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dc.contributor.authorGeirsdottir, Asbjorg
dc.contributor.authorPalsson, Olafur
dc.contributor.authorHardarson, Sveinn Hakon
dc.contributor.authorOlafsdottir, Olof Birna
dc.contributor.authorKristjansdottir, Jona Valgerdur
dc.contributor.authorStefánsson, Einar
dc.date.accessioned2013-08-15T15:23:48Z
dc.date.available2013-08-15T15:23:48Z
dc.date.issued2012
dc.date.submitted2013-08-15
dc.identifier.citationInvest. Ophthalmol. Vis. Sci. 2012, 53(9):5433-42en_GB
dc.identifier.issn1552-5783
dc.identifier.pmid22786895
dc.identifier.doi10.1167/iovs.12-9912
dc.identifier.urihttp://hdl.handle.net/2336/298896
dc.description.abstractWe measured oxygen saturation in retinal vessels of healthy eyes to determine the effects of age, sex, and cardiovascular parameters, as well as the reliability of the measurements and topographic differences. The Oxymap T1 retinal oximeter is based on a fundus camera. It simultaneously captures retinal images at two different wavelengths and estimates retinal vessel oxygen saturation. Mean saturation of main retinal arterioles and venules was measured in 120 healthy individuals aged 18-80 years (median 47 years). Of the 120 participants 44 (37%) were male (49 years) and 76 (63%) female (44 years). Oxygen saturation was 92.2 ± 3.7% (mean ± SD) in retinal arterioles and 55.6 ± 6.3% in venules. No significant difference in oxygen saturation was found between left and right eyes. The inferotemporal quadrant had lower oxygen saturation in arterioles and venules (P < 0.0001). Arteriolar oxygen saturation was stable with age. Venular oxygen saturation in males decreased by 1.9 ± 0.6% (mean ± SEM) per 10 years of age (P = 0.003) and by 0.7 ± 0.4% in females (P = 0.068). Arteriovenous (AV) difference increased by 1.5 ± 0.5% per 10 years in males (P = 0.004) and 1.0 ± 0.4% (P = 0.007) in females. For every 10 mm Hg increase in ocular perfusion pressure, oxygen saturation in arterioles increased by 0.9 ± 0.4% (P = 0.024) and in venules by 1.2 ± 0.7% (P = 0.075). Retinal arteriolar oxygen saturation is stable in healthy individuals, while there is a significant decrease in venular oxygen saturation with age in males and a similar trend in females. AV difference increases significantly with age for both sexes. Our study provided normative data for spectrophotometric retinal oximetry in the Caucasian population.
dc.description.sponsorshipPrevention of Blindness Fund Landspitali-University Hospital Research Fund University of Iceland Research Fund Icelandic Center for Research (Rannis) Funden_GB
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1167/iovs.12-9912en_GB
dc.relation.urlhttp://www.iovs.org/content/53/9/5433.longen_GB
dc.rightsArchived with thanks to Investigative ophthalmology & visual scienceen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAgingen_GB
dc.subject.meshArteriolesen_GB
dc.subject.meshBlood Pressureen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFluorescein Angiographyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOximetryen_GB
dc.subject.meshOxygenen_GB
dc.subject.meshRetinal Arteryen_GB
dc.subject.meshRetinal Veinen_GB
dc.subject.meshSex Characteristicsen_GB
dc.subject.meshVenulesen_GB
dc.subject.meshYoung Adulten_GB
dc.titleRetinal vessel oxygen saturation in healthy individuals.en
dc.typeArticleen
dc.contributor.departmentUniversity of Iceland, Reykjavik, Iceland.en_GB
dc.identifier.journalInvestigative ophthalmology & visual scienceen_GB
dc.rights.accessOpen Access - Opinn aðganguren
html.description.abstractWe measured oxygen saturation in retinal vessels of healthy eyes to determine the effects of age, sex, and cardiovascular parameters, as well as the reliability of the measurements and topographic differences. The Oxymap T1 retinal oximeter is based on a fundus camera. It simultaneously captures retinal images at two different wavelengths and estimates retinal vessel oxygen saturation. Mean saturation of main retinal arterioles and venules was measured in 120 healthy individuals aged 18-80 years (median 47 years). Of the 120 participants 44 (37%) were male (49 years) and 76 (63%) female (44 years). Oxygen saturation was 92.2 ± 3.7% (mean ± SD) in retinal arterioles and 55.6 ± 6.3% in venules. No significant difference in oxygen saturation was found between left and right eyes. The inferotemporal quadrant had lower oxygen saturation in arterioles and venules (P < 0.0001). Arteriolar oxygen saturation was stable with age. Venular oxygen saturation in males decreased by 1.9 ± 0.6% (mean ± SEM) per 10 years of age (P = 0.003) and by 0.7 ± 0.4% in females (P = 0.068). Arteriovenous (AV) difference increased by 1.5 ± 0.5% per 10 years in males (P = 0.004) and 1.0 ± 0.4% (P = 0.007) in females. For every 10 mm Hg increase in ocular perfusion pressure, oxygen saturation in arterioles increased by 0.9 ± 0.4% (P = 0.024) and in venules by 1.2 ± 0.7% (P = 0.075). Retinal arteriolar oxygen saturation is stable in healthy individuals, while there is a significant decrease in venular oxygen saturation with age in males and a similar trend in females. AV difference increases significantly with age for both sexes. Our study provided normative data for spectrophotometric retinal oximetry in the Caucasian population.


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