Showing items related by title, author, creator and subject.

• Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

  Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John R B; Yuan, Xin; Scott, Robert A; Henneman, Peter; Heid, Iris M; Kizer, Jorge R; Lyytikäinen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroula; Pankow, James S; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J; Greenwood, Celia M T; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E; Vollenweider, Peter; Kapur, Karen A; Chambers, John; Wareham, Nicholas J; Langenberg, Claudia; Frants, Rune; Willems-Vandijk, Ko; Oostra, Ben A; Willems, Sara M; Lamina, Claudia; Winkler, Thomas W; Psaty, Bruce M; Tracy, Russell P; Brody, Jennifer; Chen, Ida; Viikari, Jorma; Kähönen, Mika; Pramstaller, Peter P; Evans, David M; St Pourcain, Beate; Sattar, Naveed; Wood, Andrew R; Bandinelli, Stefania; Carlson, Olga D; Egan, Josephine M; Böhringer, Stefan; van Heemst, Diana; Kedenko, Lyudmyla; Kristiansson, Kati; Nuotio, Marja-Liisa; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H-Erich; Deloukas, Panos; Katsareli, Efi; Couper, David J; Duncan, Bruce B; Kloppenburg, Margreet; Adair, Linda S; Borja, Judith B; Wilson, James G; Musani, Solomon; Guo, Xiuqing; Johnson, Toby; Semple, Robert; Teslovich, Tanya M; Allison, Matthew A; Redline, Susan; Buxbaum, Sarah G; Mohlke, Karen L; Meulenbelt, Ingrid; Ballantyne, Christie M; Dedoussis, George V; Hu, Frank B; Liu, Yongmei; Paulweber, Bernhard; Spector, Timothy D; Slagboom, P Eline; Ferrucci, Luigi; Jula, Antti; Perola, Markus; Raitakari, Olli; Florez, Jose C; Salomaa, Veikko; Eriksson, Johan G; Frayling, Timothy M; Hicks, Andrew A; Lehtimäki, Terho; Smith, George Davey; Siscovick, David S; Kronenberg, Florian; van Duijn, Cornelia; Loos, Ruth J F; Waterworth, Dawn M; Meigs, James B; Dupuis, Josee; Richards, J Brent; Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur; Dina, Christian; Welch, Ryan P; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S; Thorleifsson, Gudmar; McCulloch, Laura J; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J; Raychaudhuri, Soumya; McCarroll, Steve A; Hofmann, Oliver M; Segrè, Ayellet V; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Rafn; Bennett, Amanda J; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lori L; Boström, Kristina Bengtsson; Bravenboer, Bert; Bumpstead, Suzannah; Burtt, Noël P; Charpentier, Guillaume; Chines, Peter S; Cornelis, Marilyn; Crawford, Gabe; Doney, Alex S F; Elliott, Katherine S; Elliott, Amanda L; Erdos, Michael R; Fox, Caroline S; Franklin, Christopher S; Ganser, Martha; Gieger, Christian; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christopher J; Guiducci, Candace; Hadjadj, Samy; Hassanali, Neelam; Herder, Christian; Isomaa, Bo; Jackson, Anne U; Johnson, Paul R V; Jørgensen, Torben; Kao, Wen H L; Kong, Augustine; Kraft, Peter; Kuusisto, Johanna; Lauritzen, Torsten; Li, Man; Lieverse, Aloysius; Lindgren, Cecilia M; Lyssenko, Valeriya; Marre, Michel; Meitinger, Thomas; Midthjell, Kristian; Morken, Mario A; Narisu, Narisu; Nilsson, Peter; Owen, Katharine R; Payne, Felicity; Petersen, Ann-Kristin; Platou, Carl; Proença, Christine; Prokopenko, Inga; Rathmann, Wolfgang; Rayner, N William; Robertson, Neil R; Rocheleau, Ghislain; Roden, Michael; Sampson, Michael J; Saxena, Richa; Shields, Beverley M; Shrader, Peter; Sigurdsson, Gunnar; Sparsø, Thomas; Strassburger, Klaus; Stringham, Heather M; Sun, Qi; Swift, Amy J; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaija; van Dam, Rob M; van Haeften, Timon W; van Herpt, Thijs; van Vliet-Ostaptchouk, Jana V; Walters, G Bragi; Weedon, Michael N; Wijmenga, Cisca; Witteman, Jacqueline; Bergman, Richard N; Cauchi, Stephane; Collins, Francis S; Gloyn, Anna L; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A; Hitman, Graham A; Hofman, Albert; Hunter, David J; Hveem, Kristian; Laakso, Markku; Morris, Andrew D; Palmer, Colin N A; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D; Tuomilehto, Jaakko; Uitterlinden, Andre; Walker, Mark; Watanabe, Richard M; Abecasis, Goncalo R; Boehm, Bernhard O; Campbell, Harry; Daly, Mark J; Hattersley, Andrew T; Pedersen, Oluf; Barroso, Inês; Groop, Leif; Sladek, Rob; Thorsteinsdottir, Unnur; Wilson, James F; Illig, Thomas; Froguel, Philippe; van Duijn, Cornelia M; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I; Soranzo, Nicole; Wheeler, Eleanor; Glazer, Nicole L; Bouatia-Naji, Nabila; Mägi, Reedik; Randall, Joshua; Elliott, Paul; Rybin, Denis; Dehghan, Abbas; Hottenga, Jouke Jan; Song, Kijoung; Goel, Anuj; Lajunen, Taina; Doney, Alex; Cavalcanti-Proença, Christine; Kumari, Meena; Timpson, Nicholas J; Zabena, Carina; Ingelsson, Erik; An, Ping; O'Connell, Jeffrey; Luan, Jian'an; Elliott, Amanda; McCarroll, Steven A; Roccasecca, Rosa Maria; Pattou, François; Sethupathy, Praveen; Ariyurek, Yavuz; Barter, Philip; Beilby, John P; Ben-Shlomo, Yoav; Bergmann, Sven; Bochud, Murielle; Bonnefond, Amélie; Borch-Johnsen, Knut; Böttcher, Yvonne; Brunner, Eric; Bumpstead, Suzannah J; Chen, Yii-Der Ida; Chines, Peter; Clarke, Robert; Coin, Lachlan J M; Cooper, Matthew N; Crisponi, Laura; Day, Ian N M; de Geus, Eco J C; Delplanque, Jerome; Fedson, Annette C; Fischer-Rosinsky, Antje; Forouhi, Nita G; Franzosi, Maria Grazia; Galan, Pilar; Goodarzi, Mark O; Graessler, Jürgen; Grundy, Scott; Gwilliam, Rhian; Hallmans, Göran; Hammond, Naomi; Han, Xijing; Hartikainen, Anna-Liisa; Hayward, Caroline; Heath, Simon C; Hercberg, Serge; Hillman, David R; Hingorani, Aroon D; Hui, Jennie; Hung, Joe; Kaakinen, Marika; Kaprio, Jaakko; Kesaniemi, Y Antero; Kivimaki, Mika; Knight, Beatrice; Koskinen, Seppo; Kovacs, Peter; Kyvik, Kirsten Ohm; Lathrop, G Mark; Lawlor, Debbie A; Le Bacquer, Olivier; Lecoeur, Cécile; Li, Yun; Mahley, Robert; Mangino, Massimo; Martínez-Larrad, María Teresa; McAteer, Jarred B; McPherson, Ruth; Meisinger, Christa; Melzer, David; Meyre, David; Mitchell, Braxton D; Mukherjee, Sutapa; Naitza, Silvia; Neville, Matthew J; Orrù, Marco; Pakyz, Ruth; Paolisso, Giuseppe; Pattaro, Cristian; Pearson, Daniel; Peden, John F; Pedersen, Nancy L; Pfeiffer, Andreas F H; Pichler, Irene; Polasek, Ozren; Posthuma, Danielle; Potter, Simon C; Pouta, Anneli; Province, Michael A; Rayner, Nigel W; Rice, Kenneth; Ripatti, Samuli; Rivadeneira, Fernando; Rolandsson, Olov; Sandbaek, Annelli; Sandhu, Manjinder; Sanna, Serena; Sayer, Avan Aihie; Scheet, Paul; Seedorf, Udo; Sharp, Stephen J; Shields, Beverley; Sigurðsson, Gunnar; Sijbrands, Eric J G; Silveira, Angela; Simpson, Laila; Singleton, Andrew; Smith, Nicholas L; Sovio, Ulla; Swift, Amy; Syddall, Holly; Syvänen, Ann-Christine; Tönjes, Anke; Uitterlinden, André G; van Dijk, Ko Willems; Varma, Dhiraj; Visvikis-Siest, Sophie; Vitart, Veronique; Vogelzangs, Nicole; Waeber, Gérard; Wagner, Peter J; Walley, Andrew; Ward, Kim L; Watkins, Hugh; Wild, Sarah H; Willemsen, Gonneke; Witteman, Jaqueline C M; Yarnell, John W G; Zelenika, Diana; Zethelius, Björn; Zhai, Guangju; Zhao, Jing Hua; Zillikens, M Carola; Borecki, Ingrid B; Meneton, Pierre; Magnusson, Patrik K E; Nathan, David M; Williams, Gordon H; Silander, Kaisa; Bornstein, Stefan R; Schwarz, Peter; Spranger, Joachim; Karpe, Fredrik; Shuldiner, Alan R; Cooper, Cyrus; Serrano-Ríos, Manuel; Lind, Lars; Palmer, Lyle J; Hu, Frank B; Franks, Paul W; Ebrahim, Shah; Marmot, Michael; Kao, W H Linda; Pramstaller, Peter Paul; Wright, Alan F; Stumvoll, Michael; Hamsten, Anders; Buchanan, Thomas A; Valle, Timo T; Rotter, Jerome I; Penninx, Brenda W J H; Boomsma, Dorret I; Cao, Antonio; Scuteri, Angelo; Schlessinger, David; Uda, Manuela; Ruokonen, Aimo; Jarvelin, Marjo-Riitta; Peltonen, Leena; Mooser, Vincent; Sladek, Robert; Musunuru, Kiran; Smith, Albert V; Edmondson, Andrew C; Stylianou, Ioannis M; Koseki, Masahiro; Pirruccello, James P; Chasman, Daniel I; Johansen, Christopher T; Fouchier, Sigrid W; Peloso, Gina M; Barbalic, Maja; Ricketts, Sally L; Bis, Joshua C; Feitosa, Mary F; Orho-Melander, Marju; Melander, Olle; Li, Xiaohui; Li, Mingyao; Cho, Yoon Shin; Go, Min Jin; Kim, Young Jin; Lee, Jong-Young; Park, Taesung; Kim, Kyunga; Sim, Xueling; Ong, Rick Twee-Hee; Croteau-Chonka, Damien C; Lange, Leslie A; Smith, Joshua D; Ziegler, Andreas; Zhang, Weihua; Zee, Robert Y L; Whitfield, John B; Thompson, John R; Surakka, Ida; Spector, Tim D; Smit, Johannes H; Sinisalo, Juha; Scott, James; Saharinen, Juha; Sabatti, Chiara; Rose, Lynda M; Roberts, Robert; Rieder, Mark; Parker, Alex N; Pare, Guillaume; O'Donnell, Christopher J; Nieminen, Markku S; Nickerson, Deborah A; Montgomery, Grant W; McArdle, Wendy; Masson, David; Martin, Nicholas G; Marroni, Fabio; Lucas, Gavin; Luben, Robert; Lokki, Marja-Liisa; Lettre, Guillaume; Launer, Lenore J; Lakatta, Edward G; Laaksonen, Reijo; Kyvik, Kirsten O; König, Inke R; Khaw, Kay-Tee; Kaplan, Lee M; Johansson, Åsa; Janssens, A Cecile J W; Igl, Wilmar; Hovingh, G Kees; Hengstenberg, Christian; Havulinna, Aki S; Hastie, Nicholas D; Harris, Tamara B; Haritunians, Talin; Hall, Alistair S; Groop, Leif C; Gonzalez, Elena; Freimer, Nelson B; Erdmann, Jeanette; Ejebe, Kenechi G; Döring, Angela; Dominiczak, Anna F; Demissie, Serkalem; Deloukas, Panagiotis; de Faire, Ulf; Crawford, Gabriel; Chen, Yii-der I; Caulfield, Mark J; Boekholdt, S Matthijs; Assimes, Themistocles L; Quertermous, Thomas; Seielstad, Mark; Wong, Tien Y; Tai, E-Shyong; Feranil, Alan B; Kuzawa, Christopher W; Taylor, Herman A; Gabriel, Stacey B; Holm, Hilma; Gudnason, Vilmundur; Krauss, Ronald M; Ordovas, Jose M; Munroe, Patricia B; Kooner, Jaspal S; Tall, Alan R; Hegele, Robert A; Kastelein, John J P; Schadt, Eric E; Strachan, David P; Reilly, Muredach P; Samani, Nilesh J; Schunkert, Heribert; Cupples, L Adrienne; Sandhu, Manjinder S; Ridker, Paul M; Rader, Daniel J; Kathiresan, Sekar; Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada. (2012)

  Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
• A genome-wide association search for type 2 diabetes genes in African Americans.

  Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N; Ng, Maggie C Y; Langefeld, Carl D; Freedman, Barry I; Bowden, Donald W; Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur; Morris, Andrew P; Dina, Christian; Welch, Ryan P; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S; Thorleifsson, Gudmar; McCulloch, Laura J; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J; Raychaudhuri, Soumya; McCarroll, Steve A; Langenberg, Claudia; Hofmann, Oliver M; Dupuis, Josée; Qi, Lu; Segrè, Ayellet V; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Rafn; Bennett, Amanda J; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lori L; Boström, Kristina Bengtsson; Bravenboer, Bert; Bumpstead, Suzannah; Burtt, Noël P; Charpentier, Guillaume; Chines, Peter S; Cornelis, Marilyn; Couper, David J; Crawford, Gabe; Doney, Alex S F; Elliott, Katherine S; Elliott, Amanda L; Erdos, Michael R; Fox, Caroline S; Franklin, Christopher S; Ganser, Martha; Gieger, Christian; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christopher J; Guiducci, Candace; Hadjadj, Samy; Hassanali, Neelam; Herder, Christian; Isomaa, Bo; Jackson, Anne U; Johnson, Paul R V; Jørgensen, Torben; Kao, Wen H L; Klopp, Norman; Kong, Augustine; Kraft, Peter; Kuusisto, Johanna; Lauritzen, Torsten; Li, Man; Lieverse, Aloysius; Lindgren, Cecilia M; Lyssenko, Valeriya; Marre, Michel; Meitinger, Thomas; Midthjell, Kristian; Morken, Mario A; Narisu, Narisu; Nilsson, Peter; Owen, Katharine R; Payne, Felicity; Perry, John R B; Petersen, Ann-Kristin; Platou, Carl; Proença, Christine; Prokopenko, Inga; Rathmann, Wolfgang; Rayner, N William; Robertson, Neil R; Rocheleau, Ghislain; Roden, Michael; Sampson, Michael J; Saxena, Richa; Shields, Beverley M; Shrader, Peter; Sigurdsson, Gunnar; Sparsø, Thomas; Strassburger, Klaus; Stringham, Heather M; Sun, Qi; Swift, Amy J; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaija; van Dam, Rob M; van Haeften, Timon W; van Herpt, Thijs; van Vliet-Ostaptchouk, Jana V; Walters, G Bragi; Weedon, Michael N; Wijmenga, Cisca; Witteman, Jacqueline; Bergman, Richard N; Cauchi, Stephane; Collins, Francis S; Gloyn, Anna L; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A; Hitman, Graham A; Hofman, Albert; Hunter, David J; Hveem, Kristian; Laakso, Markku; Mohlke, Karen L; Morris, Andrew D; Palmer, Colin N A; Pramstaller, Peter P; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D; Tuomilehto, Jaakko; Uitterlinden, Andre; Walker, Mark; Wareham, Nicholas J; Watanabe, Richard M; Abecasis, Goncalo R; Boehm, Bernhard O; Campbell, Harry; Daly, Mark J; Hattersley, Andrew T; Hu, Frank B; Meigs, James B; Pankow, James S; Pedersen, Oluf; Wichmann, H-Erich; Barroso, Inês; Florez, Jose C; Frayling, Timothy M; Groop, Leif; Sladek, Rob; Thorsteinsdottir, Unnur; Wilson, James F; Illig, Thomas; Froguel, Philippe; van Duijn, Cornelia M; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I; Soranzo, Nicole; Wheeler, Eleanor; Glazer, Nicole L; Bouatia-Naji, Nabila; Mägi, Reedik; Randall, Joshua; Johnson, Toby; Elliott, Paul; Rybin, Denis; Henneman, Peter; Dehghan, Abbas; Hottenga, Jouke Jan; Song, Kijoung; Goel, Anuj; Egan, Josephine M; Lajunen, Taina; Doney, Alex; Kanoni, Stavroula; Cavalcanti-Proença, Christine; Kumari, Meena; Timpson, Nicholas J; Zabena, Carina; Ingelsson, Erik; An, Ping; O'Connell, Jeffrey; Luan, Jian'an; Elliott, Amanda; McCarroll, Steven A; Roccasecca, Rosa Maria; Pattou, François; Sethupathy, Praveen; Ariyurek, Yavuz; Barter, Philip; Beilby, John P; Ben-Shlomo, Yoav; Bergmann, Sven; Bochud, Murielle; Bonnefond, Amélie; Borch-Johnsen, Knut; Böttcher, Yvonne; Brunner, Eric; Bumpstead, Suzannah J; Chen, Yii-Der Ida; Chines, Peter; Clarke, Robert; Coin, Lachlan J M; Cooper, Matthew N; Crisponi, Laura; Day, Ian N M; de Geus, Eco J C; Delplanque, Jerome; Fedson, Annette C; Fischer-Rosinsky, Antje; Forouhi, Nita G; Frants, Rune; Franzosi, Maria Grazia; Galan, Pilar; Goodarzi, Mark O; Graessler, Jürgen; Grundy, Scott; Gwilliam, Rhian; Hallmans, Göran; Hammond, Naomi; Han, Xijing; Hartikainen, Anna-Liisa; Hayward, Caroline; Heath, Simon C; Hercberg, Serge; Hicks, Andrew A; Hillman, David R; Hingorani, Aroon D; Hui, Jennie; Hung, Joe; Jula, Antti; Kaakinen, Marika; Kaprio, Jaakko; Kesaniemi, Y Antero; Kivimaki, Mika; Knight, Beatrice; Koskinen, Seppo; Kovacs, Peter; Kyvik, Kirsten Ohm; Lathrop, G Mark; Lawlor, Debbie A; Le Bacquer, Olivier; Lecoeur, Cécile; Li, Yun; Mahley, Robert; Mangino, Massimo; Manning, Alisa K; Martínez-Larrad, María Teresa; McAteer, Jarred B; McPherson, Ruth; Meisinger, Christa; Melzer, David; Meyre, David; Mitchell, Braxton D; Mukherjee, Sutapa; Naitza, Silvia; Neville, Matthew J; Oostra, Ben A; Orrù, Marco; Pakyz, Ruth; Paolisso, Giuseppe; Pattaro, Cristian; Pearson, Daniel; Peden, John F; Pedersen, Nancy L; Perola, Markus; Pfeiffer, Andreas F H; Pichler, Irene; Polasek, Ozren; Posthuma, Danielle; Potter, Simon C; Pouta, Anneli; Province, Michael A; Psaty, Bruce M; Rayner, Nigel W; Rice, Kenneth; Ripatti, Samuli; Rivadeneira, Fernando; Rolandsson, Olov; Sandbaek, Annelli; Sandhu, Manjinder; Sanna, Serena; Sayer, Avan Aihie; Scheet, Paul; Seedorf, Udo; Sharp, Stephen J; Shields, Beverley; Sijbrands, Eric J G; Silveira, Angela; Simpson, Laila; Singleton, Andrew; Smith, Nicholas L; Sovio, Ulla; Swift, Amy; Syddall, Holly; Syvänen, Ann-Christine; Tanaka, Toshiko; Tönjes, Anke; Uitterlinden, André G; van Dijk, Ko Willems; Varma, Dhiraj; Visvikis-Siest, Sophie; Vitart, Veronique; Vogelzangs, Nicole; Waeber, Gérard; Wagner, Peter J; Walley, Andrew; Ward, Kim L; Watkins, Hugh; Wild, Sarah H; Willemsen, Gonneke; Witteman, Jaqueline C M; Yarnell, John W G; Zelenika, Diana; Zethelius, Björn; Zhai, Guangju; Zhao, Jing Hua; Zillikens, M Carola; Borecki, Ingrid B; Loos, Ruth J F; Meneton, Pierre; Magnusson, Patrik K E; Nathan, David M; Williams, Gordon H; Silander, Kaisa; Salomaa, Veikko; Smith, George Davey; Bornstein, Stefan R; Schwarz, Peter; Spranger, Joachim; Karpe, Fredrik; Shuldiner, Alan R; Cooper, Cyrus; Dedoussis, George V; Serrano-Ríos, Manuel; Lind, Lars; Palmer, Lyle J; Franks, Paul W; Ebrahim, Shah; Marmot, Michael; Kao, W H Linda; Pramstaller, Peter Paul; Wright, Alan F; Stumvoll, Michael; Hamsten, Anders; Buchanan, Thomas A; Valle, Timo T; Rotter, Jerome I; Siscovick, David S; Penninx, Brenda W J H; Boomsma, Dorret I; Deloukas, Panos; Spector, Timothy D; Ferrucci, Luigi; Cao, Antonio; Scuteri, Angelo; Schlessinger, David; Uda, Manuela; Ruokonen, Aimo; Jarvelin, Marjo-Riitta; Waterworth, Dawn M; Vollenweider, Peter; Peltonen, Leena; Mooser, Vincent; Sladek, Robert; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America. nallred@wfubmc.edu (2012)

  African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
• 

  Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

  Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San; Choi, Seung-Hoan; Harold, Denise; Jones, Lesley; Holmans, Peter; Gerrish, Amy; Vedernikov, Alexey; Richards, Alexander; DeStefano, Anita L; Farrer, Lindsay A; Farrer, Lindsay A; van Duijn, Cornelia M; van Duijn, Cornelia M; Ramirez, Alfredo; Ramirez, Alfredo; Seshadri, Sudha; Seshadri, Sudha; Schellenberg, Gerard D; Schellenberg, Gerard D; Amouyel, Philippe; Amouyel, Philippe; Williams, Julie; Williams, Julie; Russo, Giancarlo; Russo, Giancarlo; Thornton-Wells, Tricia A; Thornton-Wells, Tricia A; Denning, Nicola; Denning, Nicola; Scarpini, Elio; Scarpini, Elio; Smith, Albert V; Smith, Albert V; Chouraki, Vincent; Chouraki, Vincent; Thomas, Charlene; Thomas, Charlene; Ikram, M Arfan; Ikram, M Arfan; Zelenika, Diana; Zelenika, Diana; Vardarajan, Badri N; Vardarajan, Badri N; Kamatani, Yoichiro; Kamatani, Yoichiro; Lin, Chiao-Feng; Lin, Chiao-Feng; Schmidt, Helena; Schmidt, Helena; Kunkle, Brian; Kunkle, Brian; Bonuccelli, Ubaldo; Bonuccelli, Ubaldo; Dunstan, Melanie L; Dunstan, Melanie L; Vronskaya, Maria; Vronskaya, Maria; Johnson, Andrew D; Johnson, Andrew D; Ruiz, Agustin; Ruiz, Agustin; Bihoreau, Marie-Thérèse; Bihoreau, Marie-Thérèse; Reitz, Christiane; Reitz, Christiane; Pasquier, Florence; Pasquier, Florence; Hollingworth, Paul; Hollingworth, Paul; Hanon, Olivier; Hanon, Olivier; Fitzpatrick, Annette L; Fitzpatrick, Annette L; Mancuso, Michelangelo; Mancuso, Michelangelo; Buxbaum, Joseph D; Buxbaum, Joseph D; Campion, Dominique; Campion, Dominique; Crane, Paul K; Crane, Paul K; Baldwin, Clinton; Baldwin, Clinton; Becker, Tim; Becker, Tim; Gudnason, Vilmundur; Gudnason, Vilmundur; Cruchaga, Carlos; Cruchaga, Carlos; Craig, David; Craig, David; Amin, Najaf; Amin, Najaf; Berr, Claudine; Berr, Claudine; Siciliano, Gabriele; Siciliano, Gabriele; Lopez, Oscar L; Lopez, Oscar L; De Jager, Philip L; De Jager, Philip L; Deramecourt, Vincent; Deramecourt, Vincent; Johnston, Janet A; Johnston, Janet A; Evans, Denis; Evans, Denis; Lovestone, Simon; Lovestone, Simon; Letenneur, Luc; Letenneur, Luc; Hernández, Isabel; Hernández, Isabel; Rubinsztein, David C; Rubinsztein, David C; Eiriksdottir, Gudny; Eiriksdottir, Gudny; Moebus, Susanne; Moebus, Susanne; Sleegers, Kristel; Sleegers, Kristel; Goate, Alison M; Goate, Alison M; Fiévet, Nathalie; Fiévet, Nathalie; Huentelman, Matthew J; Huentelman, Matthew J; Gill, Michael; Gill, Michael; Brown, Kristelle; Brown, Kristelle; Kamboh, M Ilyas; Kamboh, M Ilyas; Keller, Lina; Keller, Lina; Barberger-Gateau, Pascale; Barberger-Gateau, Pascale; McGuinness, Bernadette; McGuinness, Bernadette; Mecocci, Patrizia; Mecocci, Patrizia; Larson, Eric B; Larson, Eric B; Myers, Amanda J; Myers, Amanda J; Dufouil, Carole; Dufouil, Carole; Todd, Stephen; Todd, Stephen; Wallon, David; Wallon, David; Love, Seth; Love, Seth; Rogaeva, Ekaterina; Rogaeva, Ekaterina; Gallacher, John; Gallacher, John; George-Hyslop, Peter St; George-Hyslop, Peter St; Clarimon, Jordi; Clarimon, Jordi; Zompo, Maria Del; Zompo, Maria Del; Lleo, Alberto; Lleo, Alberto; Bayer, Anthony; Bayer, Anthony; Tsuang, Debby W; Tsuang, Debby W; Yu, Lei; Yu, Lei; Tsolaki, Magda; Tsolaki, Magda; Bossù, Paola; Bossù, Paola; Spalletta, Gianfranco; Spalletta, Gianfranco; Proitsi, Petra; Proitsi, Petra; Collinge, John; Collinge, John; Sorbi, Sandro; Sorbi, Sandro; Maier, Wolfgang; Maier, Wolfgang; Garcia, Florentino Sanchez; Garcia, Florentino Sanchez; Fox, Nick C; Fox, Nick C; Hardy, John; Hardy, John; Naranjo, Maria Candida Deniz; Naranjo, Maria Candida Deniz; Bosco, Paolo; Bosco, Paolo; Clarke, Robert; Clarke, Robert; Brayne, Carol; Brayne, Carol; Galimberti, Daniela; Galimberti, Daniela; Hampel, Harald; Hampel, Harald; Pilotto, Alberto; Pilotto, Alberto; Lambert, Jean-Charles; Lambert, Jean-Charles; Frank-García, Ana; Frank-García, Ana; Panza, Francesco; Panza, Francesco; Solfrizzi, Vincenzo; Solfrizzi, Vincenzo; Caffarra, Paolo; Caffarra, Paolo; Nacmias, Benedetta; Nacmias, Benedetta; Perry, William; Perry, William; Mayhaus, Manuel; Mayhaus, Manuel; Lannfelt, Lars; Lannfelt, Lars; Hakonarson, Hakon; Hakonarson, Hakon; Pichler, Sabrina; Pichler, Sabrina; Ibrahim-Verbaas, Carla A; Ibrahim-Verbaas, Carla A; Carrasquillo, Minerva M; Carrasquillo, Minerva M; Ingelsson, Martin; Ingelsson, Martin; Beekly, Duane; Beekly, Duane; Alvarez, Victoria; Alvarez, Victoria; Zou, Fanggeng; Zou, Fanggeng; Valladares, Otto; Valladares, Otto; Younkin, Steven G; Younkin, Steven G; Coto, Eliecer; Coto, Eliecer; Hamilton-Nelson, Kara L; Hamilton-Nelson, Kara L; Gu, Wei; Gu, Wei; Naj, Adam C; Naj, Adam C; Razquin, Cristina; Razquin, Cristina; Pastor, Pau; Pastor, Pau; Mateo, Ignacio; Mateo, Ignacio; Owen, Michael J; Owen, Michael J; Faber, Kelley M; Faber, Kelley M; Jonsson, Palmi V; Jonsson, Palmi V; Combarros, Onofre; Combarros, Onofre; O'Donovan, Michael C; O'Donovan, Michael C; Cantwell, Laura B; Cantwell, Laura B; Soininen, Hilkka; Soininen, Hilkka; Sims, Rebecca; Sims, Rebecca; Blacker, Deborah; Blacker, Deborah; Mead, Simon; Mead, Simon; Mosley, Thomas H; Mosley, Thomas H; Bennett, David A; Bennett, David A; Harris, Tamara B; Harris, Tamara B; Fratiglioni, Laura; Fratiglioni, Laura; Holmes, Clive; Holmes, Clive; de Bruijn, Renee F A G; de Bruijn, Renee F A G; Passmore, Peter; Passmore, Peter; Montine, Thomas J; Montine, Thomas J; Jun, Gyungah; Jun, Gyungah; Bettens, Karolien; Bettens, Karolien; Rotter, Jerome I; Rotter, Jerome I; Brice, Alexis; Brice, Alexis; Morgan, Kevin; Morgan, Kevin; Foroud, Tatiana M; Foroud, Tatiana M; Kukull, Walter A; Kukull, Walter A; Hannequin, Didier; Hannequin, Didier; Powell, John F; Powell, John F; Nalls, Michael A; Nalls, Michael A; Ritchie, Karen; Ritchie, Karen; Bis, Joshua C; Bis, Joshua C; Lunetta, Kathryn L; Lunetta, Kathryn L; Kauwe, John S K; Kauwe, John S K; Boerwinkle, Eric; Boerwinkle, Eric; Riemenschneider, Matthias; Riemenschneider, Matthias; Boada, Mercè; Boada, Mercè; Hiltunen, Mikko; Hiltunen, Mikko; Martin, Eden R; Martin, Eden R; Schmidt, Reinhold; Schmidt, Reinhold; Rujescu, Dan; Rujescu, Dan; Dartigues, Jean-François; Dartigues, Jean-François; Beecham, Gary W; Beecham, Gary W; Mayeux, Richard; Mayeux, Richard; Tzourio, Christophe; Tzourio, Christophe; Hofman, Albert; Hofman, Albert; Nöthen, Markus M; Nöthen, Markus M; Graff, Caroline; Graff, Caroline; Psaty, Bruce M; Psaty, Bruce M; Haines, Jonathan L; Haines, Jonathan L; Lathrop, Mark; Lathrop, Mark; Pericak-Vance, Margaret A; Pericak-Vance, Margaret A; Launer, Lenore J; Launer, Lenore J; Grenier-Boley, Benjamin; Grenier-Boley, Benjamin; Van Broeckhoven, Christine; Van Broeckhoven, Christine; [ 1 ] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales [ 2 ] INSERM, U744, F-59045 Lille, France [ 3 ] Univ Lille 2, Lille, France [ 4 ] Inst Pasteur, F-59019 Lille, France [ 5 ] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA [ 6 ] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA [ 7 ] Erasmus MC Univ Med Ctr, Dept Epidemiol & Neurol, Rotterdam, Netherlands [ 8 ] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA [ 9 ] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA [ 10 ] Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA [ 11 ] Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA [ 12 ] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA [ 13 ] Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA [ 14 ] Univ Miami, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL USA [ 15 ] ETH Univ Zurich, Funct Genom Ctr Zurich, Zurich, Switzerland [ 16 ] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA [ 17 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 18 ] Iceland Heart Assoc, Kopavogur, Iceland [ 19 ] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA [ 20 ] Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands [ 21 ] Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands [ 22 ] Erasmus MC Univ Med Ctr, Dept Radiol, Rotterdam, Netherlands [ 23 ] Netherlands Consortium Hlth Aging, Leiden, Netherlands [ 24 ] CEA, Inst Genom, Ctr Natl Genotypage, Evry, France [ 25 ] Fdn Jean Dausset CEPH, Paris, France [ 26 ] Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria [ 27 ] UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England [ 28 ] NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Framingham Heart Study, Framingham, MA USA [ 29 ] Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona, Spain [ 30 ] Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA [ 31 ] Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY USA [ 32 ] CHRU Lille, CNR MAJ, F-59037 Lille, France [ 33 ] Univ Paris 05, Sorbonne Paris 5, Broca Hosp, Dept Geriatr, Paris, France [ 34 ] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA [ 35 ] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA [ 36 ] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA [ 37 ] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA [ 38 ] Mt Sinai Sch Med, Dept Genet, New York, NY USA [ 39 ] Mt Sinai Sch Med, Dept Genom Sci, New York, NY USA [ 40 ] Rouen Univ Hosp, CNR MAJ, INSERM, U1079, F-76031 Rouen, France [ 41 ] Univ Washington, Dept Med, Seattle, WA USA [ 42 ] Univ Bonn, German Ctr Neurodegenerat Dis DZNE, Bonn, Germany [ 43 ] Univ Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany [ 44 ] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA [ 45 ] Washington Univ, Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA [ 46 ] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland [ 47 ] Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands [ 48 ] Hop Colombiere, Fac Med, INSERM, U1061, Montpellier, France [ 49 ] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA [ 50 ] Brigham & Womens Hosp, Dept Neurol & Psychiat, Inst Neurosci, Program Translat NeuroPsychiat Genom, Boston, MA 02115 USA [ 51 ] Harvard Univ, Sch Med, Boston, MA USA [ 52 ] Broad Inst, Program Med & Populat Genet, Boston, MA USA [ 53 ] Rush Univ, Med Ctr, Dept Internal Med, Rush Inst Hlth Aging, Chicago, IL 60612 USA [ 54 ] Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England [ 55 ] Victor Segalen Univ, INSERM, U897, F-33076 Bordeaux, France [ 56 ] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England [ 57 ] Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium [ 58 ] Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium [ 59 ] Translat Genom Res Inst, Neurogen Div, Phoenix, AZ USA [ 60 ] Univ Dublin Trinity Coll, Discipline Psychiat, Dublin 2, Ireland [ 61 ] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2RD, England [ 62 ] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA [ 63 ] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA USA [ 64 ] Karolinska Inst, Dept Neurobiol, Care Sci & Soc, Aging Reasearch Ctr, Stockholm, Sweden [ 65 ] Stockholm Univ, S-10691 Stockholm, Sweden [ 66 ] Grp Hlth Res Inst, Grp Hlth, Seattle, WA USA [ 67 ] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA [ 68 ] Univ Bristol, Inst Clin Neurosci, Sch Clin Sci, Frenchay Hosp, Bristol, Avon, England [ 69 ] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada [ 70 ] Cardiff Univ, Neuadd Meirionnydd, Univ Wales Hosp, Inst Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales [ 71 ] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England [ 72 ] Univ Cambridge, Dept Clin Neurosci, Cambridge, England [ 73 ] Univ Autonoma Barcelona, St Pau Hosp, IIB St Pau, Dept Neurol, E-08193 Barcelona, Spain [ 74 ] Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain [ 75 ] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA [ 76 ] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA [ 77 ] Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece [ 78 ] Fdn Santa Lucia, Rome, Italy [ 79 ] UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England [ 80 ] Univ Florence, NEUROFARBA Dept Neurosci Psychol Drug Res & Child, Florence, Italy [ 81 ] Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, Florence, Italy [ 82 ] Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain [ 83 ] UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England [ 84 ] Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England [ 85 ] Inst Neurol, Reta Lilla Weston Labs, London WC1N 3BG, England [ 86 ] IRCCS Assoc Oasi Maria SS, Troina, Italy [ 87 ] Univ Oxford, Clin Trial Serv Unit, OHAP, Oxford, England [ 88 ] Univ Cambridge, Inst Publ Hlth, CFAS, Cambridge, England [ 89 ] Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy [ 90 ] Univ Pisa, Neurol Clin, Pisa, Italy [ 91 ] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany [ 92 ] Univ Perugia, Dept Clin & Expt Med, Sect Gerontol & Geriatr, I-06100 Perugia, Italy [ 93 ] Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy [ 94 ] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany [ 95 ] German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany [ 96 ] Goethe Univ Frankfurt, Dept Psychiat, D-60054 Frankfurt, Germany [ 97 ] Univ Munich, Dept Psychiat, D-80539 Munich, Germany [ 98 ] IRCCS Casa Sollievo Sofferenza, Gerontol & Geriatr Res Lab, San Giovanni Rotondo, Italy [ 99 ] Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid, Spain [ 100 ] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain [ 101 ] Hosp la Paz IdIPaz, Inst Invest Sanitaria, Madrid, Spain [ 102 ] Univ Bari, Ctr Aging Brain, Dept Geriatr, Bari, Italy [ 103 ] Univ Parma, Dept Neurosci, I-43100 Parma, Italy [ 104 ] Ctr Cognit Disorders AUSL, Parma, Italy [ 105 ] Univ Hosp, Dept Psychiat, Saarland, Germany [ 106 ] Uppsala Univ, Dept Publ Health Geriatr, Uppsala, Sweden [ 107 ] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA [ 108 ] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA [ 109 ] Univ Washington, Natl Alzheimers Coordinating Ctr, Seattle, WA 98195 USA [ 110 ] Genet Mol Huca Oviedo, Oviedo, Spain [ 111 ] Univ Hosp, Dept Psychiat, Saarland, Germany [ 112 ] Univ Navarra, Sch Med, Ctr Appl Med Res, Neurogenet Lab,Div Neurosci, E-31080 Pamplona, Spain [ 113 ] Inst Salud Carlos III, Ctr Invest Biome Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain [ 114 ] Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, E-39005 Santander, Spain [ 115 ] Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain [ 116 ] IFIMAV, Santander, Spain [ 117 ] Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA [ 118 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 119 ] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland [ 120 ] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland [ 121 ] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA [ 122 ] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA [ 123 ] Univ Mississippi, Med Ctr, Dept Geriatr Med, Jackson, MS 39216 USA [ 124 ] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA [ 125 ] NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA [ 126 ] Karolinska Inst, Care Sci & Soc, Dept Neurobiol, Aging Res Ctr, Stockholm, Sweden [ 127 ] Karolinska Univ Hosp Huddinge, Genet Unit, Dept Geriatr Med, Stockholm, Sweden [ 128 ] Univ Southampton, Sch Med, Div Clin Neurosci, Southampton, Hants, England [ 129 ] Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands [ 130 ] Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands [ 131 ] Univ Washington, Dept Pathol, Seattle, WA 98195 USA [ 132 ] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA [ 133 ] Univ Paris 06, INSERM UMR S975 CNRS UMR 7225, Ctr Rech, Inst Cerveau & Moelle Epiniere CRICM,Hop Salpetri, Paris, France [ 134 ] Hop La Pitie Salpetriere, AP HP, Paris, France [ 135 ] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA [ 136 ] NIA, Neurogenet Lab, Intramural Res Program, Bethesda, MD 20892 USA [ 137 ] Univ London Imperial Coll Sci Technol & Med, London, England [ 138 ] Brigham Young Univ, Dept Biol, Provo, UT 84602 USA [ 139 ] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA [ 140 ] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA [ 141 ] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA [ 142 ] Univ Autonoma Barcelona VHIR UAB, Inst Recerca, Hosp Univ Vall d Hebron, Barcelona, Spain [ 143 ] Med Univ Graz, Dept Neurol, Graz, Austria [ 144 ] CHU Bordeaux, Ctr Memoire Ressources & Rech Bordeaux, Bordeaux, France [ 145 ] Victor Segalen Univ, INSERM, U708, Bordeaux, France [ 146 ] Univ Bonn, Life & Brain Ctr, Dept Genom, Inst Human Genet, Bonn, Germany [ 147 ] Karolinska Inst, Dept Neurobiol, Care Sci & Soc, KIADRC, Stockholm, Sweden [ 148 ] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA [ 149 ] Vanderbilt Univ, Vanderbilt Ctr Human Genet Res, Nashville, TN 37235 USA [ 150 ] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA [ 151 ] McGill Univ, Montreal, PQ, Canada [ 152 ] Genome Quebec Innovat Ctr, Montreal, PQ, Canada [ 153 ] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA [ 154 ] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA [ 155 ] Ctr Med Syst Biol, Leiden, Netherlands [ 156 ] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany [ 157 ] Univ Bonn, Inst Human Genet, Bonn, Germany [ 158 ] Framingham Heart Dis Epidemiol Study, Framingham, MA USA [ 159 ] CHRU Lille, F-59037 Lille, France (Public Library Science, 2014)

  Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.