Sleep apnea and glucose metabolism: a long-term follow-up in a community-based sample.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Lindberg, EvaTheorell-Haglöw, Jenny
Svensson, Malin
Gislason, Thorarinn
Berne, Christian
Janson, Christer
Issue Date
2012-10
Metadata
Show full item recordCitation
Chest 2012, 142(4):935-42Abstract
It has been suggested that sleep-disordered breathing (SDB) is a risk factor for diabetes, but long-term follow-up studies are lacking. The aim of this community-based study was to analyze the influence of SDB on glucose metabolism after > 10 years. Men without diabetes (N = 141; mean age, 57.5 years) were investigated at baseline, including whole-night respiratory monitoring. After a mean period of 11 years and 4 months, they were followed up with an interview, anthropometric measurements, and blood sampling. Insulin resistance was quantified using the homeostasis model assessment of insulin resistance (HOMA-IR). ΔHOMA-IR was calculated as (HOMA-IR at follow-up − HOMA-IR at baseline). An oral glucose tolerance test was performed on 113 men to calculate the insulin sensitivity index. The mean apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) at baseline were 4.7 and 3.3, respectively. At follow-up, 23 men had diabetes. An ODI > 5 was a predictor of developing diabetes (OR, 4.4; 95% CI, 1.1-18.1, after adjusting for age, BMI, and hypertension at baseline and ΔBMI and years with CPAP during follow-up). The ODI was inversely related to the insulin sensitivity index at follow-up (r = −0.27, P = .003). A deterioration in HOMA-IR was significantly related to all variables of SDB (AHI, AHI > 5; ODI, ODI > 5; minimum arterial oxygen saturation), even when adjusting for confounders. When excluding the variable years with CPAP from the multivariate model, all associations weakened. SDB is independently related to the development of insulin resistance and, thereby, the risk of manifest diabetes mellitus.Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://dx.doi.org/10.1378/chest.11-1844http://journal.publications.chestnet.org/article.aspx?articleid=1215994
Rights
Archived with thanks to Chestae974a485f413a2113503eed53cd6c53
10.1378/chest.11-1844
Scopus Count
Collections
Related articles
- Sleep apnea predicts distinct alterations in glucose homeostasis and biomarkers in obese adults with normal and impaired glucose metabolism.
- Authors: Pallayova M, Steele KE, Magnuson TH, Schweitzer MA, Hill NR, Bevans-Fonti S, Schwartz AR
- Issue date: 2010 Dec 1
- Association between Glucose Metabolism and Sleep-disordered Breathing during REM Sleep.
- Authors: Chami HA, Gottlieb DJ, Redline S, Punjabi NM
- Issue date: 2015 Nov 1
- Alterations in Glucose Disposal in Sleep-disordered Breathing.
- Authors: Punjabi NM, Beamer BA
- Issue date: 2009 Feb 1
- Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea.
- Authors: Cuhadaroğlu C, Utkusavaş A, Oztürk L, Salman S, Ece T
- Issue date: 2009 Mar-Apr
- [Factors influencing glucose metabolism in young obese subjects with obstructive sleep apnea hypopnea syndrome].
- Authors: Gu CJ, Li QY, Li M, Zhou J, Du J, Yi HH, Feng J, Zhou LN, Wang Q
- Issue date: 2016 May 17