• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
Search 
  •   Home
  • ec_fundedresources to openaire
  • Search
  •   Home
  • ec_fundedresources to openaire
  • Search
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CommunityAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Filter by Category

Subjects
Aldraðir (1)
View MoreJournalAnalytical chemistry (1)Authors
[ 1 ] Ist Zooprofilatt Sperimentale Puglia & Basilicata, Foggia, Italy [ 2 ] Univ Iceland, Ctr Syst Biol, Reykjavik, Iceland [ 3 ] Protea Biosci Grp Inc, Morgantown, WV 26505 USA [ 4 ] Waters Corp, Milford, MA 01757 USA [ 5 ] Duke Prote Core Facil, Durham, NC 27708 USA [ 6 ] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06268 USA [ 7 ] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London, England [ 8 ] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA (1)
Angel, Peggi (1)
Astarita, Giuseppe (1)
Geromanos, Scott (1)Grant, David F (1)View MoreTypes
article (1)

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics
 

Search

Show Advanced FiltersHide Advanced Filters

Filters

Now showing items 1-1 of 1

  • List view
  • Grid view
  • Sort Options:
  • Relevance
  • Title Asc
  • Title Desc
  • Issue Date Asc
  • Issue Date Desc
  • Results Per Page:
  • 5
  • 10
  • 20
  • 40
  • 60
  • 80
  • 100

  • 1CSV
  • 1RefMan
  • 1EndNote
  • 1BibTex
  • Selective Export
  • Select All
  • Help
Thumbnail

Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification.

Paglia, Giuseppe; Angel, Peggi; Williams, Jonathan P; Richardson, Keith; Olivos, Hernando J; Thompson, J Will; Menikarachchi, Lochana; Lai, Steven; Walsh, Callee; Moseley, Arthur; et al. (Amer Chemical Soc, 2015-01-20)
Despite recent advances in analytical and computational chemistry, lipid identification remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate measure of the molecules' rotationally averaged collision cross-section (CCS) in the gas phase and is thus related to ionic shape. Here, we investigate the use of CCS as a highly specific molecular descriptor for identifying lipids in biological samples. Using traveling wave ion mobility mass spectrometry (MS), we measured the CCS values of over 200 lipids within multiple chemical classes. CCS values derived from ion mobility were not affected by instrument settings or chromatographic conditions, and they were highly reproducible on instruments located in independent laboratories (interlaboratory RSD < 3% for 98% of molecules). CCS values were used as additional molecular descriptors to identify brain lipids using a variety of traditional lipidomic approaches. The addition of CCS improved the reproducibility of analysis in a liquid chromatography-MS workflow and maximized the separation of isobaric species and the signal-to-noise ratio in direct-MS analyses (e.g., "shotgun" lipidomics and MS imaging). These results indicate that adding CCS to databases and lipidomics workflows increases the specificity and selectivity of analysis, thus improving the confidence in lipid identification compared to traditional analytical approaches. The CCS/accurate-mass database described here is made publicly available.
DSpace software (copyright © 2002 - 2019)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.