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dc.contributor.authorLieder, Ramona
dc.contributor.authorThormodsson, Finnbogi
dc.contributor.authorNg, C-H
dc.contributor.authorEinarsson, Jon M
dc.contributor.authorGislason, Johannes
dc.contributor.authorPetersen, Petur H
dc.contributor.authorSigurjonsson, Olafur E
dc.date.accessioned2013-08-30T15:21:01Z
dc.date.available2013-08-30T15:21:01Z
dc.date.issued2012-11
dc.date.submitted2013-08-30
dc.identifier.citationInt. J. Biol. Macromol. 2012, 51(4):675-80en_GB
dc.identifier.issn1879-0003
dc.identifier.pmid22790025
dc.identifier.doi10.1016/j.ijbiomac.2012.07.005
dc.identifier.urihttp://hdl.handle.net/2336/300416
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractChitooligosaccharides are of interest as potential drugs due to their bioactivity and water solubility. We compared the effect of acetylated and deacetylated chitooligomers (Hexamers) on short-term expansion (7 days) and osteogenic differentiation of bone-marrow derived, human mesenchymal stem cells in terms of gene expression, cytokine secretion and quality of osteogenic differentiation. We show that chitooligomers affect hMSC gene expression and cytokine secretion, but not mineralization. The effect of chitooligomers was shown to be dependent on the acetylation degree, with significantly stronger effects when cells are stimulated with chitin-derived Hexamers (N-Acetyl Chitohexaose) than with Chitosan Hexamers (Chitohexaose).
dc.description.sponsorshipIcelandic Centre for Research Landspitali University Hospitalen_GB
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1016/j.ijbiomac.2012.07.005en_GB
dc.rightsArchived with thanks to International journal of biological macromoleculesen_GB
dc.subject.meshAdipokinesen_GB
dc.subject.meshBiocompatible Materialsen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshBone Marrow Cellsen_GB
dc.subject.meshCalcification, Physiologicen_GB
dc.subject.meshCell Differentiationen_GB
dc.subject.meshCell Proliferationen_GB
dc.subject.meshChitosanen_GB
dc.subject.meshCytokinesen_GB
dc.subject.meshGene Expression Regulationen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLectinsen_GB
dc.subject.meshMesenchymal Stromal Cellsen_GB
dc.subject.meshOsteogenesisen_GB
dc.subject.meshPolymerizationen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshToll-Like Receptor 3en_GB
dc.titleChitosan and Chitin Hexamers affect expansion and differentiation of mesenchymal stem cells differently.en
dc.typeArticleen
dc.contributor.departmentThe Blood Bank, Landspitali University Hospital, Snorrabraut 60, 105 Reykjavik, Iceland.en_GB
dc.identifier.journalInternational journal of biological macromoleculesen_GB
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractChitooligosaccharides are of interest as potential drugs due to their bioactivity and water solubility. We compared the effect of acetylated and deacetylated chitooligomers (Hexamers) on short-term expansion (7 days) and osteogenic differentiation of bone-marrow derived, human mesenchymal stem cells in terms of gene expression, cytokine secretion and quality of osteogenic differentiation. We show that chitooligomers affect hMSC gene expression and cytokine secretion, but not mineralization. The effect of chitooligomers was shown to be dependent on the acetylation degree, with significantly stronger effects when cells are stimulated with chitin-derived Hexamers (N-Acetyl Chitohexaose) than with Chitosan Hexamers (Chitohexaose).


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