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dc.contributor.authorHalldórsdóttir, Anna Margrét
dc.contributor.authorFrühwirth, Margareta
dc.contributor.authorDeutsch, Alexander
dc.contributor.authorAigelsreiter, Ariane
dc.contributor.authorBeham-Schmid, Christine
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorNeumeister, Peter
dc.contributor.authorRichard Burack, W
dc.date.accessioned2008-06-13T12:02:19Z
dc.date.available2008-06-13T12:02:19Z
dc.date.issued2008-07-01
dc.date.submitted2008-06-13
dc.identifier.citationLeuk. Res. 2008, 32(7):1015-21en
dc.identifier.issn0145-2126
dc.identifier.pmid18180034
dc.identifier.doi10.1016/j.leukres.2007.11.028
dc.identifier.urihttp://hdl.handle.net/2336/30024
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSomatic hypermutation (SHM) aberrantly targets proto-oncogenes in various non-Hodgkin's lymphoma. To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology. No difference was detected in the fraction of specimens mutated (75% of lgFL and 77% of tFL) or in the mutation load (0.08 for lgFL vs. 0.06mutations/100bp/allele for tFL). Serial specimens were examined from 25 patients showing stable low-grade FL (slgFL; n=6) or a low-grade FL that later transformed into diffuse large cell lymphoma (tFL; n=19). slgFL and tFL patients accumulated similar numbers of mutations in the interval between biopsies. These data indicate that mutations attributable to aberrant SHM occur with similar frequency in low-grade and transformed FL; transformation is not associated with a higher rate of aberrant SHM. Moreover, the frequency of mutations attributable to aberrant SHM in tFL was significantly lower than that reported for de novo diffuse large B cell lymphoma, suggesting differing oncogenic mechanisms in transformed follicular lymphoma and de novo diffuse large B cell lymphoma.
dc.language.isoenen
dc.publisherPergamon Pressen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6T98-4RH8SGP-3/1/db7340823f8b94a8e8ed194aff8c22f0en
dc.subject.meshLymphoma, Follicularen
dc.subject.meshPubMed - in processen
dc.titleQuantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.en
dc.identifier.journalLeukemia researchen
html.description.abstractSomatic hypermutation (SHM) aberrantly targets proto-oncogenes in various non-Hodgkin's lymphoma. To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology. No difference was detected in the fraction of specimens mutated (75% of lgFL and 77% of tFL) or in the mutation load (0.08 for lgFL vs. 0.06mutations/100bp/allele for tFL). Serial specimens were examined from 25 patients showing stable low-grade FL (slgFL; n=6) or a low-grade FL that later transformed into diffuse large cell lymphoma (tFL; n=19). slgFL and tFL patients accumulated similar numbers of mutations in the interval between biopsies. These data indicate that mutations attributable to aberrant SHM occur with similar frequency in low-grade and transformed FL; transformation is not associated with a higher rate of aberrant SHM. Moreover, the frequency of mutations attributable to aberrant SHM in tFL was significantly lower than that reported for de novo diffuse large B cell lymphoma, suggesting differing oncogenic mechanisms in transformed follicular lymphoma and de novo diffuse large B cell lymphoma.


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