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dc.contributor.authorGudmundsson, Julius
dc.contributor.authorSulem, Patrick
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorJonasson, Jon G
dc.contributor.authorMasson, Gisli
dc.contributor.authorHe, Huiling
dc.contributor.authorJonasdottir, Aslaug
dc.contributor.authorSigurdsson, Asgeir
dc.contributor.authorStacey, Simon N
dc.contributor.authorJohannsdottir, Hrefna
dc.contributor.authorHelgadottir, Hafdis Th
dc.contributor.authorLi, Wei
dc.contributor.authorNagy, Rebecca
dc.contributor.authorRingel, Matthew D
dc.contributor.authorKloos, Richard T
dc.contributor.authorde Visser, Marieke C H
dc.contributor.authorPlantinga, Theo S
dc.contributor.authorden Heijer, Martin
dc.contributor.authorAguillo, Esperanza
dc.contributor.authorPanadero, Angeles
dc.contributor.authorPrats, Enrique
dc.contributor.authorGarcia-Castaño, Almudena
dc.contributor.authorDe Juan, Ana
dc.contributor.authorRivera, Fernando
dc.contributor.authorWalters, G Bragi
dc.contributor.authorBjarnason, Hjordis
dc.contributor.authorTryggvadottir, Laufey
dc.contributor.authorEyjolfsson, Gudmundur I
dc.contributor.authorBjornsdottir, Unnur S
dc.contributor.authorHolm, Hilma
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorKristjansson, Kristleifur
dc.contributor.authorKristvinsson, Hoskuldur
dc.contributor.authorMagnusson, Olafur T
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorGulcher, Jeffrey R
dc.contributor.authorKong, Augustine
dc.contributor.authorKiemeney, Lambertus A L M
dc.contributor.authorJonsson, Thorvaldur
dc.contributor.authorHjartarson, Hannes
dc.contributor.authorMayordomo, Jose I
dc.contributor.authorNetea-Maier, Romana T
dc.contributor.authorde la Chapelle, Albert
dc.contributor.authorHrafnkelsson, Jon
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorRafnar, Thorunn
dc.contributor.authorStefansson, Kari
dc.date.accessioned2013-08-19T15:16:37Z
dc.date.available2013-08-19T15:16:37Z
dc.date.issued2012-03
dc.date.submitted2013-08-19
dc.identifier.citationNat. Genet. 2012, 44(3):319-22en_GB
dc.identifier.issn1546-1718
dc.identifier.pmid22267200
dc.identifier.doi10.1038/ng.1046
dc.identifier.urihttp://hdl.handle.net/2336/299088
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractTo search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood.
dc.description.sponsorshipUS National Institutes of Health CA16058 CA124570en_GB
dc.language.isoenen
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655412/en_GB
dc.relation.urlhttp://dx.doi.org/10.1038/ng.1046en_GB
dc.rightsArchived with thanks to Nature geneticsen_GB
dc.subject.meshChromosomes, Human, Pair 14en_GB
dc.subject.meshChromosomes, Human, Pair 2en_GB
dc.subject.meshChromosomes, Human, Pair 8en_GB
dc.subject.meshGenetic Locien_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshGenetic Variationen_GB
dc.subject.meshGenome-Wide Association Studyen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshNeuregulin-1en_GB
dc.subject.meshPolymorphism, Single Nucleotideen_GB
dc.subject.meshThyroid Neoplasmsen_GB
dc.subject.meshThyrotropinen_GB
dc.titleDiscovery of common variants associated with low TSH levels and thyroid cancer risk.en
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland.en_GB
dc.identifier.journalNature geneticsen_GB
dc.rights.accessOpen Access - Opinn aðganguren
html.description.abstractTo search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood.


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