Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationRespiration 2012, 84(1):80-6
AbstractMiddle lobe syndrome (MLS) is a rare but important clinical entity that has been poorly defined in the literature. It is characterized by recurrent or chronic collapse of the middle lobe of the right lung but can also involve the lingula of the left lung. Pathophysiologically, there are two forms of MLS, namely obstructive and nonobstructive. Obstructive MLS is usually caused by endobronchial lesions or extrinsic compression of the middle lobe bronchus such as from hilar lymphadenopathy or tumors of neoplastic origin, resulting in postobstructive atelectasis and pneumonitis. In the nonobstructive type, no obstruction of the middle lobe bronchus is evident during bronchoscopy or with computerized tomography of the chest. The etiology of the nonobstructive form is not completely understood. Inefficient collateral ventilation, infection and inflammation in the middle lobe or lingula are thought to play a role, and bronchiectasis is the most common histological finding. Patients with proven endobronchial lesions or malignancy are usually offered surgical resection directly. This contrasts with nonobstructive MLS, where most patients respond to medical treatment consisting of bronchodilators, mucolytics and broad-spectrum antibiotics. However, some patients do not respond to conservative treatment and may suffer irreversible damage of the middle lobe or lingula, in addition to having recurrent symptoms of infection or inflammation. These selected patients can be offered surgical resection of the middle lobe or lingula, which is associated with a low mortality rate and favorable outcome.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to Respiration; international review of thoracic diseases
- Middle lobe syndrome.
- Authors: Gudmundsson G, Gross TJ
- Issue date: 1996 Jun
- Middle lobe syndrome in children today.
- Authors: Romagnoli V, Priftis KN, de Benedictis FM
- Issue date: 2014 Jun
- [Middle lobe syndrome].
- Authors: Rollan V, Sanz N, Alvarez M, Sequeiros A, Gimeno M
- Issue date: 1994 Apr
- Middle lobe syndrome: a clinicopathological study of 21 patients.
- Authors: Kwon KY, Myers JL, Swensen SJ, Colby TV
- Issue date: 1995 Mar
- Infectious Causes of Right Middle Lobe Syndrome.
- Authors: Rashid A, Nanjappa S, Greene JN
- Issue date: 2017 Jan