• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
Search 
  •   Home
  • ec_fundedresources to openaire
  • Search
  •   Home
  • ec_fundedresources to openaire
  • Search
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CommunityAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Filter by Category

SubjectsBAB12 (1)Blóðgjöf (1)NAF12 (1)View MoreJournal
Blood (1)
Authors[ 1 ] European Acad Bozen Bolzano, Ctr Biomed, Via Galvani 31, I-39100 Bolzano, Italy [ 2 ] Univ Colorado Denver, Sch Med, Dept Biochem & Mol Genet, Aurora, CO USA [ 3 ] Univ Iceland, Ctr Syst Biol, Reykjavik, Iceland [ 4 ] Landspitali Univ Hosp, Blood Bank, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 5 ] Reykjavik Unvers, Sch Sci & Engn, Reykjavik, Iceland [ 6 ] Sinopia Biosci, San Diego, CA USA (1)
Bordbar, Aarash (1)
D'Alessandro, Angelo (1)
Gudmundsson, Sveinn (1)Hansen, Kirk C (1)View MoreTypes
article (1)

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics
 

Search

Show Advanced FiltersHide Advanced Filters

Filters

Now showing items 1-1 of 1

  • List view
  • Grid view
  • Sort Options:
  • Relevance
  • Title Asc
  • Title Desc
  • Issue Date Asc
  • Issue Date Desc
  • Results Per Page:
  • 5
  • 10
  • 20
  • 40
  • 60
  • 80
  • 100

  • 1CSV
  • 1RefMan
  • 1EndNote
  • 1BibTex
  • Selective Export
  • Select All
  • Help
Thumbnail

Biomarkers defining the metabolic age of red blood cells during cold storage.

Paglia, Giuseppe; D'Alessandro, Angelo; Rolfsson, Óttar; Sigurjónsson, Ólafur E; Bordbar, Aarash; Palsson, Sirus; Nemkov, Travis; Hansen, Kirk C; Gudmundsson, Sveinn; Palsson, Bernhard O (Amer Soc Hematology, 2016-09-29)
Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated conditions in saline adenine glucose mannitol (SAGM) additives have revealed the presence of 3 distinct metabolic phases, occurring on days 0-10, 10-18, and after day 18 of storage. Here we used receiving operating characteristics curve analysis to identify biomarkers that can differentiate between the 3 metabolic states. We first recruited 24 donors and analyzed 308 samples coming from RBC concentrates stored in SAGM and additive solution 3. We found that 8 extracellular compounds (lactic acid, nicotinamide, 5-oxoproline, xanthine, hypoxanthine, glucose, malic acid, and adenine) form the basis for an accurate classification/regression model and are able to differentiate among the metabolic phases. This model was then validated by analyzing an additional 49 samples obtained by preparing 7 new RBC concentrates in SAGM. Despite the technical variability associated with RBC processing strategies, verification of these markers was independently confirmed in 2 separate laboratories with different analytical setups and different sample sets. The 8 compounds proposed here highly correlate with the metabolic age of packed RBCs, and can be prospectively validated as biomarkers of the RBC metabolic lesion.
DSpace software (copyright © 2002 - 2019)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.