Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
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Authors
Morris, Andrew PVoight, Benjamin F
Teslovich, Tanya M
Ferreira, Teresa
Segrè, Ayellet V
Steinthorsdottir, Valgerdur
Strawbridge, Rona J
Khan, Hassan
Grallert, Harald
Mahajan, Anubha
Prokopenko, Inga
Kang, Hyun Min
Dina, Christian
Esko, Tonu
Fraser, Ross M
Kanoni, Stavroula
Kumar, Ashish
Lagou, Vasiliki
Langenberg, Claudia
Luan, Jian'an
Lindgren, Cecilia M
Müller-Nurasyid, Martina
Pechlivanis, Sonali
Rayner, N William
Scott, Laura J
Wiltshire, Steven
Yengo, Loic
Kinnunen, Leena
Rossin, Elizabeth J
Raychaudhuri, Soumya
Johnson, Andrew D
Dimas, Antigone S
Loos, Ruth J F
Vedantam, Sailaja
Chen, Han
Florez, Jose C
Fox, Caroline
Liu, Ching-Ti
Rybin, Denis
Couper, David J
Kao, Wen Hong L
Li, Man
Cornelis, Marilyn C
Kraft, Peter
Sun, Qi
van Dam, Rob M
Stringham, Heather M
Chines, Peter S
Fischer, Krista
Fontanillas, Pierre
Holmen, Oddgeir L
Hunt, Sarah E
Jackson, Anne U
Kong, Augustine
Lawrence, Robert
Meyer, Julia
Perry, John R B
Platou, Carl G P
Potter, Simon
Rehnberg, Emil
Robertson, Neil
Sivapalaratnam, Suthesh
Stančáková, Alena
Stirrups, Kathleen
Thorleifsson, Gudmar
Tikkanen, Emmi
Wood, Andrew R
Almgren, Peter
Atalay, Mustafa
Benediktsson, Rafn
Bonnycastle, Lori L
Burtt, Noël
Carey, Jason
Charpentier, Guillaume
Crenshaw, Andrew T
Doney, Alex S F
Dorkhan, Mozhgan
Edkins, Sarah
Emilsson, Valur
Eury, Elodie
Forsen, Tom
Gertow, Karl
Gigante, Bruna
Grant, George B
Groves, Christopher J
Guiducci, Candace
Herder, Christian
Hreidarsson, Astradur B
Hui, Jennie
James, Alan
Jonsson, Anna
Rathmann, Wolfgang
Klopp, Norman
Kravic, Jasmina
Krjutškov, Kaarel
Langford, Cordelia
Leander, Karin
Lindholm, Eero
Lobbens, Stéphane
Männistö, Satu
Mirza, Ghazala
Mühleisen, Thomas W
Musk, Bill
Parkin, Melissa
Rallidis, Loukianos
Saramies, Jouko
Sennblad, Bengt
Shah, Sonia
Sigurðsson, Gunnar
Silveira, Angela
Steinbach, Gerald
Thorand, Barbara
Trakalo, Joseph
Veglia, Fabrizio
Wennauer, Roman
Winckler, Wendy
Zabaneh, Delilah
Campbell, Harry
van Duijn, Cornelia
Uitterlinden, Andre G
Hofman, Albert
Sijbrands, Eric
Abecasis, Goncalo R
Owen, Katharine R
Zeggini, Eleftheria
Trip, Mieke D
Forouhi, Nita G
Syvänen, Ann-Christine
Eriksson, Johan G
Peltonen, Leena
Nöthen, Markus M
Balkau, Beverley
Palmer, Colin N A
Lyssenko, Valeriya
Tuomi, Tiinamaija
Isomaa, Bo
Hunter, David J
Qi, Lu
Shuldiner, Alan R
Roden, Michael
Barroso, Ines
Wilsgaard, Tom
Beilby, John
Hovingh, Kees
Price, Jackie F
Wilson, James F
Rauramaa, Rainer
Lakka, Timo A
Lind, Lars
Dedoussis, George
Njølstad, Inger
Pedersen, Nancy L
Khaw, Kay-Tee
Wareham, Nicholas J
Keinanen-Kiukaanniemi, Sirkka M
Saaristo, Timo E
Korpi-Hyövälti, Eeva
Saltevo, Juha
Laakso, Markku
Kuusisto, Johanna
Metspalu, Andres
Collins, Francis S
Mohlke, Karen L
Bergman, Richard N
Tuomilehto, Jaakko
Boehm, Bernhard O
Gieger, Christian
Hveem, Kristian
Cauchi, Stephane
Froguel, Philippe
Baldassarre, Damiano
Tremoli, Elena
Humphries, Steve E
Saleheen, Danish
Danesh, John
Ingelsson, Erik
Ripatti, Samuli
Salomaa, Veikko
Erbel, Raimund
Jöckel, Karl-Heinz
Moebus, Susanne
Peters, Annette
Illig, Thomas
de Faire, Ulf
Hamsten, Anders
Morris, Andrew D
Donnelly, Peter J
Frayling, Timothy M
Hattersley, Andrew T
Boerwinkle, Eric
Melander, Olle
Kathiresan, Sekar
Nilsson, Peter M
Deloukas, Panos
Thorsteinsdottir, Unnur
Groop, Leif C
Stefansson, Kari
Hu, Frank
Pankow, James S
Dupuis, Josée
Meigs, James B
Altshuler, David
Boehnke, Michael
McCarthy, Mark I
Issue Date
2012-09
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Nat. Genet. 2012, 44(9):981-90Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://dx.doi.org/10.1038/ng.2383http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442244/
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Archived with thanks to Nature geneticsae974a485f413a2113503eed53cd6c53
10.1038/ng.2383
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