• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Perner, Anders
Haase, Nicolai
Guttormsen, Anne B
Tenhunen, Jyrki
Klemenzson, Gudmundur
Åneman, Anders
Madsen, Kristian R
Møller, Morten H
Elkjær, Jeanie M
Poulsen, Lone M
Bendtsen, Asger
Winding, Robert
Steensen, Morten
Berezowicz, Pawel
Søe-Jensen, Peter
Bestle, Morten
Strand, Kristian
Wiis, Jørgen
White, Jonathan O
Thornberg, Klaus J
Quist, Lars
Nielsen, Jonas
Andersen, Lasse H
Holst, Lars B
Thormar, Katrin
Kjældgaard, Anne-Lene
Fabritius, Maria L
Mondrup, Frederik
Pott, Frank C
Møller, Thea P
Winkel, Per
Wetterslev, Jørn
Show allShow less
Issue Date
2012-07-12

Metadata
Show full item record
Citation
N. Engl. J. Med. 2012, 367 (2):124-34
Abstract
Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day. The primary outcome measure was either death or end-stage kidney failure (dependence on dialysis) at 90 days after randomization. Of the 804 patients who underwent randomization, 798 were included in the modified intention-to-treat population. The two intervention groups had similar baseline characteristics. At 90 days after randomization, 201 of 398 patients (51%) assigned to HES 130/0.42 had died, as compared with 172 of 400 patients (43%) assigned to Ringer's acetate (relative risk, 1.17; 95% confidence interval [CI], 1.01 to 1.36; P=0.03); 1 patient in each group had end-stage kidney failure. In the 90-day period, 87 patients (22%) assigned to HES 130/0.42 were treated with renal-replacement therapy versus 65 patients (16%) assigned to Ringer's acetate (relative risk, 1.35; 95% CI, 1.01 to 1.80; P=0.04), and 38 patients (10%) and 25 patients (6%), respectively, had severe bleeding (relative risk, 1.52; 95% CI, 0.94 to 2.48; P=0.09). The results were supported by multivariate analyses, with adjustment for known risk factors for death or acute kidney injury at baseline. Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.42 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate. (Funded by the Danish Research Council and others; 6S ClinicalTrials.gov number, NCT00962156.)
Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links
http://dx.doi.org/10.1056/NEJMoa1204242
http://www.nejm.org/doi/full/10.1056/NEJMoa1204242
Rights
Archived with thanks to The New England journal of medicine
ae974a485f413a2113503eed53cd6c53
10.1056/NEJMoa1204242
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Hydroxyethyl starch in severe sepsis: end of starch era?
  • Authors: Estrada CA, Murugan R
  • Issue date: 2013 Mar 13
  • Hydroxyethyl starch in sepsis.
  • Authors: Haase NR
  • Issue date: 2014 Jan
  • Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate.
  • Authors: Perner A, Haase N, Winkel P, Guttormsen AB, Tenhunen J, Klemenzson G, Müller RG, Aneman A, Wetterslev J
  • Issue date: 2014 Jul
  • Acute kidney injury with hydroxyethyl starch 130/0.42 in severe sepsis.
  • Authors: Müller RB, Haase N, Lange T, Wetterslev J, Perner A
  • Issue date: 2015 Mar
  • Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial.
  • Authors: Béchir M, Puhan MA, Fasshauer M, Schuepbach RA, Stocker R, Neff TA
  • Issue date: 2013 Dec 23

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.