Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.
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Authors
Laurberg, PAndersen, S
Bjarnadóttir, R I
Carlé, A
Hreidarsson, Ab
Knudsen, N
Ovesen, L
Pedersen, Ib
Rasmussen, Lb
Issue Date
2007-12-01
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Public Health Nutr. 2007, 10(12A):1547-52; discussion 1553Abstract
OBJECTIVE: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. DESIGN: Review of the literature regarding the various methods available for assessing iodine status.Setting: Population surveys and research studies. SUBJECTS: Pregnant women and young infants. RESULTS: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (microg l-1) is not interchangeable with 24 h UI excretion (microg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. CONCLUSIONS: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.Description
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http://dx.doi.org/10.1017/S1368980007360898ae974a485f413a2113503eed53cd6c53
10.1017/S1368980007360898
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