (>70% response rate), were compared by pre- and post-bronchodilator spirometry, answers to questionnaires about OSA and respiratory symptoms, health, and symptoms of GER. Altogether 102 (7.7%) reported nGER and 249 had used medication against GER. The participants were divided into three groups: 1) No nGER (n = 1040), 2) treated GER without nGER (n = 183) and 3) nGER (n = 102). The nGER group had a significantly higher prevalence of respiratory and OSA symptoms than subjects without nGER. The nGER group also had a higher prevalence of COPD (GOLD stage 1+), (25.0% vs. 15.6%) (p = 0.02) and lower FEV(1)/FVC ratio (95.9% vs. 98.9% of the predicted, p = 0.01). These associations remained significant after adjusting for smoking, weight and other possible confounders. No independent association was found between having treated GER and lung function, respiratory or OSA symptoms. In our cross-sectional epidemiological study, untreated nGER is strongly associated with both respiratory and OSA symptoms as well as airflow obstruction.
RightsArchived with thanks to Respiratory medicine
- Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure.
- Authors: Green BT, Broughton WA, O'Connor JB
- Issue date: 2003 Jan 13
- Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea.
- Authors: Shepherd KL, James AL, Musk AW, Hunter ML, Hillman DR, Eastwood PR
- Issue date: 2011 Mar
- Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux.
- Authors: Emilsson ÖI, Benediktsdóttir B, Ólafsson Í, Cook E, Júlíusson S, Björnsson ES, Guðlaugsdóttir S, Guðmundsdóttir AS, Mirgorodskaya E, Ljungström E, Arnardóttir ES, Gíslason T, Janson C, Olin AC
- Issue date: 2016 Sep 20
- The prevalence of chronic obstructive pulmonary disease in Uppsala, Sweden--the Burden of Obstructive Lung Disease (BOLD) study: cross-sectional population-based study.
- Authors: Danielsson P, Ólafsdóttir IS, Benediktsdóttir B, Gíslason T, Janson C
- Issue date: 2012 Apr
- Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea.
- Authors: Tamanna S, Campbell D, Warren R, Ullah MI
- Issue date: 2016 Sep 15