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dc.contributor.authorPalsson, Olafur
dc.contributor.authorGeirsdottir, Asbjorg
dc.contributor.authorHardarson, Sveinn Hakon
dc.contributor.authorOlafsdottir, Olof Birna
dc.contributor.authorKristjansdottir, Jona Valgerdur
dc.contributor.authorStefánsson, Einar
dc.date.accessioned2013-09-06T11:43:25Z
dc.date.available2013-09-06T11:43:25Z
dc.date.issued2012-04
dc.date.submitted2013-09-06
dc.identifier.citationInvest. Ophthalmol. Vis. Sci. 2012, 53(4):1729-33en_GB
dc.identifier.issn1552-5783
dc.identifier.pmid22395877
dc.identifier.doi10.1167/iovs.11-8621
dc.identifier.urihttp://hdl.handle.net/2336/301237
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractRetinal vessel oximetry is a new technology and needs detailed methodological scrutiny. We determine (1) the repeatability of retinal vessel oxygen saturation measurements, (2) whether measured saturation is different between retinal quadrants, and (3) whether the angle of gaze changes measurements of the same vessels. Fundus oximetry images were obtained from 26 healthy individuals, 18 to 30 years old, using the Oxymap retinal oximeter. Oxygen saturation in the same vessel segments was compared between two similar images of each individual to determine repeatability. Vessel oxygen saturation was also compared between different quadrants of the retina in the same oximetry image. Finally, oxygen saturation measurements were made on the same vessel segments at different angles of gaze. Mean and standard deviation of saturation measurements was 93.1% ± 2.3% in arterioles and 64.9% ± 3.3% in venules. Standard deviation of repeated saturation measurements on the same vessel segment was 1.0% in arterioles and 1.4% in venules. Significant differences were seen between retinal quadrants. When angle of gaze was altered, measured saturation was lower in the same vessels when they were located in the inferior portion compared with other parts of the image (-1.3% ± 1.7%, P = 0.0004 in arterioles and -1.9 ± 2.4%, P = 0.0007 in venules). Retinal vessel oxygen saturation measurements are repeatable with a small standard deviation. When oximetry results are compared between time points or eyes, the imaging must be standardized and similar parts of the images analyzed.
dc.description.sponsorshipIcelandic Center for Research (Rannis) University of Iceland Research Fund Landspitali University Hospitalen_GB
dc.language.isoenen
dc.publisherAssoc Research Vision Ophthalmologyen_GB
dc.relation.urlhttp://dx.doi.org/10.1167/iovs.11-8621en_GB
dc.relation.urlhttp://www.iovs.org/content/53/4/1729.longen_GB
dc.rightsArchived with thanks to Investigative ophthalmology & visual scienceen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshArteriolesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshOximetryen_GB
dc.subject.meshOxygenen_GB
dc.subject.meshOxygen Consumptionen_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshRetinal Vesselsen_GB
dc.subject.meshVenulesen_GB
dc.subject.meshYoung Adulten_GB
dc.titleRetinal oximetry images must be standardized: a methodological analysis.en
dc.typeArticleen
dc.contributor.departmentUniversity of Iceland, National University Hospital, Reykjavik, Iceland.en_GB
dc.identifier.journalInvestigative ophthalmology & visual scienceen_GB
dc.rights.accessOpen Access - Opinn aðganguren
html.description.abstractRetinal vessel oximetry is a new technology and needs detailed methodological scrutiny. We determine (1) the repeatability of retinal vessel oxygen saturation measurements, (2) whether measured saturation is different between retinal quadrants, and (3) whether the angle of gaze changes measurements of the same vessels. Fundus oximetry images were obtained from 26 healthy individuals, 18 to 30 years old, using the Oxymap retinal oximeter. Oxygen saturation in the same vessel segments was compared between two similar images of each individual to determine repeatability. Vessel oxygen saturation was also compared between different quadrants of the retina in the same oximetry image. Finally, oxygen saturation measurements were made on the same vessel segments at different angles of gaze. Mean and standard deviation of saturation measurements was 93.1% ± 2.3% in arterioles and 64.9% ± 3.3% in venules. Standard deviation of repeated saturation measurements on the same vessel segment was 1.0% in arterioles and 1.4% in venules. Significant differences were seen between retinal quadrants. When angle of gaze was altered, measured saturation was lower in the same vessels when they were located in the inferior portion compared with other parts of the image (-1.3% ± 1.7%, P = 0.0004 in arterioles and -1.9 ± 2.4%, P = 0.0007 in venules). Retinal vessel oxygen saturation measurements are repeatable with a small standard deviation. When oximetry results are compared between time points or eyes, the imaging must be standardized and similar parts of the images analyzed.


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