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Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

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Authors
Siggeirsdottir, Kristin
Aspelund, Thor
Jonsson, Brynjolfur Y
Mogensen, Brynjolfur
Launer, Lenore J
Harris, Tamara B
Sigurdsson, Gunnar
Gudnason, Vilmundur
Issue Date
2012-05

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Citation
Age Ageing 2012, 41(3):351-7
Abstract
Understanding the determinants of health burden after a fracture in ageing populations is important. Assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation. Individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years. A total of 5,764 individuals, 57.7% women, born 1907-35, mean age 77. Method: four groups with a verified fracture status were used; vertebral fractures, other osteoporotic fractures excluding vertebral, non-osteoporotic fractures and not-fractured were compared and analysed for the effect on mobility, strength, QoL, ADL, co-morbidity and hospitalisation. Worst performance on functional tests was in the vertebral fracture group for women (P < 0.0001) and the other osteoporotic fractures group for men (P < 0.05). Both vertebral and other osteoporotic fractures, showed an increased risk of hospitalisation, HR = 1.4 (95% CI: 1.3-1.7) and 1.2 (95% CI: 1.1-1.2) respectively (P < 0.0001). Individuals with vertebral fractures had 50% (P < 0.0001) longer hospitalisation than not-fractured and 33% (P < 0.002) longer than the other osteoporotic fractures group. Individuals with a history of clinical vertebral fracture seem to carry the greatest health burden compared with other fracture groups, emphasising the attention which should be given to those individuals.
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http://dx.doi.org/10.1093/ageing/afs003
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335370/pdf/afs003.pdf
http://ageing.oxfordjournals.org/content/41/3/351
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Archived with thanks to Age and ageing
ae974a485f413a2113503eed53cd6c53
10.1093/ageing/afs003
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English Journal Articles (Peer Reviewed)

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