High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.
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Authors
Ferreira, Ricardo CPan-Hammarström, Qiang
Graham, Robert R
Fontán, Gumersindo
Lee, Annette T
Ortmann, Ward
Wang, Ning
Urcelay, Elena
Fernández-Arquero, Miguel
Núñez, Concepción
Jorgensen, Gudmundur
Ludviksson, Björn R
Koskinen, Sinikka
Haimila, Katri
Padyukov, Leonid
Gregersen, Peter K
Hammarström, Lennart
Behrens, Timothy W
Issue Date
2012-01
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PLoS Genet. 2012, 8(1):e1002476Abstract
Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry. The polygenic nature of IgAD is underscored by the recent identification of several new risk genes in a genome-wide association study. Among the characterized susceptibility loci, the association with specific HLA haplotypes represents the major genetic risk factor for IgAD. Despite the robust association, the nature and location of the causal variants in the HLA region remains unknown. To better characterize the association signal in this region, we performed a high-density SNP mapping of the HLA locus and imputed the genotypes of common HLA-B, -DRB1, and -DQB1 alleles in a combined sample of 772 IgAD patients and 1,976 matched controls from 3 independent European populations. We confirmed the complex nature of the association with the HLA locus, which is the result of multiple effects spanning the entire HLA region. The primary association signal mapped to the HLA-DQB1*02 allele in the HLA Class II region (combined P = 7.69×10(-57); OR = 2.80) resulting from the combined independent effects of the HLA-B*0801-DRB1*0301-DQB1*02 and -DRB1*0701-DQB1*02 haplotypes, while additional secondary signals were associated with the DRB1*0102 (combined P = 5.86×10(-17); OR = 4.28) and the DRB1*1501 (combined P = 2.24×10(-35); OR = 0.13) alleles. Despite the strong population-specific frequencies of HLA alleles, we found a remarkable conservation of these effects regardless of the ethnic background, which supports the use of large multi-ethnic populations to characterize shared genetic association signals in the HLA region. We also provide evidence for the location of association signals within the specific extended haplotypes, which will guide future sequencing studies aimed at characterizing the precise functional variants contributing to disease pathogenesis.Additional Links
http://dx.doi.org/10.1371/journal.pgen.1002476http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002476
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266887/pdf/pgen.1002476.pdf
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Archived with thanks to PLoS geneticsae974a485f413a2113503eed53cd6c53
10.1371/journal.pgen.1002476
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