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dc.contributor.authorVidarsdottir, Halla
dc.contributor.authorMoller, Pall H
dc.contributor.authorJonasson, Jon G
dc.contributor.authorPfannschmidt, Joachim
dc.contributor.authorGudbjartsson, Tomas
dc.date.accessioned2013-09-20T13:58:23Z
dc.date.available2013-09-20T13:58:23Z
dc.date.issued2012-09
dc.date.submitted2013-09-20
dc.identifier.citationThorac Cardiovasc Surg 2012, 60(6):383-9en_GB
dc.identifier.issn1439-1902
dc.identifier.pmid22215491
dc.identifier.doi10.1055/s-0031-1293602
dc.identifier.urihttp://hdl.handle.net/2336/302011
dc.description.abstractThe aim of this retrospective nationwide study was to investigate indications and surgical outcome after pulmonary metastasectomy (PM) in a well-defined cohort of patients and to calculate the proportion of cancer patients who were operated on. Between 1984 and 2008, 81 patients (age 54.8 years, 50.6% men) underwent 100 PMs with curative intent in Iceland. For all patients, information on demographics, number of metastases, type of surgery, and complications were collected. Overall survival was estimated with median follow-up of 45 months. For the three most common malignancies, the proportion of patients who underwent PM was calculated using information from the Icelandic Cancer Registry on all cases diagnosed. Of 100 PMs, there were 62 wedge resections, 34 lobectomies, and 4 pneumonectomies. The most common complication was persistent air leakage (>96 hour; 11.1%), and operative mortality was 1.2%. Of the 12 kinds of primary malignancies operated, three were most common: colorectal carcinoma (CRC, n = 27), sarcoma (n = 21), and renal cell carcinoma (RCC, n = 14). The proportion of patients who underwent PM was 1.0% for CRC, 6.5% for sarcoma, and 1.4% for RCC, and their 5-year overall survival was 45.2, 18.6, and 38.5%, respectively (p = 0.11). Survival for all patients was 30.8%. The surgical outcome and survival of patients who underwent PM in Iceland are comparable to those in the other studies. Although there was no control group and selection bias cannot be eliminated, the survival of PM patients was better than for the nonoperated patients. However, a relatively small proportion of patients with CRC, RCC, and sarcoma underwent metastasectomy.
dc.description.sponsorshipLandspitali Research Funden_GB
dc.language.isoenen
dc.publisherThiemeen_GB
dc.relation.urlhttp://dx.doi.org/10.1055/s-0031-1293602en_GB
dc.rightsArchived with thanks to The Thoracic and cardiovascular surgeonen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshCarcinoma, Renal Cellen_GB
dc.subject.meshChi-Square Distributionen_GB
dc.subject.meshChilden_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshColorectal Neoplasmsen_GB
dc.subject.meshDisease-Free Survivalen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHospital Mortalityen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshKaplan-Meier Estimateen_GB
dc.subject.meshKidney Neoplasmsen_GB
dc.subject.meshLung Neoplasmsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMetastasectomyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPneumonectomyen_GB
dc.subject.meshRegistriesen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Assessmenten_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSarcomaen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.subject.meshYoung Adulten_GB
dc.titleIndications and surgical outcome following pulmonary metastasectomy: a nationwide study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Landspitali University Hospital, Reykjavik, Iceland.en_GB
dc.identifier.journalThoracic and cardiovascular surgeonen_GB
dc.rights.accessClosed - Lokaðen
html.description.abstractThe aim of this retrospective nationwide study was to investigate indications and surgical outcome after pulmonary metastasectomy (PM) in a well-defined cohort of patients and to calculate the proportion of cancer patients who were operated on. Between 1984 and 2008, 81 patients (age 54.8 years, 50.6% men) underwent 100 PMs with curative intent in Iceland. For all patients, information on demographics, number of metastases, type of surgery, and complications were collected. Overall survival was estimated with median follow-up of 45 months. For the three most common malignancies, the proportion of patients who underwent PM was calculated using information from the Icelandic Cancer Registry on all cases diagnosed. Of 100 PMs, there were 62 wedge resections, 34 lobectomies, and 4 pneumonectomies. The most common complication was persistent air leakage (>96 hour; 11.1%), and operative mortality was 1.2%. Of the 12 kinds of primary malignancies operated, three were most common: colorectal carcinoma (CRC, n = 27), sarcoma (n = 21), and renal cell carcinoma (RCC, n = 14). The proportion of patients who underwent PM was 1.0% for CRC, 6.5% for sarcoma, and 1.4% for RCC, and their 5-year overall survival was 45.2, 18.6, and 38.5%, respectively (p = 0.11). Survival for all patients was 30.8%. The surgical outcome and survival of patients who underwent PM in Iceland are comparable to those in the other studies. Although there was no control group and selection bias cannot be eliminated, the survival of PM patients was better than for the nonoperated patients. However, a relatively small proportion of patients with CRC, RCC, and sarcoma underwent metastasectomy.


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