FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies.
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Authors
Zuidmeer-Jongejan, LaurianFernandez-Rivas, Montserrat
Poulsen, Lars K
Neubauer, Angela
Asturias, Juan
Blom, Lars
Boye, Joyce
Bindslev-Jensen, Carsten
Clausen, Michael
Ferrara, Rosa
Garosi, Paula
Huber, Hans
Jensen, Bettina M
Koppelman, Stef
Kowalski, Marek L
Lewandowska-Polak, Anna
Linhart, Birgit
Maillere, Bernard
Mari, Adriano
Martinez, Alberto
Mills, Clare En
Nicoletti, Claudio
Opstelten, Dirk-Jan
Papadopoulos, Nikos G
Portoles, Antonio
Rigby, Neil
Scala, Enrico
Schnoor, Heidi J
Sigursdottir, Sigurveig
Stavroulakis, Georg
Stolz, Frank
Swoboda, Ines
Valenta, Rudolf
van den Hout, Rob
Versteeg, Serge A
Witten, Marianne
van Ree, Ronald
Issue Date
2012-03-09
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Clin Transl Allergy 2012, 2(1):5Abstract
ABSTRACT: The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies, targeting prevalent, persistent and severe allergy to fish and peach. Classical allergen-specific immunotherapy (SIT), using subcutaneous injections with aqueous food extracts may be effective but has proven to be accompanied by too many anaphylactic side-effects. FAST aims to develop a safe alternative by replacing food extracts with hypoallergenic recombinant major allergens as the active ingredients of SIT. Both severe fish and peach allergy are caused by a single major allergen, parvalbumin (Cyp c 1) and lipid transfer protein (Pru p 3), respectively. Two approaches are being evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypoallergens will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), SCIT with alum-absorbed hypoallergens will be evaluated in phase I/IIa and IIb randomized double-blind placebo-controlled (DBPC) clinical trials, with the DBPC food challenge as primary read-out. To understand the underlying immune mechanisms in depth serological and cellular immune analyses will be performed, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST aims at improving the quality of life of food allergic patients by providing a safe and effective treatment that will significantly lower their threshold for fish or peach intake, thereby decreasing their anxiety and dependence on rescue medication.Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://dx.doi.org/10.1186/2045-7022-2-5http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386014/
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Archived with thanks to Clinical and translational allergyae974a485f413a2113503eed53cd6c53
10.1186/2045-7022-2-5
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