• Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland.

      Ingimarsson, Oddur; MacCabe, James H; Haraldsson, Magnús; Jónsdóttir, Halldóra; Sigurdsson, Engilbert; 1 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland. 2 Landspitali University Hospital, Mental Health Services, Hringbraut, 101, Reykjavik, Iceland. 3 Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College, London, UK. 4National Psychosis Unit, Bethlem Royal Hospital, South London and Maudsley NHS Foundation Trust, London, UK. 5 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland. 6 Landspitali University Hospital, Mental Health Services, Hringbraut, 101, Reykjavik, Iceland. (BioMed Central, 2016-12-12)
      Data on the haematological outcomes of patients who continue clozapine treatment following neutropenia are very rare as even mild neutropenia results in mandatory discontinuation of clozapine in most countries. However, in Iceland where clozapine monitoring is less stringent allows an observational study to be done on the risk of agranulocytosis and neutropenia during treatment with clozapine compared with other antipsychotics among patients with schizophrenia.