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dc.contributor.authorOrmarsson, Orri Thor
dc.contributor.authorGeirsson, Thormodur
dc.contributor.authorBjornsson, Einar Stefan
dc.contributor.authorJonsson, Tomas
dc.contributor.authorMoller, Pall
dc.contributor.authorLoftsson, Thorsteinn
dc.contributor.authorStefansson, Einar
dc.date.accessioned2013-09-05T15:04:55Z
dc.date.available2013-09-05T15:04:55Z
dc.date.issued2012-09
dc.date.submitted2013-09-05
dc.identifier.citationMar Drugs 2012, 10(9):2047-54en_GB
dc.identifier.issn1660-3397
dc.identifier.pmid23118720
dc.identifier.doi10.3390/md10092047
dc.identifier.urihttp://hdl.handle.net/2336/301116
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractCod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.
dc.language.isoenen
dc.publisherMDPI AGen_GB
dc.relation.urlhttp://dx.doi.org/10.3390/md10092047en_GB
dc.relation.urlhttp://www.mdpi.com/1660-3397/10/9/2047en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475272/en_GB
dc.rightsArchived with thanks to Marine drugsen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshFatty Acids, Omega-3en_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFish Oilsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLaxativesen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOintmentsen_GB
dc.subject.meshSuppositoriesen_GB
dc.subject.meshYoung Adulten_GB
dc.titleClinical trial: marine lipid suppositories as laxatives.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatric Surgery, Children's Hospital, Landspitali-University Hospital, 101 Reykjavik, Iceland.en_GB
dc.identifier.journalMarine drugsen_GB
dc.rights.accessOpen Access - Opinn aðganguren
html.description.abstractCod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.


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