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Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1.

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Authors
Ribasés, Marta
Ramos-Quiroga, Josep Antoni
Hervás, Amaia
Sánchez-Mora, Cristina
Bosch, Rosa
Bielsa, Anna
Gastaminza, Xavier
Lesch, Klaus-Peter
Reif, Andreas
Renner, Tobias J
Romanos, Marcel
Warnke, Andreas
Walitza, Susanne
Freitag, Christine
Meyer, Jobst
Palmason, Haukur
Casas, Miquel
Bayés, Mònica
Cormand, Bru
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Issue Date
2012-04

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Citation
World J. Biol. Psychiatry 2012, 13(4):281-92
Abstract
Several pharmacological and genetic studies support the involvement of the dopamine neurotransmitter system in the aetiology of attention-deficit hyperactivity disorder (ADHD). Based on this information we evaluated the contribution to ADHD of nine genes involved in dopaminergic neurotransmission (DRD1, DRD2, DRD3, DRD4, DRD5, DAT1, TH, DBH and COMT). We genotyped a total of 61 tagging single nucleotide polymorphisms (SNPs) in a sample of 533 ADHD patients (322 children and 211 adults), 533 sex-matched unrelated controls and additional 196 nuclear ADHD families from Spain. The single- and multiple-marker analysis in both population and family-based approaches provided preliminary evidence for the contribution of DRD1 to combined-type ADHD in children (P=8.8e-04; OR=1.50 (1.18-1.90) and P=0.0061; OR=1.73 (1.23-2.45)) but not in adults. Subsequently, we tested positive results for replication in an independent sample of 353 German families with combined-type ADHD children and replicated the initial association between DRD1 and childhood ADHD (P=8.4e-05; OR=3.67 (2.04-6.63)). The replication of the association between DRD1 and ADHD in two European cohorts highlights the validity of our finding and supports the involvement of DRD1 in childhood ADHD.
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http://dx.doi.org/10.3109/15622975.2011.584905
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Archived with thanks to The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
ae974a485f413a2113503eed53cd6c53
10.3109/15622975.2011.584905
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