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dc.contributor.authorThorsteinsson, Hunbogi
dc.contributor.authorAlexandersson, Asgeir
dc.contributor.authorOskarsdottir, Gudrun N
dc.contributor.authorSkuladottir, Rut
dc.contributor.authorIsaksson, Helgi J
dc.contributor.authorJonsson, Steinn
dc.contributor.authorGudbjartsson, Tomas
dc.date.accessioned2013-09-19T14:16:40Z
dc.date.available2013-09-19T14:16:40Z
dc.date.issued2012-07
dc.date.submitted2013-09-19
dc.identifier.citationJ Thorac Oncol 2012, 7(7):1164-9en_GB
dc.identifier.issn1556-1380
dc.identifier.pmid22592213
dc.identifier.doi10.1097/JTO.0b013e318252d022
dc.identifier.urihttp://hdl.handle.net/2336/301916
dc.description.abstractThe proportion of patients with non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent is one measure of effectiveness in treating lung cancer. To the best of our knowledge, surgical resection rate (SRR) for a whole nation has never been reported before. We studied the SRR and surgical outcome of NSCLC patients in Iceland during a recent 15-year period. This was a retrospective study of all pulmonary resections performed with curative intent for NSCLC in Iceland from 1994 to 2008. Information was retrieved from medical records and from the Icelandic Cancer Registry. Patient demographics, postoperative tumor, node, metastasis stage, overall survival, and complication rates were compared over three 5-year periods. Of 1530 confirmed cases of NSCLC, 404 were resected, giving an SRR of 26.4%, which did not change significantly during the study period. Minor and major complication rates were 37.4% and 8.7%, respectively. Operative mortality rates were 0.7% for lobectomy, 3.3% for pneumonectomy, and 0% for lesser resection. Five-year survival after all procedures was 40.7% and improved from the first to the last 5-year period (34.8% versus 43.8%, p = 0.04). Five-year survival for stages I and II together was 46.8%, with no significant change in stage distribution between periods. Five-year survival after pneumonectomy was 22.0%, which was significantly lower than for lobectomy (44.6%) and lesser resection (40.7%) (p < 0.005). Unoperated patients had a 5-year survival of 4.8%, as compared to 12.4% for all the NSCLC patients together. Compared with most other published studies, the SRR of NSCLC in Iceland is high. Short-term outcome is good, with a low rate of major complications and an operative mortality of only 1.0%. Five-year survival improved significantly over the study period.
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen_GB
dc.relation.urlhttp://dx.doi.org/10.1097/JTO.0b013e318252d022en_GB
dc.rightsArchived with thanks to Journal of thoracic oncology : official publication of the International Association for the Study of Lung Canceren_GB
dc.subject.meshAdenocarcinomaen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshCarcinoma, Non-Small-Cell Lungen_GB
dc.subject.meshCarcinoma, Squamous Cellen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshLung Neoplasmsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMedical Recordsen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNeoplasm Metastasisen_GB
dc.subject.meshNeoplasm Stagingen_GB
dc.subject.meshPneumonectomyen_GB
dc.subject.meshPostoperative Complicationsen_GB
dc.subject.meshPrognosisen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshSurvival Rateen_GB
dc.titleResection rate and outcome of pulmonary resections for non-small-cell lung cancer: a nationwide study from Iceland.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, and †Department of Cardiothoracic Surgery, University of Iceland, Reykjavik, Iceland.en_GB
dc.identifier.journalJournal of thoracic oncology : official publication of the International Association for the Study of Lung Canceren_GB
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractThe proportion of patients with non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent is one measure of effectiveness in treating lung cancer. To the best of our knowledge, surgical resection rate (SRR) for a whole nation has never been reported before. We studied the SRR and surgical outcome of NSCLC patients in Iceland during a recent 15-year period. This was a retrospective study of all pulmonary resections performed with curative intent for NSCLC in Iceland from 1994 to 2008. Information was retrieved from medical records and from the Icelandic Cancer Registry. Patient demographics, postoperative tumor, node, metastasis stage, overall survival, and complication rates were compared over three 5-year periods. Of 1530 confirmed cases of NSCLC, 404 were resected, giving an SRR of 26.4%, which did not change significantly during the study period. Minor and major complication rates were 37.4% and 8.7%, respectively. Operative mortality rates were 0.7% for lobectomy, 3.3% for pneumonectomy, and 0% for lesser resection. Five-year survival after all procedures was 40.7% and improved from the first to the last 5-year period (34.8% versus 43.8%, p = 0.04). Five-year survival for stages I and II together was 46.8%, with no significant change in stage distribution between periods. Five-year survival after pneumonectomy was 22.0%, which was significantly lower than for lobectomy (44.6%) and lesser resection (40.7%) (p < 0.005). Unoperated patients had a 5-year survival of 4.8%, as compared to 12.4% for all the NSCLC patients together. Compared with most other published studies, the SRR of NSCLC in Iceland is high. Short-term outcome is good, with a low rate of major complications and an operative mortality of only 1.0%. Five-year survival improved significantly over the study period.


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