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Authors
van der Harst, PimZhang, Weihua
Mateo Leach, Irene
Rendon, Augusto
Verweij, Niek
Sehmi, Joban
Paul, Dirk S
Elling, Ulrich
Allayee, Hooman
Li, Xinzhong
Radhakrishnan, Aparna
Tan, Sian-Tsung
Voss, Katrin
Weichenberger, Christian X
Albers, Cornelis A
Al-Hussani, Abtehale
Asselbergs, Folkert W
Ciullo, Marina
Danjou, Fabrice
Dina, Christian
Esko, Tõnu
Evans, David M
Franke, Lude
Gögele, Martin
Hartiala, Jaana
Hersch, Micha
Holm, Hilma
Hottenga, Jouke-Jan
Kanoni, Stavroula
Kleber, Marcus E
Lagou, Vasiliki
Langenberg, Claudia
Lopez, Lorna M
Lyytikäinen, Leo-Pekka
Melander, Olle
Murgia, Federico
Nolte, Ilja M
O'Reilly, Paul F
Padmanabhan, Sandosh
Parsa, Afshin
Pirastu, Nicola
Porcu, Eleonora
Portas, Laura
Prokopenko, Inga
Ried, Janina S
Shin, So-Youn
Tang, Clara S
Teumer, Alexander
Traglia, Michela
Ulivi, Sheila
Westra, Harm-Jan
Yang, Jian
Zhao, Jing Hua
Anni, Franco
Abdellaoui, Abdel
Attwood, Antony
Balkau, Beverley
Bandinelli, Stefania
Bastardot, François
Benyamin, Beben
Boehm, Bernhard O
Cookson, William O
Das, Debashish
de Bakker, Paul I W
de Boer, Rudolf A
de Geus, Eco J C
de Moor, Marleen H
Dimitriou, Maria
Domingues, Francisco S
Döring, Angela
Engström, Gunnar
Eyjolfsson, Gudmundur Ingi
Ferrucci, Luigi
Fischer, Krista
Galanello, Renzo
Garner, Stephen F
Genser, Bernd
Gibson, Quince D
Girotto, Giorgia
Gudbjartsson, Daniel Fannar
Harris, Sarah E
Hartikainen, Anna-Liisa
Hastie, Claire E
Hedblad, Bo
Illig, Thomas
Jolley, Jennifer
Kähönen, Mika
Kema, Ido P
Kemp, John P
Liang, Liming
Lloyd-Jones, Heather
Loos, Ruth J F
Meacham, Stuart
Medland, Sarah E
Meisinger, Christa
Memari, Yasin
Mihailov, Evelin
Miller, Kathy
Moffatt, Miriam F
Nauck, Matthias
Novatchkova, Maria
Nutile, Teresa
Olafsson, Isleifur
Onundarson, Pall T
Parracciani, Debora
Penninx, Brenda W
Perseu, Lucia
Piga, Antonio
Pistis, Giorgio
Pouta, Anneli
Puc, Ursula
Raitakari, Olli
Ring, Susan M
Robino, Antonietta
Ruggiero, Daniela
Ruokonen, Aimo
Saint-Pierre, Aude
Sala, Cinzia
Salumets, Andres
Sambrook, Jennifer
Schepers, Hein
Schmidt, Carsten Oliver
Silljé, Herman H W
Sladek, Rob
Smit, Johannes H
Starr, John M
Stephens, Jonathan
Sulem, Patrick
Tanaka, Toshiko
Thorsteinsdottir, Unnur
Tragante, Vinicius
van Gilst, Wiek H
van Pelt, L Joost
van Veldhuisen, Dirk J
Völker, Uwe
Whitfield, John B
Willemsen, Gonneke
Winkelmann, Bernhard R
Wirnsberger, Gerald
Algra, Ale
Cucca, Francesco
d'Adamo, Adamo Pio
Danesh, John
Deary, Ian J
Dominiczak, Anna F
Elliott, Paul
Fortina, Paolo
Froguel, Philippe
Gasparini, Paolo
Greinacher, Andreas
Hazen, Stanley L
Jarvelin, Marjo-Riitta
Khaw, Kay Tee
Lehtimäki, Terho
Maerz, Winfried
Martin, Nicholas G
Metspalu, Andres
Mitchell, Braxton D
Montgomery, Grant W
Moore, Carmel
Navis, Gerjan
Pirastu, Mario
Pramstaller, Peter P
Ramirez-Solis, Ramiro
Schadt, Eric
Scott, James
Shuldiner, Alan R
Smith, George Davey
Smith, J Gustav
Snieder, Harold
Sorice, Rossella
Spector, Tim D
Stefansson, Kari
Stumvoll, Michael
Tang, W H Wilson
Toniolo, Daniela
Tönjes, Anke
Visscher, Peter M
Vollenweider, Peter
Wareham, Nicholas J
Wolffenbuttel, Bruce H R
Boomsma, Dorret I
Beckmann, Jacques S
Dedoussis, George V
Deloukas, Panos
Ferreira, Manuel A
Sanna, Serena
Uda, Manuela
Hicks, Andrew A
Penninger, Josef Martin
Gieger, Christian
Kooner, Jaspal S
Ouwehand, Willem H
Soranzo, Nicole
Chambers, John C
Issue Date
2012-12-20
Metadata
Show full item recordCitation
Nature 2012, 492(7429):369-75Abstract
Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://dx.doi.org/10.1038/nature11677http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623669/
http://www.nature.com/nature/journal/v492/n7429/full/nature11677.html
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Archived with thanks to Natureae974a485f413a2113503eed53cd6c53
10.1038/nature11677
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